3-Bromo-5-methylpyridine

Product Name: 3-Bromo-5-methylpyridine
CAS No.: 3430-16-8
Chemical Name: 3-Bromo-5-methylpyridine
Synonyms: 3-brmo-5-me;3-Bromo-5-methyL;5-BROMO-3-PICOLINE;3-BROMO-5-METHYLPY...;3-brmo-5-methylpyridine;3-methy-5-bromopyridine;3-BROMO-5-METHYLPYRIDINE;3-Methyl-5-Bromopyridine;Pyridine, 3-bromo-5-methyl-;3-Bromo-5-methylpyridine >
CBNumber: CB7416792
Molecular Formula: C6H6BrN
Formula Weight: 172.02
MOL File: 3430-16-8.mol

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3-Bromo-5-methylpyridine Property

Melting point:: 16.5-16.7 °C
Boiling point:: 110°C/25mmHg(lit.)
Density: 1.4869 g/mL at 25 °C
refractive index: 1.5618
Flash point:: 91 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.16±0.20(Predicted)
form: powder to lump to clear liquid
color: White or Colorless to Almost white or Almost colorless
CAS DataBase Reference: 3430-16-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-22
Safety Statements: 26-36/37/39-39
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 681245
Product name: 3-Bromo-5-methylpyridine
Purity: 97%
Packaging: 250mg
Price: $128
Updated: 2023/06/20

TCI Chemical

Product number: B3724
Product name: 3-Bromo-5-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: B3724
Product name: 3-Bromo-5-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $166
Updated: 2025/07/31

TRC

Product number: B685580
Product name: 5-Bromo-3-picoline
Packaging: 25g
Price: $1230
Updated: 2021/12/16

AK Scientific

Product number: J93718
Product name: 3-Bromo-5-methylpyridine
Packaging: 1g
Price: $10
Updated: 2021/12/16

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3-Bromo-5-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

5-Bromo-3-picoline is an intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity

Synthesis

625-92-3

823-96-1

3430-16-8

The general procedure for the synthesis of 3-bromo-5-methylpyridine from 3,5-dibromopyridine and trimethylcyclotriboroxane was as follows: under nitrogen protection, cesium carbonate (1.38 g, 4.22 mmol), trimethylcyclotriboroxane (0.2 mL, 1.47 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.488 g, 0.42 mmol ). Subsequently, a solution of 3,5-dibromopyridine (1.0 g, 4.22 mmol) dissolved in a 9:1 solvent mixture of dioxane and water (10 mL) was added. The reaction mixture was stirred at 110 °C for 16 hours. Upon completion of the reaction, trimethylcyclotriboroxane (0.2 mL, 1.47 mmol) was added again and the reaction temperature was lowered to 100 °C and the reaction continued to be stirred for 16 hours. At the end of the reaction, the reaction mixture was cooled to room temperature, filtered through diatomaceous earth and the filter cake was washed with ethyl acetate. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography with the eluent being a 80:20 solvent mixture of hexane and ethyl acetate, resulting in 3-bromo-5-methylpyridine as a colorless oil (0.654 g, 90% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 2.34 (s, 3H), 7.66 (s, 1H), 8.36 (s, 1H), 8.49 (s, 1H).GC-MS (EI) analysis showed: m/z = 171.0, 173.0 [M].

References

[1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 25

3-Bromo-5-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Bromo-5-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Bromo-5-methylpyridine 3430-16-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-30

Henan Fengda Chemical Co., Ltd

Product: 3-Bromo-5-methylpyridine 3430-16-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 3-Bromo-5-methylpyridine 3430-16-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-26

3430-16-8, 3-Bromo-5-methylpyridineRelated Search:

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3430-16-8

Heterocycle-Pyridine series

Pyridines

Building Blocks

Halides

Boronic Acid

C5Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines