ChemicalBook > CAS DataBase List > 4-Bromoisoquinoline

4-Bromoisoquinoline

Product Name: 4-Bromoisoquinoline
CAS No.: 1532-97-4
Chemical Name: 4-Bromoisoquinoline
Synonyms: NSC 56333;4-BromoisoquinoL;4-Bromoisoquinoli;4-Bromoisquinoline;4-bromoisoqunoline;4-BROMOISOQUINOLINE;Isoquinoline, 4-broMo-;LABOTEST-BB LT01143353;4-Bromoisoquinoline >4-Isoquinolinyl Bromide
CBNumber: CB7457317
Molecular Formula: C9H6BrN
Formula Weight: 208.05
MOL File: 1532-97-4.mol

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4-Bromoisoquinoline Property

Melting point:: 40-43 °C (lit.)
Boiling point:: 280-285 °C (lit.)
Density: 1.5617 (rough estimate)
refractive index: 1.6641 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform, Methanol
pka: 3.30±0.10(Predicted)
form: Crystalline Solid
color: White to light beige
BRN: 114431
InChI: InChI=1S/C9H6BrN/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H
InChIKey: SCRBSGZBTHKAHU-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC=C2)C(Br)=CN=1
CAS DataBase Reference: 1532-97-4(CAS DataBase Reference)
NIST Chemistry Reference: Isoquinoline, 4-bromo-(1532-97-4)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-21/22-20/21/22
Safety Statements: 26-37/39-36/37/39-22-36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B70202
Product name: 4-Bromoisoquinoline
Purity: 98%
Packaging: 10g
Price: $69.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: B70202
Product name: 4-Bromoisoquinoline
Purity: 98%
Packaging: 25g
Price: $142.12
Updated: 2025/07/31

TCI Chemical

Product number: B0930
Product name: 4-Bromoisoquinoline
Purity: >98.0%(GC)
Packaging: 10g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: B0930
Product name: 4-Bromoisoquinoline
Purity: >98.0%(GC)
Packaging: 25g
Price: $138
Updated: 2025/07/31

TRC

Product number: B684488
Product name: 4-Bromoisoquinoline
Packaging: 1g
Price: $50
Updated: 2021/12/16

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4-Bromoisoquinoline Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Shows selective inhibition of cAMP-dependent protein kinase

Preparation

2-Alkynyl benzyl azides could smoothly undergo an electrocyclic reaction catalyzed by palladium to afford either 4-bromoisoquinoline or 4-bromoisquinolones selectively under different conditions. 4-Bromoisoquinoline was synthesised in the presence of PdBr2/CuBr2/LiBr in MeCN, and 4-bromoisoquinolone was selectively produced with PdBr2/CuBr2/HOAc in CH2ClCH2Cl[1].

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 10, p. 409, 1973 DOI: 10.1002/jhet.5570100326

Synthesis

119-65-3

1532-97-4

Synthesis of Intermediate-12: 3-Bromoisoquinoline: To a stirred solution of isoquinoline (24 g, 186 mmol) in acetic acid (50 mL) was slowly added N-bromosuccinimide (NBS, 36.2 g, 204.6 mmol) at room temperature. The reaction mixture was heated to 100 °C and the reaction was stirred at this temperature overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by fast column chromatography (eluent: 5% ethyl acetate/hexane) to give 4-bromoisoquinoline (9.2 g, 23.8% yield) as an oil.

References

[1] Hong-ping Zhang, Hongzhan Xiao, Hong‐Yan Li. “A Selective Synthesis of 4-Bromoisoquinoline and 4-Bromoisquinolone.” Journal of Chemical Research-s (2013).

4-Bromoisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

4-Isoquinolineboronic acid ISOQUINOLINE-4-BORONIC ACID 2,2-DIMETHYLPROPANEDIOL-1,3 CYCLIC ESTER

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View Lastest Price from 4-Bromoisoquinoline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Bromoisoquinoline 1532-97-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Bromoisoquinoline 1532-97-4
Price: US $30.00-10.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-14

Henan Fengda Chemical Co., Ltd

Product: 4-Bromoisoquinoline 1532-97-4
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-24

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LABOTEST-BB LT01143353

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4-Isoquinolinyl Bromide

NSC 56333

4-Bromoisoquinoline ,98%

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4-Bromoisoquinoline 98%

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4-BromoisoquinoL

4-Bromoisoquinoline ISO 9001：2015 REACH

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1532-97-4

1632-97-4

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Isoquinolines

Building Blocks

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Isoquinoline

Organohalides

Halogenated Heterocycles

Heterocyclic Building Blocks

Isoquinolines

IsoquinolinesBuilding Blocks

Aromatics Compounds

Aromatics

Inhibitors

Quinolines, Isoquinolines & Quinoxalines

Quinolines, Quinazolines and derivatives

Quinolines, Isoquinolines & Quinoxalines

Quinoline&Isoquinoline

Isoquinoline Derivertives

Halides

Heterocycles