ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-aminopyrimidine

2,4-Dichloro-5-aminopyrimidine

Product Name
2,4-Dichloro-5-aminopyrimidine
CAS No.
5177-27-5
Chemical Name
2,4-Dichloro-5-aminopyrimidine
Synonyms
5-Amino-2,4-dichL;2,4-dichlorpyrimidin-5-amin;4-Dichloro-5-aminopyrimidine;2,4-Dichloro-5-pyrimidinamine;2,4-DICHLOROPYRIMIDIN-5-AMINE;5-AMINO-2,4-DICHLOROPYRIMIDINE;2,4-DICHLORO-5-AMINOPYRIMIDINE;2,4-Dichloropyrimidine-5-amine;5-Pyrimidinamine, 2,4-dichloro-;2,4-DICHLORO-PYRIMIDIN-5-YLAMINE
CBNumber
CB7442834
Molecular Formula
C4H3Cl2N3
Formula Weight
163.99
MOL File
5177-27-5.mol
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2,4-Dichloro-5-aminopyrimidine Property

Melting point:
108-112?C
Boiling point:
290.7±20.0 °C(Predicted)
Density 
1.606±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO, Methanol
form 
Solid
pka
-1.55±0.29(Predicted)
color 
Brown
InChI
InChI=1S/C4H3Cl2N3/c5-3-2(7)1-8-4(6)9-3/h1H,7H2
InChIKey
RINHVELYMZLXIW-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(N)C(Cl)=N1
CAS DataBase Reference
5177-27-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39-24/25
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
731919
Product name
5-Amino-2,4-dichloropyrimidine
Purity
97%
Packaging
1g
Price
$31.3
Updated
2023/06/20
TRC
Product number
A604720
Product name
5-Amino-2,4-dichloropyrimidine
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
A604720
Product name
5-Amino-2,4-dichloropyrimidine
Packaging
10g
Price
$160
Updated
2021/12/16
Matrix Scientific
Product number
073493
Product name
5-Amino-2,4-dichloropyrimidine
Purity
95+%
Packaging
25g
Price
$178
Updated
2021/12/16
AK Scientific
Product number
B868
Product name
2,4-Dichloropyrimidin-5-amine
Packaging
5g
Price
$109
Updated
2021/12/16
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2,4-Dichloro-5-aminopyrimidine Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

A pyrimidinamine derivative as Plk1 inhibitors

Synthesis

49845-33-2

5177-27-5

General procedure for the synthesis of 5-amino-2,4-dichloropyrimidine from 2,4-dichloro-5-nitropyrimidine: 2,4-dichloro-5-nitropyrimidine (1.0 eq.) and iron powder (6.0 eq.) were formulated in acetic acid to form a non-homogeneous reaction system at a concentration of 0.4 M, and the reaction was carried out for 14 hours at room temperature with vigorous stirring. Upon completion of the reaction, the reaction mixture was thermally filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was washed with methanol (MeOH) and the volatile solvent was subsequently evaporated under reduced pressure. The resulting residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated sodium carbonate (Na2CO3) solution and saturated sodium chloride (NaCl) solution to remove acidic impurities and salts. The organic phase was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product 5-amino-2,4-dichloropyrimidine in 80% yield. The product was analyzed by liquid chromatography-mass spectrometry (LCMS), showing a molecular ion peak (MH+) of 157.0 and a retention time (Rt) of 1.85 min.

References

[1] Patent: US2011/195980, 2011, A1. Location in patent: Page/Page column 17
[2] Patent: WO2011/106168, 2011, A1. Location in patent: Page/Page column 83; 84; 101; 102
[3] Journal of the Chemical Society, 1951, p. 1565,1568
[4] Journal of the Chemical Society, 1953, p. 1646
[5] Chemical and Pharmaceutical Bulletin, 1958, vol. 6, p. 352,354

2,4-Dichloro-5-aminopyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloro-5-aminopyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2,4-Dichloro-5-aminopyrimidine 5177-27-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Shaanxi Dideu Medichem Co. Ltd
Product
5-amino-2,4-dichloropyrimidine 5177-27-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,4-Dichloro-5-aminopyrimidine 5177-27-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

5177-27-5, 2,4-Dichloro-5-aminopyrimidineRelated Search:

2',4'-Dichloroacetophenone 1,2-Dichloro-4-(chloromethyl)benzene Dichloroethane Glycine 6-Aminocaproic acid 3-Aminophenol ALTRENOGEST EC 2.6.1.2 2,4-Dichloropyrimidine Acetaminophen 5-Amino-2-chloropyrimidine Tris(hydroxymethyl)aminomethane 2,4-Dichloro-6-methyl-5-nitropyrimidine 2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE 2,4,6-TRICHLORO-5-NITROPYRIMIDINE 2,6-Dichloro-4-aminopyrimidine 2,4-Dichloro-5-nitropyrimidine 2,4-Dichloro-5-(1H-pyrazol-1-yl)pyrimidine

  • 2,4-DICHLORO-PYRIMIDIN-5-YLAMINE
  • 2,4-DICHLORO-5-AMINOPYRIMIDINE
  • 5-AMINO-2,4-DICHLOROPYRIMIDINE
  • 2,4-DICHLOROPYRIMIDIN-5-AMINE
  • 5-Amino-2,4-dichloropyrimidine ,98%
  • 2,4-Dichloro-5-pyrimidinamine
  • 5-AMino-2,4-dichloropyriMidine 97%
  • 2,4-di chloro-5-aMinoMpyriMidine
  • 5-Pyrimidinamine, 2,4-dichloro-
  • 5-Amino-2,4-dichL
  • 5-Amino-2,4-dichloropyrimidine,97%
  • 2,4-Dichloropyrimidine-5-amine
  • 2,4-dichlorpyrimidin-5-amin
  • 4-Dichloro-5-aminopyrimidine
  • 2,4-Dichloropyrimidin-5-amine 97%
  • 5177-27-5
  • Heterocycle-Pyrimidine series
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • pharmacetical
  • Amines