2-Methoxy-5-sulfamoylbenzoic acid

Product Name: 2-Methoxy-5-sulfamoylbenzoic acid
CAS No.: 22117-85-7
Chemical Name: 2-Methoxy-5-sulfamoylbenzoic acid
Synonyms: Sulpride Impurity D;Sulpiride IMpurity D;Sulpiride EP Impurity D;Sulpiride Impurity D(EP);5-SulfaMoyl-o-anisic Acid;5-sulphamoyl-o-anisic acid;Levosulpiride - EP Impurity D;2-Methoxy-5-sulfamoylbenzoicaci;2-METHOXY-5-SULFONYLBENZOIC ACID;2-METHOXY-5-SULFAMOYLBENZOIC ACID
CBNumber: CB7354418
Molecular Formula: C8H9NO5S
Formula Weight: 231.23
MOL File: 22117-85-7.mol

More

Less

2-Methoxy-5-sulfamoylbenzoic acid Property

Melting point:: 220 °C
Boiling point:: 482.5±55.0 °C(Predicted)
Density: 1.492±0.06 g/cm3(Predicted)
storage temp.: Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.56±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C8H9NO5S/c1-14-7-3-2-5(15(9,12)13)4-6(7)8(10)11/h2-4H,1H3,(H,10,11)(H2,9,12,13)
InChIKey: SQAILWDRVDGLGY-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(S(N)(=O)=O)=CC=C1OC
CAS DataBase Reference: 22117-85-7(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HS Code: 2922500090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: M2771
Product name: 2-Methoxy-5-sulfamoylbenzoic Acid
Packaging: 5G
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: M2771
Product name: 2-Methoxy-5-sulfamoylbenzoic Acid
Packaging: 25G
Price: $160
Updated: 2025/07/31

TRC

Product number: M326640
Product name: 2-Methoxy-5-sulfamoylbenzoicAcid
Packaging: 10g
Price: $180
Updated: 2021/12/16

Apolloscientific

Product number: OR3567
Product name: 2-Methoxy-5-sulphamoylbenzoicacid
Packaging: 250g
Price: $215
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6669-1-X0
Product name: 2-Methoxy-5-sulfamoylbenzoic acid
Packaging: 250g
Price: $237
Updated: 2021/12/16

More

Less

2-Methoxy-5-sulfamoylbenzoic acid Chemical Properties,Usage,Production

Uses

2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).

Preparation

Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.

2-Methoxy-5-sulfamoylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Methoxy-5-sulfamoylbenzoic acid Suppliers

Canada 1 China 126 Europe 3 France 1 Germany 2 India 14 Italy 1 Japan 2 Slovakia 1 South Korea 1 Ukraine 2 United Kingdom 14 United States 28 Global 196

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Cato Research Chemicals Inc.

Tel: +86-020-81960175-877 4000-868-328
Email: tianwen.zhan@cato-chem.com
Country: United States
ProdList: 10404
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19961
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Ivy Fine Chemicals

Tel: --
Fax: --
Email: sales@ivychem.com
Country: United States
ProdList: 6493
Advantage: 58

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Aozeal Certified Standards (AOCS), Inc.

Tel: --
Fax: --
Email: info@aozeal.com
Country: United States
ProdList: 504
Advantage: 58

Alichem Inc.

Tel: --
Fax: --
Email: sales@alichem.com
Country: United States
ProdList: 6167
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

CacheSyn Inc.

Tel: --
Fax: --
Email: info@cachesyn.com
Country: United States
ProdList: 695
Advantage: 50

NetQem

Tel: --
Fax: --
Email: sales@netqem.us
Country: United States
ProdList: 1641
Advantage: 38

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

Kingchem Inc.

Tel: --
Fax: --
Email: s.wang@kingchem.com
Country: United States
ProdList: 757
Advantage: 60

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

Wilshire Chemical Company Inc.

Tel: --
Fax: --
Email: WilshrChem@AOL.COM
Country: United States
ProdList: 3498
Advantage: 58

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

More

Less

View Lastest Price from 2-Methoxy-5-sulfamoylbenzoic acid manufacturers

Career Henan Chemical Co

Product: 2-Methoxy-5-sulfamoylbenzoic acid 22117-85-7
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-21

22117-85-7, 2-Methoxy-5-sulfamoylbenzoic acidRelated Search:

2-Methoxybenzoic acid 4-Methoxybenzoic acid Sulfanilamide p-Anisidine p-Toluenesulfonamide Methoxyacetic acid (Trifluoromethoxy)benzene Anisole EPA p-Anisaldehyde Ascoric Acid Ethyl 2-methoxy-5-sulfamoylbenzoate 2,3-Dimethoxy-5-sulphamoylbenzoic acid 2-METHOXY-5-SULFAMOYLBENZOIC ACID METHYL ESTER 4-Chloro-2-Methoxy-5-Sulfamoylbenzoic Acid Sulpiride Benzonitrile CHEMBRDG-BB 6629596

2-METHOXY-5-SULFAMOYLBENZOIC ACID

2-METHOXY-5-SULFONYLBENZOIC ACID

2-METHOXY-5-SULPHAMOYLBENZOIC ACID

3-CARBOXY-4-METHOXY-BENZENE SULFONAMIDE

2-Methoxy-5-Sufamoyl Benzoic Acid

5-Aminosulfonyl-2-Methoxybenzoic Acid

5-sulphamoyl-o-anisic acid

5-(Aminosulphonyl)-2-methoxybenzoic acid

2-METHOXY-5-SULFONAMIDOBENZOIC ACID

3-Carboxy-4-methoxybenzenesulphonamide

2-Methoxy-5-sulfaMidobenzoic Acid

5-SulfaMoyl-o-anisic Acid

2-METHOXY-5-SULFAMOYLBENZOIC ACIDSULPIRIDE

Sulpiride IMpurity D

3-Carboxy-4-methoxybenzenesulphonamide, 5-(Aminosulphonyl)-o-anisic acid

6-methoxy-3-sulfonyl-1-cyclohexa-1,5-dienecarboxylic acid

Sulpiride Impurity 4（Sulpiride EP Impurity D）

Benzoic acid,5-(aMinosulfonyl)-2-Methoxy-

carbazole2-Methoxy-5-sulfamoylbenzoic acid

Sulpiride Impurity D(EP)

Sulpiride EP Impurity D

Levosulpiride - EP Impurity D

5-[(Aminoperoxy)thio]-2-methoxybenzoic Acid

2-Methoxy-5-sulfamoylbenzoicaci

Sulpride Impurity D

2-Methoxy-5-sulfamoylbenzoic acid, 10 mM in DMSO

2-methoxy-5-sulfonic acid benzamide

2-Methoxy-5-suifamoylbenzoic acid

22117-85-7

C8H8NO5S

Organic acids

Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds