5-Amino-2-chloropyrimidine

Product Name: 5-Amino-2-chloropyrimidine
CAS No.: 56621-90-0
Chemical Name: 5-Amino-2-chloropyrimidine
Synonyms: 2-CHLOROPYRIMIDIN-5-AMINE;2-Chloro-5-pyrimidinamine;5-amine-2-Chloropyrimidine;5-AMINO-2-CHLOROPYRIMIDINE;5-PYRIMIDINAMINE, 2-CHLORO-;2-Chloro-pyrimidin-5-ylamine;5-AMINO-2-CHLOROPYRIMIDINE,98%;5-AMino-2-chloropyriMidine 97%;5-Amino-2-chloropyrimidine ,97%;5-Pyrimidinamine, 2-chloro- (9CI)
CBNumber: CB4461216
Molecular Formula: C4H4ClN3
Formula Weight: 129.55
MOL File: 56621-90-0.mol

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5-Amino-2-chloropyrimidine Property

Melting point:: 198-199℃
Boiling point:: 338.8±15.0 °C(Predicted)
Density: 1.437±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -0.08±0.10(Predicted)
form: Crystalline Powder or Solid
color: Yellow to brown
InChI: InChI=1S/C4H4ClN3/c5-4-7-1-3(6)2-8-4/h1-2H,6H2
InChIKey: DZBKIOJXVOECRA-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(N)C=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22-36-36/37/38
Safety Statements: 26-36/37/39-22
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: A576623
Product name: 5-Amino-2-chloropyrimidine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: W7026
Product name: 5-Amino-2-chloropyrimidine
Packaging: 250mg
Price: $19
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C11247
Product name: 2-Chloro-5-aminopyrimidine
Purity: 95%
Packaging: 1g
Price: $25
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: CAPOC11247
Product name: 2-Chloro-5-aminopyrimidine
Purity: 95%
Packaging: 1g
Price: $25
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-5-Q0
Product name: 5-Amino-2-chloropyrimidine
Purity: 95%
Packaging: 1g
Price: $29
Updated: 2021/12/16

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5-Amino-2-chloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

5-Amino-2-chloropyrimidine is an aminopyrimidine derivative, a fibroblast growth factor receptor 4 inhibitor with anticancer activity.

Synthesis

10320-42-0

56621-90-0

Example 7 Synthesis of 5-amino-2-chloropyrimidine (Compound 40): according to the reaction scheme, 140 g (0.88 mol) of 2-chloro-5-nitropyrimidine (39) was dissolved in 700 mL of ethanol (EtOH) with the addition of 1400 mL of acetic acid, 700 mL of water and 197 g of iron powder (70 μm sieve, <212 μm). The reaction mixture was heated at 70 °C overnight and subsequently cooled to room temperature. After completion of the reaction, filtration was performed. EtOH was removed from the filtrate under vacuum and the pH was adjusted to 8 with 12N NaOH, followed by continuous liquid-liquid extraction with ethyl acetate (EtOAc) overnight to extract the product. The resulting filter cake was washed with EtOAc and the combined EtOAc layers were washed sequentially with water and brine, dried with magnesium sulfate and filtered. The solvent was removed under vacuum and the product was recrystallized with EtOH to give 97.2 g (85% yield) of the final light brown solid product 39.1H NMR (DMSO-d6) δ 8.94 (s, 2H), 5.77 (brs, 2H).

References

[1] Tetrahedron, 2014, vol. 70, # 35, p. 5730 - 5738
[2] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0267
[3] Patent: US2014/235858, 2014, A1. Location in patent: Paragraph 0093
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 22, p. 8796 - 8805
[5] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 56

5-Amino-2-chloropyrimidine Preparation Products And Raw materials

Raw materials

Heptane NITROMALONALDEHYDE Nitrogen Ethanol Piperidine 5-NITRO-PYRIMIDIN-2-OL Phosphorus oxitrichloride Urea Carbon tetrachloride Sodium nitrite Guanidine hydrochloride Benzene Ethyl acetate Methanol Sodium hydroxide Iron PETROLEUM ETHER Mucobromic acid

Preparation Products

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5-Amino-2-chloropyrimidine Suppliers

China 200 Europe 1 Germany 1 India 3 United Kingdom 8 United States 22 Global 235

Hunan Caiya Biological Technology Co., Ltd

Tel: 15580017485
Email: 2036676503@qq.com
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Shandong Zhonghan Pharmaceutical Co.,Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Energy Chemical

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Capot Chemical Co., Ltd

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Changzhou Huanling Chemical Co., Ltd.

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Shangchem Co., Ltd.

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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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View Lastest Price from 5-Amino-2-chloropyrimidine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Amino-2-chloropyrimidine 56621-90-0
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Shaanxi Dideu Medichem Co. Ltd

Product: 2-chloropyrimidin-5-amine 56621-90-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Career Henan Chemical Co

Product: 5-Amino-2-chloropyrimidine 56621-90-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-01

56621-90-0, 5-Amino-2-chloropyrimidineRelated Search:

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2-CHLOROPYRIMIDIN-5-AMINE

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5-AMINO-2-CHLOROPYRIMIDINE

2-Chloro-pyrimidin-5-ylamine

5-Pyrimidinamine, 2-chloro- (9CI)

5-AMINO-2-CHLOROPYRIMIDINE,98%

5-Amino-2-chloropyrimidine ,97%

5-amine-2-Chloropyrimidine

5-AMino-2-chloropyriMidine 97%

2-Chloropyrimidin-5-amine, 5-Amino-2-chloro-1,3-diazine

2-Chloro-5-pyrimidinamine

56621-90-0

Heterocycle-Pyrimidine series

Building Blocks

Amines

Pyrazines, Pyrimidines & Pyridazines

PYRIMIDINE