2-Chloro-4-picoline
- Product Name
- 2-Chloro-4-picoline
- CAS No.
- 3678-62-4
- Chemical Name
- 2-Chloro-4-picoline
- Synonyms
- 2-CHLORO-4-METHYLPYRIDINE;2-CHLOROPICOLINE;2-CHLORO-4-PICOLINE;2-Chloro-4-Pilcoline;4-Picoline, 2-chloro-;2-CHLORO-GAMMA-PICOLINE;2-Chlor-4-methylpyridin;2-Chloro-4-picoline,98%;2-chloro-4-methylpyrdine;2-Chloro-4-mehyl pyridine
- CBNumber
- CB7481718
- Molecular Formula
- C6H6ClN
- Formula Weight
- 127.57
- MOL File
- 3678-62-4.mol
2-Chloro-4-picoline Property
- Melting point:
- 115°C
- Boiling point:
- 194-195 °C (lit.)
- Density
- 1.142 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.529(lit.)
- Flash point:
- 193 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- pka
- 0.94±0.10(Predicted)
- Specific Gravity
- 1.14
- color
- Clear colorless to light yellow
- InChI
- InChI=1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
- InChIKey
- MZVSTDHRRYQFGI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C)=C1
- CAS DataBase Reference
- 3678-62-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Cl-4-(CH3)-pyridine(3678-62-4)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 116327
- Product name
- 2-Chloro-4-methylpyridine
- Purity
- 98%
- Packaging
- 5ml
- Price
- $79.8
- Updated
- 2025/07/31
- Product number
- 116327
- Product name
- 2-Chloro-4-methylpyridine
- Purity
- 98%
- Packaging
- 25ml
- Price
- $136
- Updated
- 2025/07/31
- Product number
- C1992
- Product name
- 2-Chloro-4-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- C1992
- Product name
- 2-Chloro-4-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- C369965
- Product name
- 2-Chloro-4-methylpyridine
- Packaging
- 10g
- Price
- $125
- Updated
- 2021/12/16
2-Chloro-4-picoline Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liquid.
Uses
2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.
General Description
2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.
Synthesis
695-34-1
3678-62-4
a) Sodium nitrite (13.88 g, 200 mmol) was slowly added to a concentrated hydrochloric acid (200 mL) solution of 2-amino-4-methylpyridine (15.0 g, 139 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was poured into ice (500 g). The pH of the mixture was adjusted using concentrated ammonia to 8.0. Subsequently, the mixture was extracted with ether (3 x 300 mL). The combined ether layers were washed sequentially with deionized water (2 × 200 mL) and saturated brine (200 mL). The organic layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-chloro-4-methylpyridine (10.3 g, 58% yield) as a pale yellow oil. Mass spectrum (electrospray ionization) m/e 127.8 (M + H)+.
References
[1] Patent: US2002/91264, 2002, A1
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 2791 - 2796
[3] Acta Chemica Scandinavica, 1992, vol. 46, # 2, p. 157 - 162
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 2791 - 2796
[5] Patent: CN107151229, 2017, A. Location in patent: Paragraph 0023; 0027
2-Chloro-4-picoline Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-4-picoline Suppliers
- Tel
- --
- Fax
- --
- brian@chordip.com
- Country
- Jordan
- ProdList
- 704
- Advantage
- 51
View Lastest Price from 2-Chloro-4-picoline manufacturers
- Product
- 2-Chloro-4-picoline 3678-62-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2-Chloro-4-picoline 3678-62-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-29
- Product
- 2-Chloro-4-picoline 3678-62-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12