4-Chloropyridine-2-carboxylic acid
- Product Name
- 4-Chloropyridine-2-carboxylic acid
- CAS No.
- 5470-22-4
- Chemical Name
- 4-Chloropyridine-2-carboxylic acid
- Synonyms
- 4-CHLOROPICOLINIC ACID;4-chloropicolinic;Chloropicolinicacid;IFLAB-BB F1926-0017;4-ChloropicolinicAci;Sorafenib Impurity 03;4-chloro-2-picolinic acid;4-CHLOROPICOLINIC ACID 99%;4-Chloropicolinic acid ,98%;4-Chloropicolinic acid, 97.5%
- CBNumber
- CB7353077
- Molecular Formula
- C6H4ClNO2
- Formula Weight
- 157.55
- MOL File
- 5470-22-4.mol
4-Chloropyridine-2-carboxylic acid Property
- Melting point:
- 181°C
- Boiling point:
- 308.0±22.0 °C(Predicted)
- Density
- 1.470±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.27±0.10(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- InChI
- InChI=1S/C6H4ClNO2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H,9,10)
- InChIKey
- NNMYRMGMVLMQAY-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=CC(Cl)=C1
- CAS DataBase Reference
- 5470-22-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Harmful/Irritant/Keep Cold
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS000043
- Product name
- 4-Chloro-2-pyridinecarboxylic acid
- Purity
- AldrichCPR
- Packaging
- 100MG
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- ADE000290
- Product name
- 4-Chloro-pyridine-2-carboxylic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- C1360
- Product name
- 4-Chloro-2-pyridinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- C1360
- Product name
- 4-Chloro-2-pyridinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $225
- Updated
- 2025/07/31
- Product number
- C370955
- Product name
- 4-ChloropicolinicAcid
- Packaging
- 5g
- Price
- $195
- Updated
- 2021/12/16
4-Chloropyridine-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
4-Chloropicolinic Acid is a reactant used in the synthesis of VU0431316, a negative allosteric modulator of mGlu5.
Synthesis
98-98-6
5470-22-4
General procedure for the synthesis of 4-chloropyridine-2-carboxylic acid from 2-pyridinecarboxylic acid: a suspension of 2-pyridinecarboxylic acid (0.79 g, 6.35 mmol) and sodium bromide (1.30 g, 12.7 mmol) in 10 mL of thionyl chloride was heated for 20 hr under mild reflux conditions. During the reaction, the initial dark green color of the mixture gradually changed to a deep red color. Upon completion of the reaction, the excess thionyl chloride was removed by rotary evaporation, and the resulting orange residue was dissolved in about 15 mL of dichloromethane and filtered through diatomaceous earth to remove insoluble impurities. The orange filtrate was cooled to -2°C and 20 mL of double-distilled water was slowly added under vigorous stirring while maintaining the reaction temperature between -2 and 2°C. At this point, the color of the solution changed to light orange and a white precipitate was produced. Subsequently, the mixture was continued to be stirred at room temperature for 20 hours. Afterwards, dichloromethane and water were removed by rotary evaporation. Finally, the solid product was recrystallized from a minimal amount of ethanol to give 0.28 g (28% yield) of 4-chloropyridine-2-carboxylic acid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ= 8.72 (1H, d, J = 4.9 Hz), 8.09 (1H, d, J = 1.6 Hz), 7.84 (1H, dd, J = 4.9, 1.6 Hz).
References
[1] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 48-49
[2] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 48-49
[3] Synthetic Communications, 1996, vol. 26, # 10, p. 2017 - 2025
[4] Patent: US2006/160803, 2006, A1. Location in patent: Page/Page column 136
[5] Patent: EP1650194, 2006, A1. Location in patent: Page/Page column 37
4-Chloropyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloropyridine-2-carboxylic acid Suppliers
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- Country
- The Netherlands
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View Lastest Price from 4-Chloropyridine-2-carboxylic acid manufacturers
- Product
- 4-Chloropyridine-2-carboxylic acid 5470-22-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-22
- Product
- 4-Chloropyridine-2-carboxylic acid 5470-22-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 4-Chloropyridine-2-carboxylic acid 5470-22-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-21