2-Chloro-4-picoline

Product Name: 2-Chloro-4-picoline
CAS No.: 3678-62-4
Chemical Name: 2-Chloro-4-picoline
Synonyms: 2-CHLORO-4-METHYLPYRIDINE;2-CHLOROPICOLINE;2-CHLORO-4-PICOLINE;2-Chloro-4-Pilcoline;4-Picoline, 2-chloro-;2-CHLORO-GAMMA-PICOLINE;2-Chlor-4-methylpyridin;2-Chloro-4-picoline,98%;2-chloro-4-methylpyrdine;2-Chloro-4-mehyl pyridine
CBNumber: CB7481718
Molecular Formula: C6H6ClN
Formula Weight: 127.57
MOL File: 3678-62-4.mol

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2-Chloro-4-picoline Property

Melting point:: 115°C
Boiling point:: 194-195 °C (lit.)
Density: 1.142 g/mL at 25 °C (lit.)
refractive index: n20/D 1.529(lit.)
Flash point:: 193 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid
pka: 0.94±0.10(Predicted)
Specific Gravity: 1.14
color: Clear colorless to light yellow
InChI: InChI=1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
InChIKey: MZVSTDHRRYQFGI-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C)=C1
CAS DataBase Reference: 3678-62-4(CAS DataBase Reference)
NIST Chemistry Reference: 2-Cl-4-(CH3)-pyridine(3678-62-4)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39
WGK Germany: 3
HazardClass: IRRITANT, IRRITANT-HARMFUL
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 116327
Product name: 2-Chloro-4-methylpyridine
Purity: 98%
Packaging: 5ml
Price: $79.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 116327
Product name: 2-Chloro-4-methylpyridine
Purity: 98%
Packaging: 25ml
Price: $136
Updated: 2025/07/31

TCI Chemical

Product number: C1992
Product name: 2-Chloro-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: C1992
Product name: 2-Chloro-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $75
Updated: 2025/07/31

TRC

Product number: C369965
Product name: 2-Chloro-4-methylpyridine
Packaging: 10g
Price: $125
Updated: 2021/12/16

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2-Chloro-4-picoline Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid.

Uses

2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.

General Description

2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.

Synthesis

695-34-1

3678-62-4

a) Sodium nitrite (13.88 g, 200 mmol) was slowly added to a concentrated hydrochloric acid (200 mL) solution of 2-amino-4-methylpyridine (15.0 g, 139 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was poured into ice (500 g). The pH of the mixture was adjusted using concentrated ammonia to 8.0. Subsequently, the mixture was extracted with ether (3 x 300 mL). The combined ether layers were washed sequentially with deionized water (2 × 200 mL) and saturated brine (200 mL). The organic layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-chloro-4-methylpyridine (10.3 g, 58% yield) as a pale yellow oil. Mass spectrum (electrospray ionization) m/e 127.8 (M + H)+.

References

[1] Patent: US2002/91264, 2002, A1
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 2791 - 2796
[3] Acta Chemica Scandinavica, 1992, vol. 46, # 2, p. 157 - 162
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 2791 - 2796
[5] Patent: CN107151229, 2017, A. Location in patent: Paragraph 0023; 0027

2-Chloro-4-picoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-4-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-4-picoline 3678-62-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Chloro-4-picoline 3678-62-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-29

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloro-4-picoline 3678-62-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

3678-62-4, 2-Chloro-4-picolineRelated Search:

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2-CHLORO-4-METHYLPYRIDINE

2-chloro-4-methylpyrdine

2-CHLORO-4-PICOLINE 2-CHLORO-4-METHYLPYRIDINE

2-CHLORO-4-METHYLPYRIDINE (2-CHLORO-4-PICOLINE)

HCPY1902-Chloro-4-picoline

2-Chloro-4-methylpyridine(2-Chloropicoline)

2-Chloro-4-picoline,98%

2-Chloro-4-Pilcoline

2-Chloro-4-methylpyridine &gt

5-bromopyridine-4-carbonitrile

2-Chloro-4-picoline ISO 9001：2015 REACH

2-Chloro-4-Methyle pyridine

2-Chloro-4-methylpyridine, 98%

3678-62-4

222-951-2

C6H6ClN

Building Blocks

HETERO CHLORIDE

Halopyridines

Chloropyridines

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Pyridine

pyridine derivative

pyridine series

Chloropyridines

Halopyridines

Halides

Pyridines