ChemicalBook > CAS DataBase List > Z-AIB-OH

Z-AIB-OH

Product Name: Z-AIB-OH
CAS No.: 15030-72-5
Chemical Name: Z-AIB-OH
Synonyms: Z-Aib;Z-AIB-OH;Cbz-Aib-OH;NSC 164086;Z-AIB-OH,98%;Cbz-L-Aib-OH;Z-a-Me-Ala-OH;N-Cbz-2-methyL;Z-ALPHA-ME-ALA-OH;Z-2-METHYLALANINE
CBNumber: CB7448841
Molecular Formula: C12H15NO4
Formula Weight: 237.25
MOL File: 15030-72-5.mol

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Z-AIB-OH Property

Melting point:: 65-69 °C(lit.)
Boiling point:: 379.78°C (rough estimate)
Density: 1.215
refractive index: 1.5200 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: soluble in Methanol
form: Powder
pka: 4.09±0.10(Predicted)
color: White
BRN: 2218009
InChI: InChI=1S/C12H15NO4/c1-12(2,10(14)15)13-11(16)17-8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H,13,16)(H,14,15)
InChIKey: QKVCSJBBYNYZNM-UHFFFAOYSA-N
SMILES: C(O)(=O)[C@](C)(C)NC(OCC1=CC=CC=C1)=O

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 24/25-26
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 370940
Product name: Z-Aib-OH
Purity: technical grade
Packaging: 5g
Price: $60.3
Updated: 2025/07/31

TCI Chemical

Product number: C2761
Product name: 2-(Carbobenzoxyamino)isobutyric Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: C2761
Product name: 2-(Carbobenzoxyamino)isobutyric Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $105
Updated: 2025/07/31

TRC

Product number: C227943
Product name: N-Cbz-2-amino-2-methylpropanoicAcid
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 260717
Product name: Z-alpha-aminoisobutyric acid
Packaging: 2g
Price: $333
Updated: 2021/12/16

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Z-AIB-OH Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

62-57-7

501-53-1

15030-72-5

The general procedure for the synthesis of Cbz-2-aminoisobutyric acid from 2-aminoisobutyric acid and benzyl chloroformate was as follows: to an aqueous solution (1 L) containing 2-aminoisobutyric acid (50 g, 0.49 mmol) and sodium carbonate (Na2CO3, 156 g, 1.47 mol), benzyl chloroformate (CbzCl, 91 g, 1.47 mmol) was slowly added over 15 min at 0 °C. 0.54 mmol) to a dioxane solution (500 mL). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the aqueous layer was separated and retained by extraction with ether (Et2O, 2 x 500 mL). The aqueous layer was acidified with concentrated hydrochloric acid (cHCl) to pH=1 and then extracted with ethyl acetate (EtOAc, 2 × 500 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford a white solid Cbz-2-aminoisobutyric acid (111 g, 97% yield), which could be used for the next reaction without further purification.

References

[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 2, p. 533 - 548
[2] Patent: WO2013/114250, 2013, A1. Location in patent: Page/Page column 163
[3] Helvetica Chimica Acta, 2011, vol. 94, # 6, p. 993 - 1011
[4] Tetrahedron, 1982, vol. 38, # 14, p. 2165 - 2182
[5] Helvetica Chimica Acta, 1988, vol. 71, p. 140 - 154

Z-AIB-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Z-AIB-OH manufacturers

Career Henan Chemical Co

Product: Z-AIB-OH 15030-72-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

15030-72-5, Z-AIB-OHRelated Search:

Z-ASN-ONP Z-ASP(OTBU)-OH DCHA Z-ABU-OH Z-ALA-OME Z-ALA-OSU Z-Aib-OSu 2-(4-Methylphenyl)propanoic acid Propanoic acid,2-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]dithio]-2-methyl- Propanoic acid, 2-[[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]dithio]-2-methyl- Z-AIB-OH 1-(Cbz-amino)cyclopropanecarboxylic acid Fmoc-Aib-OH H-D-Aib-OH 2-Aminoisobutyric Acid Boc-Aib-OH N-ME-AIB-OH,N-ME-AIB-OH HCL H-AIB-OH,H-DL-3-AIB-OH,H-DL-BETA-AIB-OH boc-n-me-aib-oh

Z-AIB-OH

Z-ALPHA-ME-ALA-OH

Z-ALPHA-METHYLALANINE

Z-ALPHA-AMINOISOBUTYRIC ACID

Z-2-METHYLALANINE

Z-2-AMINOISOBUTYRIC ACID

N-ALPHA-CARBOBENZOXY-ALPHA-AMINOISOBUTYRIC ACID

N-CARBOBENZYLOXY-2-METHYLALANINE

RARECHEM AL CF 0964

2-(Benzyloxycarbonylamino)-2-methylpropionic acid

2-[(Benzyloxycarbonyl)amino]isobutyric acid

Cbz-Aib-OH

N-(Benzyloxycarbonyl)-2,2-dimethylglycine

N-Carbobenzyloxy-2-methylalanine,99%

N-CARBOBENZYLOXY-2-METHYLALANINE, TECH.

CBZ-2-AMINOISOBUTYRIC ACID

Z-Aib-OH(Z-α-aMinoisobutyric acid)

N-Cbz-2-aMino-2-Methylpropanoic acid

2-[(Benzyloxycarbonyl)amino]-2-methylpropanoic acid

NSC 164086

Z-a-Me-Ala-OH

N-Cbz-2-Methylalanine

2-(Cbz-aMino)-2-Methylpropanoic acid

Alanine,2-methyl-N-[(phenylmethoxy)carbonyl]-

Z-α-aminoisobutyric acid

Z-AIB-OH,98%

2-(Carbobenzoxyamino)isobutyric Acid

Cbz-L-Aib-OH

Z-α-aminoisobutyric acid≥ 99% (HPLC)

Z-α-methylalanine

2-methyl-2-(phenylmethoxycarbonylamino)propanoic acid

N-Cbz-2-methyL

2-methyl-2-(phenylmethoxycarbonylamino)propanoicaci

2-(Cbz-amino)isobutyric Acid

N-Benzyloxycarbonyl-alpha-methylalanine

N-Cbz-alpha-methylalanine

Z-AIB-OH USP/EP/BP

Z-Aib

N-Cbz-2-amino-2-methylpropanoic acid 98%

15030-72-5

C6H5CH2O2CNHCCH32CO2H

Alanine Derivatives

Specialty Synthesis

Peptide Synthesis

Unnatural Amino Acid Derivatives