ChemicalBook > CAS DataBase List > 2-Chloro-4-picoline

2-Chloro-4-picoline

Product Name
2-Chloro-4-picoline
CAS No.
3678-62-4
Chemical Name
2-Chloro-4-picoline
Synonyms
2-CHLORO-4-METHYLPYRIDINE;2-CHLOROPICOLINE;2-CHLORO-4-PICOLINE;2-Chloro-4-Pilcoline;4-Picoline, 2-chloro-;2-CHLORO-GAMMA-PICOLINE;2-Chlor-4-methylpyridin;2-Chloro-4-picoline,98%;2-chloro-4-methylpyrdine;2-Chloro-4-mehyl pyridine
CBNumber
CB7481718
Molecular Formula
C6H6ClN
Formula Weight
127.57
MOL File
3678-62-4.mol
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2-Chloro-4-picoline Property

Melting point:
115°C
Boiling point:
194-195 °C (lit.)
Density 
1.142 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.529(lit.)
Flash point:
193 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Liquid
pka
0.94±0.10(Predicted)
Specific Gravity
1.14
color 
Clear colorless to light yellow
InChI
InChI=1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
InChIKey
MZVSTDHRRYQFGI-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(C)=C1
CAS DataBase Reference
3678-62-4(CAS DataBase Reference)
NIST Chemistry Reference
2-Cl-4-(CH3)-pyridine(3678-62-4)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT, IRRITANT-HARMFUL
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
116327
Product name
2-Chloro-4-methylpyridine
Purity
98%
Packaging
5ml
Price
$79.8
Updated
2025/07/31
Sigma-Aldrich
Product number
116327
Product name
2-Chloro-4-methylpyridine
Purity
98%
Packaging
25ml
Price
$136
Updated
2025/07/31
TCI Chemical
Product number
C1992
Product name
2-Chloro-4-methylpyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
C1992
Product name
2-Chloro-4-methylpyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$75
Updated
2025/07/31
TRC
Product number
C369965
Product name
2-Chloro-4-methylpyridine
Packaging
25g
Price
$220
Updated
2021/12/16
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2-Chloro-4-picoline Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid.

Uses

2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.

General Description

2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.

Synthesis

695-34-1

3678-62-4

a) Sodium nitrite (13.88 g, 200 mmol) was slowly added to a concentrated hydrochloric acid (200 mL) solution of 2-amino-4-methylpyridine (15.0 g, 139 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was poured into ice (500 g). The pH of the mixture was adjusted using concentrated ammonia to 8.0. Subsequently, the mixture was extracted with ether (3 x 300 mL). The combined ether layers were washed sequentially with deionized water (2 × 200 mL) and saturated brine (200 mL). The organic layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-chloro-4-methylpyridine (10.3 g, 58% yield) as a pale yellow oil. Mass spectrum (electrospray ionization) m/e 127.8 (M + H)+.

References

[1] Patent: US2002/91264, 2002, A1
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 2791 - 2796
[3] Acta Chemica Scandinavica, 1992, vol. 46, # 2, p. 157 - 162
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 2791 - 2796
[5] Patent: CN107151229, 2017, A. Location in patent: Paragraph 0023; 0027

2-Chloro-4-picoline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-4-picoline Suppliers

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View Lastest Price from 2-Chloro-4-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-4-picoline 3678-62-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Chloro-4-picoline 3678-62-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-29
Henan Aochuang Chemical Co.,Ltd.
Product
2-Chloro-4-picoline 3678-62-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12

3678-62-4, 2-Chloro-4-picolineRelated Search:

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