m-Cresol

ChemicalBook > CAS DataBase List > m-Cresol

Uses

Product Name: m-Cresol
CAS No.: 108-39-4
Chemical Name: m-Cresol
Synonyms: 3-METHYLPHENOL;META-CRESOL;Phenol,3-methyl-;m-Cresole;m-Kresol;3-Cresol;M-METHYLPHENOL;m-Cesol;M-CRESOL;m-Toluol
CBNumber: CB7852747
Molecular Formula: C7H8O
Formula Weight: 108.14
MOL File: 108-39-4.mol

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m-Cresol Property

Melting point:: 8-10 °C(lit.)
Boiling point:: 203 °C(lit.)
Density: 1.034 g/mL at 25 °C(lit.)
vapor density: 3.72 (vs air)
vapor pressure: <1 mm Hg ( 20 °C)
refractive index: n20/D 1.541(lit.)
FEMA: 3530 | M-CRESOL
Flash point:: 187 °F
storage temp.: Store below +30°C.
solubility: 23.5g/l; Soluble 2 % in water, soluble in alcohol and oils.
pka: 10.01(at 25℃)
form: Liquid
color: Clear colorless to slight red
Odor: Dry-tarry, medicinal-leathery odor
PH: 5 (20g/l, H2O, 20℃)
explosive limit: 1.06-1.35%, 150°F
Odor Threshold: 0.0001ppm
Odor Type: phenolic
Water Solubility: 20 g/L (20 ºC)
λmax: 273nm(lit.)
JECFA Number: 692
Merck: 14,2579
BRN: 506719
Dielectric constant: 11.5
Exposure limits: ACGIH: TWA 20 mg/m3 (Skin)
NIOSH: IDLH 250 ppm; TWA 2.3 ppm(10 mg/m3)
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, aluminium, aluminium alloys. Air and light sensitive. Hygroscopic.
LogP: 1.96
CAS DataBase Reference: 108-39-4(CAS DataBase Reference)
NIST Chemistry Reference: Phenol, 3-methyl-(108-39-4)
EPA Substance Registry System: m-Cresol (108-39-4)

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Safety

Hazard Codes: T
Risk Statements: 24/25-34-39/23/24/25-23/24/25
Safety Statements: 36/37/39-45-36/37
OEB: B
OEL: TWA: 2.3 ppm (10 mg/m3)
RIDADR: UN 2076 6.1/PG 2
WGK Germany: 1
RTECS: GO6125000
F: 8
Autoignition Temperature: 626 °C
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29071200
Hazardous Substances Data: 108-39-4(Hazardous Substances Data)
Toxicity: LD50 orally in rats: 2.02 g/kg (Deichmann, Witherup)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W353000
Product name: m-Cresol
Purity: ≥98%, FG
Packaging: 1kg
Price: $96.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: W353000
Product name: m-Cresol
Purity: ≥98%, FG
Packaging: 10Kg
Price: $482
Updated: 2024/03/01

Sigma-Aldrich

Product number: W353000
Product name: m-Cresol
Purity: ≥98%, FG
Packaging: 25kg
Price: $885
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.09691
Product name: m-Cresol
Purity: for synthesis
Packaging: 100mL
Price: $61.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.09691
Product name: m-Cresol
Purity: for synthesis
Packaging: 500mL
Price: $94.3
Updated: 2024/03/01

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m-Cresol Chemical Properties,Usage,Production

Uses

m-Cresol is an important organic intermediate (building block) to synthetize substituted aryl products.

Chemical Properties

colourless to light yellow liquid

Chemical Properties

Cresol is a mixture of the three isomeric cresols, o-, m-, and p-cresol. Cresols are slightly soluble in water. m-Isomer: Colorless or yellow liquid with characteristic odor.

Chemical Properties

m-Cresol has a dry, tarry, medicinal–leathery odor. m-Cresol and p-cresol very often occur together and are difficult to separate.

Occurrence

Reported found in beer, coffee, egg, grape, Oriental tobacco, roasted barley, rum, sherry and whiskey.

Uses

m-Cresol is used as a disinfectant and solvent. Lysol^TM disinfectant is a 50% (v/v) mixed-cresol isomer in a soap emulsion formed on mixing with water. The isomer m-cresol is an oily liquid with low volatility. Besides disinfection at solutions of 1–5%, the cresols are used in degreasing compounds, paintbrush cleaners, and additives in lubricating oils. Cresols were once widely used for disinfection of poultry houses, but this use has been discontinued because they cause respiratory problems and abdominal edema in young chicks. m-Cresol has been used in synthetic resins, explosives, petroleum, photographic, paint, and agricultural industries.

Uses

m-Cresol is employed in the preparation of synthetic resins like phenol-formaldehyde resins, disinfectants, and photographic developers. It is used as industrial solvent for dissolving polymers such as polyaniline. It acts as a precursor to vitamin E and antiseptic amylmetacresol. It is used as insuline preservatives.

Uses

Antiseptic; antimicrobial preservative.

Definition

ChEBI: A cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene.

Production Methods

The cresols (cresylic acids) are methyl phenols and generally appear as a mixture of isomers. m-Cresol is prepared from m-toluic acid or obtained from coal tar or petroleum (352, 355, 356). Crude cresol is obtained by distilling “gray phenic acid” at a temperature of ～180–201°C. The m-cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluidine or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.

Preparation

One process involving butylation and separation and followed by dealkylation produces m-cresol and ditertiary butyl p-cresol. From m, p-cresol (which is the main product of the recovery process) pure m-cresol can be obtained by extraction.

Aroma threshold values

Aroma characteristics at 1.0%: phenolic, spicy eugenol-like, medicinal, smoky powdery with a leatherlike note.

Taste threshold values

Taste characteristics at 2 ppm: phenolic, smoky, balsamic, medicinal and spicy eugenol-like

General Description

Colorless liquid with a sweet tarry odor. Sinks and mixes slowly with water.

Air & Water Reactions

Water soluble.

Reactivity Profile

m-Cresol is sensitive to air, light and heat. m-Cresol is also hygroscopic. m-Cresol can react vigorously with strong oxidizers and strong bases. m-Cresol reacts violently with nitric acid, oleum, chlorosulfonic acid, metals and strong acids. If the water content is below approximately 0.3% and the temperature above 248° F, the corrosion of aluminum and its alloys may occur violently. m-Cresol will attack some forms of plastics, coatings and rubber.

Hazard

Questionable carcinogen.

Health Hazard

INHALATION: Mucosal irritation and systemic poisoning EYES: Intense irritation and pain, swelling of conjunctiva, and corneal damage may occur. SKIN: Intense burning, loss of feeling, wrinkling, white discoloration, and softening. Gangrene may occur. INGESTION: Burning sensation in mouth and esophagus. Vomiting may result. Acute exposure by all routes may cause muscular weakness, gastroenteric disturbances, severe depression, collapse. Effects are primarily on CNS and edema of lungs. Injury of spleen and pancreas may occur.

Flammability and Explosibility

Not classified

Contact allergens

Metacresol is contained as a preservative in almost all human insulin. It has been reported as a cause of allergic reaction due to injected insulin.

Safety Profile

v Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by skin contact. Severe eye and skin irritant. An experimental teratogen. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. Flammable when exposed to heat or flame. Moderately explosive in the form of vapor when exposed to heat or flame. See also other cresol entries and PHENOL.

Potential Exposure

Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.

Carcinogenicity

m-Cresol has induced a few papillomas but no carcinomas in tumor studies.

Shipping

UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.

Purification Methods

Separation of the m-and p-cresols requires chemical methods, such as conversion to their sulfonates [Brüchner Anal Chem 75 289 1928]. An equal volume of H2SO4 is added to m-cresol, stirred with a glass rod until solution is complete. Heat for 3hours at 103-105o. Dilute carefully with 1-1.5 volumes of water, heat to boiling point and steam distil until all unsulfonated cresol has been removed. Cool and extract the residue with ether. Evaporate the solution until the boiling point reaches 134o and steam distil off the m-cresol. Another purification method involves distillation, fractional crystallisation from the melt, then redistillation. Free from p-cresol by solution in glacial acetic acid and bromination by about half of an equivalent amount of bromine in glacial acetic acid. The acetic acid is distilled off, then fractional distillation of the residue under vacuum gives bromocresols from which 4-bromo-m-cresol is obtained by crystallisation from hexane. Addition of the bromocresol in glacial acetic acid slowly to a reaction mixture of HI and red phosphorus or (more smoothly) of HI and hypophosphorus acid, in glacial acetic acid, at reflux, removes the bromine. After an hour, the solution is distilled at atmospheric pressure until layers are formed. Then it is cooled and diluted with water. The cresol is extracted with ether, washed with water, NaHCO3 solution and again with water, dried with a little CaCl2 and distilled [Baltzly et al. J Am Chem Soc 77 2522 1955]. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 165o. [Beilstein 6 IV 2035.]

Incompatibilities

Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals.

Waste Disposal

Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.

m-Cresol Preparation Products And Raw materials

Raw materials

o-Xylene Pure m-cresol COKEOVENGAS Phenol crude Isobutylene o-Cresol p-Cresol o-Toluic acid Cresol Aluminum chloride Cobalt naphthenate Cupric oxide p-Cymene Sulfuric acid

Preparation Products

4-tert-Butyl-2,6-dinitro-3-methoxytoluene polyquinoxaline 4,4'-Thiobis(6-tert-butyl-m-cresol) Fenthion Acifluorfen 3-Methyl-4-nitrophenol 3-Phenoxybenzaldehyde METOLCARB 1,1,3-TRIS(2-METHYL-4-HYDROXY-5-TERT-BUTYLPHENYL)BUTANE Emodin 3-methyl-4-propan-2-ylphenol 2-hydroxy-4-methylbenzenesulphonic acid 2,4,6-TRIBROMO-3-METHYLPHENOL Sulphur Brown 4 4-METHYL-2-OXO-2 H-CHROMENE-7-CARBALDEHYDE o-Cresol 3-Hydroxybenzoic acid Acid Orange 67 Fenitrothion 3-PHENOXYTOLUENE p-Cresol 4-Chloro-3-methylphenol 7-BROMOMETHYL-4-METHYL-CHROMEN-2-ONE 2-CHLORO-5-METHYLPHENOL Acid Yellow 199 6-tert-Butyl-m-cresol 3-Hydroxybenzaldehyde ANTIOXIDANT CHROMAFENOZIDE Thymol Fenamiphos 4,7-DIMETHYLCOUMARIN L-Menthol (6-METHYL-BENZOFURAN-3-YL)-ACETIC ACID polyaniline composite film 3-Methyl-4-(methylthio)phenol Disperse Yellow 104

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View Lastest Price from m-Cresol manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: m-Cresol 108-39-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-30

Hebei Chuanghai Biotechnology Co,.LTD

Product: m-Cresol 108-39-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-21

Hebei Mojin Biotechnology Co., Ltd

Product: m-Cresol 108-39-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-11-24

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