2,4-Dichloro-5-aminopyrimidine

Product Name: 2,4-Dichloro-5-aminopyrimidine
CAS No.: 5177-27-5
Chemical Name: 2,4-Dichloro-5-aminopyrimidine
Synonyms: 5-Amino-2,4-dichL;2,4-dichlorpyrimidin-5-amin;4-Dichloro-5-aminopyrimidine;2,4-Dichloro-5-pyrimidinamine;2,4-DICHLOROPYRIMIDIN-5-AMINE;5-AMINO-2,4-DICHLOROPYRIMIDINE;2,4-DICHLORO-5-AMINOPYRIMIDINE;2,4-Dichloropyrimidine-5-amine;5-Pyrimidinamine, 2,4-dichloro-;2,4-DICHLORO-PYRIMIDIN-5-YLAMINE
CBNumber: CB7442834
Molecular Formula: C4H3Cl2N3
Formula Weight: 163.99
MOL File: 5177-27-5.mol

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2,4-Dichloro-5-aminopyrimidine Property

Melting point:: 108-112?C
Boiling point:: 290.7±20.0 °C(Predicted)
Density: 1.606±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO, Methanol
form: Solid
pka: -1.55±0.29(Predicted)
color: Brown
InChI: InChI=1S/C4H3Cl2N3/c5-3-2(7)1-8-4(6)9-3/h1H,7H2
InChIKey: RINHVELYMZLXIW-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(N)C(Cl)=N1
CAS DataBase Reference: 5177-27-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39-24/25
RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 731919
Product name: 5-Amino-2,4-dichloropyrimidine
Purity: 97%
Packaging: 1g
Price: $31.3
Updated: 2023/06/20

TRC

Product number: A604720
Product name: 5-Amino-2,4-dichloropyrimidine
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: A604720
Product name: 5-Amino-2,4-dichloropyrimidine
Packaging: 10g
Price: $160
Updated: 2021/12/16

Matrix Scientific

Product number: 073493
Product name: 5-Amino-2,4-dichloropyrimidine
Purity: 95+%
Packaging: 25g
Price: $178
Updated: 2021/12/16

AK Scientific

Product number: B868
Product name: 2,4-Dichloropyrimidin-5-amine
Packaging: 5g
Price: $109
Updated: 2021/12/16

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2,4-Dichloro-5-aminopyrimidine Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

A pyrimidinamine derivative as Plk1 inhibitors

Synthesis

49845-33-2

5177-27-5

General procedure for the synthesis of 5-amino-2,4-dichloropyrimidine from 2,4-dichloro-5-nitropyrimidine: 2,4-dichloro-5-nitropyrimidine (1.0 eq.) and iron powder (6.0 eq.) were formulated in acetic acid to form a non-homogeneous reaction system at a concentration of 0.4 M, and the reaction was carried out for 14 hours at room temperature with vigorous stirring. Upon completion of the reaction, the reaction mixture was thermally filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was washed with methanol (MeOH) and the volatile solvent was subsequently evaporated under reduced pressure. The resulting residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated sodium carbonate (Na2CO3) solution and saturated sodium chloride (NaCl) solution to remove acidic impurities and salts. The organic phase was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product 5-amino-2,4-dichloropyrimidine in 80% yield. The product was analyzed by liquid chromatography-mass spectrometry (LCMS), showing a molecular ion peak (MH+) of 157.0 and a retention time (Rt) of 1.85 min.

References

[1] Patent: US2011/195980, 2011, A1. Location in patent: Page/Page column 17
[2] Patent: WO2011/106168, 2011, A1. Location in patent: Page/Page column 83; 84; 101; 102
[3] Journal of the Chemical Society, 1951, p. 1565,1568
[4] Journal of the Chemical Society, 1953, p. 1646
[5] Chemical and Pharmaceutical Bulletin, 1958, vol. 6, p. 352,354

2,4-Dichloro-5-aminopyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-5-aminopyrimidine Suppliers

Canada 2 China 189 India 10 Japan 1 United Kingdom 9 United States 23 Global 234

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View Lastest Price from 2,4-Dichloro-5-aminopyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,4-Dichloro-5-aminopyrimidine 5177-27-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Shaanxi Dideu Medichem Co. Ltd

Product: 5-amino-2,4-dichloropyrimidine 5177-27-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,4-Dichloro-5-aminopyrimidine 5177-27-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

5177-27-5, 2,4-Dichloro-5-aminopyrimidineRelated Search:

2',4'-Dichloroacetophenone 1,2-Dichloro-4-(chloromethyl)benzene Dichloroethane Glycine 6-Aminocaproic acid 3-Aminophenol ALTRENOGEST EC 2.6.1.2 2,4-Dichloropyrimidine Acetaminophen 5-Amino-2-chloropyrimidine Tris(hydroxymethyl)aminomethane 2,4-Dichloro-6-methyl-5-nitropyrimidine 2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE 2,4,6-TRICHLORO-5-NITROPYRIMIDINE 2,6-Dichloro-4-aminopyrimidine 2,4-Dichloro-5-nitropyrimidine 2,4-Dichloro-5-(1H-pyrazol-1-yl)pyrimidine

2,4-DICHLORO-PYRIMIDIN-5-YLAMINE

2,4-DICHLORO-5-AMINOPYRIMIDINE

5-AMINO-2,4-DICHLOROPYRIMIDINE

2,4-DICHLOROPYRIMIDIN-5-AMINE

5-Amino-2,4-dichloropyrimidine ,98%

2,4-Dichloro-5-pyrimidinamine

5-AMino-2,4-dichloropyriMidine 97%

2,4-di chloro-5-aMinoMpyriMidine

5-Pyrimidinamine, 2,4-dichloro-

5-Amino-2,4-dichL

5-Amino-2,4-dichloropyrimidine,97%

2,4-Dichloropyrimidine-5-amine

2,4-dichlorpyrimidin-5-amin

4-Dichloro-5-aminopyrimidine

2,4-Dichloropyrimidin-5-amine 97%

5177-27-5

Heterocycle-Pyrimidine series

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

pharmacetical

Amines