Fipronil

ChemicalBook > CAS DataBase List > Fipronil

Product Name: Fipronil
CAS No.: 120068-37-3
Chemical Name: Fipronil
Synonyms: Termidor;Fipronil 95%;ipronil;Frontline Spot-on;Fluocyanobenpyrazole;5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile;REGENT;PRINCE;FIPRONIL;m&b46030
CBNumber: CB7461570
Molecular Formula: C12H4Cl2F6N4OS
Formula Weight: 437.15
MOL File: 120068-37-3.mol

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Fipronil Property

Melting point:: 200-201°C
Boiling point:: 510.1±50.0 °C(Predicted)
Density: 1.477-1.626
vapor pressure: 3.7×10^-7 Pa (25 °C)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: 250 mg/mL (571.89 mM)
pka: -5.86±0.20(Predicted)
Water Solubility: 1.9-2.4 mg 1l^-1 (20 °C）
color: White to Light yellow
λmax: 208nm(H2O)(lit.)
Merck: 14,4085
BRN: 8090115
LogP: 4.000
CAS DataBase Reference: 120068-37-3(CAS DataBase Reference)
EPA Substance Registry System: Fipronil (120068-37-3)

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Safety

Hazard Codes: T,N
Risk Statements: 23/24/25-48/25-50/53-55-57-36
Safety Statements: 26-36/37/39-45-60-61-36/37-28
RIDADR: 2588
WGK Germany: 3
RTECS: UQ4430250
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29331990
Hazardous Substances Data: 120068-37-3(Hazardous Substances Data)
Toxicity: LD50 in rats (mg/kg): 100 orally; >2000 dermally (Colliot); in mice (mg/kg): 32 i.p. (Cole)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 46451
Product name: Fipronil
Purity: PESTANAL
Packaging: 100mg
Price: $251
Updated: 2024/03/01

Sigma-Aldrich

Product number: 16785
Product name: Fipronil
Purity: certified reference material, TraceCERT
Packaging: 50mg
Price: $117
Updated: 2024/03/01

TCI Chemical

Product number: F0822
Product name: Fipronil
Packaging: 1G
Price: $124
Updated: 2024/03/01

TCI Chemical

Product number: F0822
Product name: Fipronil
Packaging: 5G
Price: $372
Updated: 2024/03/01

Cayman Chemical

Product number: 24128
Product name: Fipronil
Purity: ≥95%
Packaging: 50mg
Price: $32
Updated: 2024/03/01

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Fipronil Chemical Properties,Usage,Production

Description

Fipronil is a white powder with a mouldy odour. It has a low solubility in water and is a slow-acting poison. It does not bind strongly with soil, and the half-life of fipronil– sulphone is 34 days. Fipronil is a broadspectrum insecticide of the phenylpyrazole group. Fipronil was first used extensively for the control of ants, beetles, cockroaches, fleas; ticks, termites, mole crickets, thrips, rootworms, weevils, flea of pets, field pest of corn, golf courses, and commercial turf, and other insects. Fipronil was first used in the United States in 1996. Fipronil is a topical insecticide. It kills adult fleas and larvae, ticks, and chewing lice. As a liquid, fipronil is applied on the back side skin of dogs and cats. Reports indicate that some animals do become hypersensitive (allergic) to fipronil.

Chemical Properties

White crystalline solid.

Chemical Properties

White SOlid

Uses

antifungal

Uses

Pesticide.

Uses

A broad spectrum insecticide which actively disrupts the CNS of contacted insects by blocking the passage of chloride ions through GABA receptors.

Uses

Fipronil is used for the control of a wide range of insect species in rice, cereals, corn, cotton, top fruit, sugar beet, sugar cane, oilseed rape, many vegetables and other high-value crops. It also has a veterinary use as an ectoparasiticide.

Definition

ChEBI: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile is a member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively. It is a nitrile, a dichlorobenzene, a primary amino compound, a member of pyrazoles, a sulfoxide and a member of (trifluoromethyl)benzenes.

Agricultural Uses

Insecticide, Veterinary medicine: Not approved for use in EU countries. Fipronil was introduced into the U.S. in 1996 for use in animal health and indoor pest control. It is the constituent of many products for controlling a wide spectrum of domestic animal and residential pests.

Trade name

BES® 602; CEASEFIRE®; CHIPCO®; COMBAT®; FRONTLINE; MB-46030®; H&G®; ICON®; MAXFORCE® ANT STATION; MAXFORCE® ROACH STATION; REGENCY SOFION®; REGENT®; REGENT® 500-FS; TERMIDOR® L VI-NIL

Pharmacology

Fipronil is a phenylpyrazole, the mode of action of which is to inhibit nerve transmission in arthropods by blocking γ -aminobutyric acid-gated chloride channels. Fipronil is available as spray and spot-on formulations to control fleas and ticks on cats and dogs. The adulticidal activity of fipronil accounts for the majority of its activity, although additional activity against flea eggs and larvae results from the presence of fipronil on hairs and debris shed into the environment from treated pets.
Autohistoradiography studies (11) into the cutaneous distribution of 14C-fipronil in the cat and dog following spot-on administration demonstrated that radioactivity was restricted principally to the stratum corneum, the viable epidermis, and the pilosebaceous units. Following its slow release from sebaceous glands, fipronil migrates in the sebum covering the skin and hairs by passive diffusion and was shown to persist on hair for up to 2 months after treatment.

Potential Exposure

Pyrazole/phenylpyrazole/organofluor ine insecticide; veterinary medicine. Fipronil was intro duced into the United States in 1996 for use in animal health and indoor pest control. It is the constituent of many products for controlling a wide spectrum of domestic ani mal and residential pests. Banned for use in EU.

Metabolic pathway

Through the abiotic degradation of fipronil in aqueous solution and on the soil surface, 5-amino-3- carbamoyl-1-[2,6-dichloro-4-(trifluoromethyl)-phenyl]-4- [(trifluoromethyl)sulfinyl]pyrazole is the only hydrolysis product detected. Fipronil in acidic aqueous solution exposed under a xenon lamp degrades with the concomitant appearance of 5-amino-3-cyano-1-[2,6- dichloro-4-(trifluoromethyl)-phenyl]-4- (trifluoromethyl)pyrazole and 5-amino-3-cyano-1-[2,6- dichloro-4-(trifluoromethyl)phenyl]pyrazole-4-sulfonic acid. Under field conditions, when fipronil is applied in formulation, four metabolites which include one product resulting from reduction on the sulfur atom of fipronil are detected.

Shipping

UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2902 Pesticide, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Degradation

Fipronil is stable in water at pH 5 and 7 but is slowly hydrolysed at pH 9 (DT₅₀ 28 days) to the amide (2). It undergoes rapid aqueous photolysis with a DT₅₀ of ﹤0.5 day. The major photodecomposition product in water and on soil surfaces is desulfinyl-fipronil(3) which is formed by extrusion of the SO group. A minor photoproduct in water, on soil and on plant surfaces is the sulfonic acid (4). The mechanisms of these reactions are discussed in a recent paper by Bobe et al. (1998).

Toxicity evaluation

Acute oral LD₅₀ for rats: 100 mg/kg

Waste Disposal

It is the responsibility of chemical waste generators to determine the toxicity and physical properties and of a discarded chemical and to properly identify its classification and certification as a haz ardous waste and to determine the disposal method. United States Environmental Protection Agency guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult and fol low all regional, national, state and local hazardous waste laws to ensure complete and accurate classification and dis posal methods.

Fipronil Preparation Products And Raw materials

Raw materials

Tetrachlorvinphos Ammonium hydroxide 4-Nitrobenzoyl chloride Sodium sulfate 3-Chloroperoxybenzoic acid Column Dimethyl sulfide Pyrazole Concentrated sulfuric acid Ethyl acetate Ethyl 2,3-dicyanopropionate Chloromethane Sodium carbonate

Preparation Products

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View Lastest Price from Fipronil manufacturers

Henan Fengda Chemical Co., Ltd

Product: Fipronil 120068-37-3
Price: US $10.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-28

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Fipronil 120068-37-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.91%
Supply Ability: 200000
Release date: 2024-04-23

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Fipronil 120068-37-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000KG
Release date: 2024-03-26

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