4-Bromo-3-fluorobenzoic acid

Product Name: 4-Bromo-3-fluorobenzoic acid
CAS No.: 153556-42-4
Chemical Name: 4-Bromo-3-fluorobenzoic acid
Synonyms: BUTTPARK 20\01-57;4-Bromo-3-fluorobenzoic;4-BROMO-3-FLUOROBENZOIC ACID;4-bromo-3-fluro benzoic acid;3-Fluoro-4-Bromo Benzoic Acid;Benzoic acid, 4-bromo-3-fluoro-;4-Bromo-3-fluorobenzoic acid 98%;4-Bromo-3-fluorobenzoic acid, 98+%;3-Fluoride-4-Bromine Benzoic Acids
CBNumber: CB7496655
Molecular Formula: C7H4BrFO2
Formula Weight: 219.01
MOL File: 153556-42-4.mol

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4-Bromo-3-fluorobenzoic acid Property

Melting point:: 207 °C
Boiling point:: 296.1±25.0 °C(Predicted)
Density: 1.789±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder
pka: 3.63±0.10(Predicted)
color: Off white to cream
InChI: InChI=1S/C7H4BrFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11)
InChIKey: RMYOGXPGIDWJLU-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(Br)C(F)=C1
CAS DataBase Reference: 153556-42-4(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 4-bromo-3-fluoro- (153556-42-4)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-36-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B691998
Product name: 4-Bromo-3-fluorobenzoicacid
Packaging: 5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J92224
Product name: 4-Bromo-3-fluorobenzoicacid
Packaging: 500g
Price: $450
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB36910
Product name: 4-Bromo-3-fluorobenzoic acid
Packaging: 250g
Price: $560
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0023081
Product name: 4-BROMO-3-FLUOROBENZOIC ACID
Purity: 95.00%
Packaging: 5G
Price: $779.63
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0023081
Product name: 4-BROMO-3-FLUOROBENZOIC ACID
Purity: 95.00%
Packaging: 25G
Price: $1103.03
Updated: 2021/12/16

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4-Bromo-3-fluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White solid powder

Uses

4-Bromo-3-fluorobenzoic acid is an important chemical raw material and can be used to prepare a variety of drugs (such as the anticancer drug benzamide).

Synthesis

452-74-4

153556-42-4

The general procedure for the synthesis of 3-fluoro-4-bromobenzoic acid from 3-fluoro-4-bromotoluene was as follows: potassium permanganate (66.0 g, 0.42 mol) was added to a mixed solution of pyridine and water (1:1 ratio, 200 mL) containing 1-bromo-2-fluoro-4-methylbenzene (20.0 g, 0.10 mol) in batches. The reaction mixture was stirred at 90 °C for 3 hours. After completion of the reaction, it was cooled to room temperature and filtered through a diatomaceous earth pad. The diatomaceous earth pad was washed sequentially with 3N sodium hydroxide solution (500 mL) and water (400 mL). Subsequently, ethanol was removed by distillation under reduced pressure and the residue was acidified to pH=2 with 6N hydrochloric acid to produce a white precipitate. The precipitate was filtered and dried to give 4-bromo-3-fluorobenzoic acid as a white solid (17.0 g, 73% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 10, p. 1257 - 1260
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 14, p. 2973 - 2984
[3] Patent: WO2011/21209, 2011, A1. Location in patent: Page/Page column 38
[4] Patent: US2012/101099, 2012, A1. Location in patent: Page/Page column 13; 14
[5] Patent: WO2006/64251, 2006, A1. Location in patent: Page/Page column 80

4-Bromo-3-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-fluorobenzoic acid Suppliers

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View Lastest Price from 4-Bromo-3-fluorobenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-3-fluorobenzoic acid 153556-42-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-11

Speranza Chemical Co., Ltd.

Product: 4-Bromo-3-fluorobenzoic acid 153556-42-4
Price: US $110.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20 tons
Release date: 2019-12-24

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Bromo-3-fluorobenzoic acid 153556-42-4
Price: US $0.10/KG
Min. Order: 0.1KG
Purity: 98%
Supply Ability: 200TONS
Release date: 2019-12-24

153556-42-4, 4-Bromo-3-fluorobenzoic acidRelated Search:

Florfenicol 3,5-Dimethylbenzoic acid 4-Bromofluorobenzene 4-Bromo-2-methylpyridine 4-BROMO-3-CHLOROPHENOL 4-Bromo-2-fluoroanisole Transfluthrin 1,3-Difluorobenzene 4-Bromomethylbenzoic acid 4-Bromobenzoic acid 4-Bromo-2,6-dimethylaniline 4-Bromo-3-fluorobenzonitrile 4-Bromo-3-fluorobenzaldehyde 4-Bromo-2-chlorobenzonitrile 4-Bromo-3-methylphenol 4-BROMO-2-METHYLANISOLE 4-Bromo-2-fluorobenzotrifluoride 4-Bromo-2-methyl-benzaldehyde

3-Fluoride-4-Bromine Benzoic Acids

4-BROMO-3-FLUOROBENZOIC ACID

BUTTPARK 20\01-57

3-Fluoro-4-Bromo Benzoic Acid

4-Bromo-3-fluorobenzoic acid, 98+%

4-Bromo-3-fluorobenzoic acid 98%

4-Bromo-3-fluorobenzoic

Benzoic acid, 4-bromo-3-fluoro-

4-bromo-3-fluro benzoic acid

153556-42-4

Multisubstituted Benzene

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzoic acid

Miscellaneous

Acids & Esters

Bromine Compounds

Fluorine Compounds

blocks

Bromides

Carboxes

FluoroCompounds

Fluorin-contained Benzoic acid series

Fluorine series