2-Methoxy-5-sulfamoylbenzoic acid
- Product Name
- 2-Methoxy-5-sulfamoylbenzoic acid
- CAS No.
- 22117-85-7
- Chemical Name
- 2-Methoxy-5-sulfamoylbenzoic acid
- Synonyms
- Sulpride Impurity D;Sulpiride IMpurity D;Sulpiride EP Impurity D;Sulpiride Impurity D(EP);5-SulfaMoyl-o-anisic Acid;5-sulphamoyl-o-anisic acid;Levosulpiride - EP Impurity D;2-Methoxy-5-sulfamoylbenzoicaci;2-METHOXY-5-SULFONYLBENZOIC ACID;2-METHOXY-5-SULFAMOYLBENZOIC ACID
- CBNumber
- CB7354418
- Molecular Formula
- C8H9NO5S
- Formula Weight
- 231.23
- MOL File
- 22117-85-7.mol
2-Methoxy-5-sulfamoylbenzoic acid Property
- Melting point:
- 220 °C
- Boiling point:
- 482.5±55.0 °C(Predicted)
- Density
- 1.492±0.06 g/cm3(Predicted)
- storage temp.
- Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.56±0.10(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 22117-85-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B23698
- Product name
- 2-Methoxy-5-sulfamoylbenzoic acid, 97%
- Packaging
- 10g
- Price
- $45.65
- Updated
- 2024/03/01
- Product number
- B23698
- Product name
- 2-Methoxy-5-sulfamoylbenzoic acid, 97%
- Packaging
- 50g
- Price
- $129.65
- Updated
- 2024/03/01
- Product number
- B23698
- Product name
- 2-Methoxy-5-sulfamoylbenzoic acid, 97%
- Packaging
- 250g
- Price
- $459
- Updated
- 2021/12/16
- Product number
- M326640
- Product name
- 2-Methoxy-5-sulfamoylbenzoicAcid
- Packaging
- 10g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- OR3567
- Product name
- 2-Methoxy-5-sulphamoylbenzoicacid
- Packaging
- 250g
- Price
- $215
- Updated
- 2021/12/16
2-Methoxy-5-sulfamoylbenzoic acid Chemical Properties,Usage,Production
Uses
2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).
Preparation
Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.
2-Methoxy-5-sulfamoylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methoxy-5-sulfamoylbenzoic acid manufacturers
- Product
- 2-Methoxy-5-sulfamoylbenzoic acid 22117-85-7
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21