ChemicalBook > CAS DataBase List > Thalidomide-O-PEG4-Propargyl
Thalidomide-O-PEG4-Propargyl
- Product Name
- Thalidomide-O-PEG4-Propargyl
- CAS No.
- 2098799-77-8
- Chemical Name
- Thalidomide-O-PEG4-Propargyl
- Synonyms
- Thalidomide-PEG4-Propargyl;Thalidomide-O-PEG4-Propargyl;Thalidomide-4-PEG4-O-Propargyl;4-((3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)-;E3 Ligase Ligand-Linker Conjugates,Thalidomide-PEG-4-Propargyl,inhibit,Inhibitor,Thalidomide PEG4 Propargyl,ThalidomidePEG4Propargyl
- CBNumber
- CB78184545
- Molecular Formula
- C24H28N2O9
- Formula Weight
- 488.49
- MOL File
- 2098799-77-8.mol
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Thalidomide-O-PEG4-Propargyl Property
- Boiling point:
- 673.9±55.0 °C(Predicted)
- Density
- 1.320±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, stored under nitrogen
- solubility
- Soluble in Water, DMF, DCM, DMSO
- pka
- 10.70±0.40(Predicted)
- form
- Solid
- color
- White to light yellow
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Safety
- HS Code
- 2933998090
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N-Bromosuccinimide Price
BroadPharm
- Product number
- BP-24423
- Product name
- Thalidomide-O-PEG4-Propargyl
- Purity
- 98%
- Packaging
- 500mg
- Price
- $1930
- Updated
- 2021/12/16
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Thalidomide-O-PEG4-Propargyl Chemical Properties,Usage,Production
Description
Thalidomide-O-PEG4-Propargyl is synthesized compound that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology, Propargyl is reactive with azide molecule in the presence of Cu catalyst.
Uses
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
Cereblon
References
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-998. DOI:10.1016/j.str.2020.07.015
Thalidomide-O-PEG4-Propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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Thalidomide-O-PEG4-Propargyl Suppliers
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View Lastest Price from Thalidomide-O-PEG4-Propargyl manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- Thalidomide-O-PEG4-Propargyl 2098799-77-8
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01
2098799-77-8, Thalidomide-O-PEG4-PropargylRelated Search:
1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)-
Cereblon Ligand 1
E3 Ligase Ligand-Linker Conjugates 21
E3 Ligase Ligand-Linker Conjugates 19
Thalidomide-linker 10
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-
Thalidomide-O-amido-C4-NH2 hydrochloride
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
Thalidomide-O-amido-C8-NH2 hydrochloride
Thalidomide-O-PEG4-Boc
tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate
Thalidomide-linker 13
E3 Ligase Ligand-Linker Conjugates 20