ChemicalBook > CAS DataBase List > 2,6-Dibromo-4-(trifluoromethoxy)aniline
2,6-Dibromo-4-(trifluoromethoxy)aniline
Uses- Product Name
- 2,6-Dibromo-4-(trifluoromethoxy)aniline
- CAS No.
- 88149-49-9
- Chemical Name
- 2,6-Dibromo-4-(trifluoromethoxy)aniline
- Synonyms
- Riluzole Impurity 2;BroMo Riluzole IMpurity;DBTFMA IMPURITY RLZ52-100;Riluzole Dibromo Impurity;3,5-Dibromo-4-Aminotrifluoromethoxy;6-DibroMo-4-(trifluoroMethoxy)aniline;2,6-Dibromo-4-Trifluromethoxy-Aniline;2,6-dibromo-4-(Trifluomethoxy) Aniline;2-Nitro-4-Bromotrifluoromethoxybenzene;3,5-Dibromo-4-(trifluoromethoxy)aniline
- CBNumber
- CB7777385
- Molecular Formula
- C7H4Br2F3NO
- Formula Weight
- 334.92
- MOL File
- 88149-49-9.mol
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2,6-Dibromo-4-(trifluoromethoxy)aniline Property
- Melting point:
- 70-74 °C(lit.)
- Boiling point:
- 65/0.1mm
- Density
- 2.036±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -0.38±0.10(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C7H4Br2F3NO/c8-4-1-3(14-7(10,11)12)2-5(9)6(4)13/h1-2H,13H2
- InChIKey
- JBSWOEGXMADXOU-UHFFFAOYSA-N
- SMILES
- C1(N)=C(Br)C=C(OC(F)(F)F)C=C1Br
- CAS DataBase Reference
- 88149-49-9(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-60-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29222990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- D3038
- Product name
- 2,6-Dibromo-4-(trifluoromethoxy)aniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $44
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D3038
- Product name
- 2,6-Dibromo-4-(trifluoromethoxy)aniline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $140
- Updated
- 2025/07/31
TRC
- Product number
- D426200
- Product name
- 2,6-Dibromo-4-(trifluoromethoxy)benzenamine
- Packaging
- 50g
- Price
- $340
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 004550
- Product name
- 2,6-Dibromo-4-(trifluoromethoxy)aniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $9
- Updated
- 2021/12/16
Oakwood
- Product number
- 004677
- Product name
- 2,6-Dibromo-4-(trifluoromethoxy)aniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $9
- Updated
- 2021/12/16
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2,6-Dibromo-4-(trifluoromethoxy)aniline Chemical Properties,Usage,Production
Uses
2,6-Dibromo-4-(trifluoromethoxy)benzenamine is used in the synthesis of novel pyridylpyrazole acid derivatives in the preparation of agricultural insecticides.
Chemical Properties
Light pink powder
Uses
2,6-Dibromo-4-(trifluoromethoxy)benzenamine is used in the synthesis of novel pyridylpyrazole acid derivatives in the preparation of agricultural insecticides.
Synthesis
461-82-5
88149-49-9
The general procedure for the synthesis of 2,6-dibromo-4-(trifluoromethoxy)aniline from p-trifluoromethoxyaniline was as follows: first, 156 g of the crystallized mother liquor containing sodium sulfate was filtered into a 250 mL four-necked flask and the stirring apparatus was started. Subsequently, 17.5 g (0.175 mol) of the reagent was slowly added dropwise, followed by 36.5 g of sodium bromide (0.354 mol) and 30 g (99% purity, 0.168 mol) of 4-trifluoromethoxyaniline. The temperature of the reaction system was adjusted to above 30 °C and the dropwise addition of 38 g of 35% hydrogen peroxide solution was started. During the dropwise addition, if the temperature increased to 50 °C, the reaction temperature was controlled between 50 and 55 °C by adjusting the dropwise acceleration of the coolant. After the dropwise addition was completed, the reaction temperature was maintained to drop and the reaction was continued to be held for 3 hours. Upon completion of the reaction, the system was cooled to about 30°C and the filtration operation was carried out. The resulting filter cake was dried to obtain 55.8 g of white crystals of 2,6-dibromo-4-trifluoromethoxyaniline, which was analyzed by high performance liquid chromatography (HPLC) with a purity of 99.6% and a yield of 99.2%.
References
[1] Patent: CN106631839, 2017, A. Location in patent: Paragraph 0022-0033
[2] Organic Letters, 2011, vol. 13, # 20, p. 5636 - 5639
2,6-Dibromo-4-(trifluoromethoxy)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dibromo-4-(trifluoromethoxy)aniline manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 2,6-Dibromo-4-(trifluoromethoxy)aniline 88149-49-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
Hebei Yanxi Chemical Co., Ltd.
- Product
- 2,6-Dibromo-4-(trifluoromethoxy)aniline 88149-49-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- Min.99.5%GC
- Supply Ability
- 20tons
- Release date
- 2023-09-14
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2,6-Dibromo-4-(trifluoromethoxy)aniline 88149-49-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2020-01-16
88149-49-9, 2,6-Dibromo-4-(trifluoromethoxy)anilineRelated Search:
p-Anisaldehyde
4-(Trifluoromethoxy)aniline
4'-Methoxyacetophenone
Aniline
2-(Trifluoromethoxy)aniline
3-Methoxybenzaldehyde
3-(Trifluoromethoxy)aniline
4-Methoxybenzoic acid
4-(Trifluoromethoxy)benzaldehyde
4-(Trifluoromethoxy)chlorobenzene
(Trifluoromethoxy)benzene
Anisole
4'-(Trifluoromethoxy)acetophenone
3-Methoxyacetophenone
p-Trifluoromethoxy phenol
3-(Trifluoromethoxy)bromobenzene
2-Bromo-4-trifluoromethoxyaniline
3,5-Dibromophenol