ChemicalBook > CAS DataBase List > 1-BENZHYDRYLPIPERAZINE

1-BENZHYDRYLPIPERAZINE

Product Name: 1-BENZHYDRYLPIPERAZINE
CAS No.: 841-77-0
Chemical Name: 1-BENZHYDRYLPIPERAZINE
Synonyms: Diphenylmethylpiperazine;1-(DIPHENYLMETHYL)PIPERAZINE;NSC 35536;norcyclizine;AKOS NCG1-0108;AKOS BBS-00003601;TIMTEC-BB SBB003136;BENZHYDRYLPIPERAZINE;Benzhydrol piperzine;1-BENZHYDRYLPIPERAZINE
CBNumber: CB8117067
Molecular Formula: C17H20N2
Formula Weight: 252.35
MOL File: 841-77-0.mol

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1-BENZHYDRYLPIPERAZINE Property

Melting point:: 90-93 °C
Boiling point:: 185°C/2mmHg(lit.)
Density: 1.0546 (rough estimate)
vapor pressure: 0.001Pa at 20℃
refractive index: 1.5794 (estimate)
Flash point:: 115 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Methanol (Slightly)
pka: 9.05±0.10(Predicted)
form: Crystalline Powder
color: White to light yellow
Water Solubility: 0.45 g/L (20 ºC)
Sensitive: Air Sensitive
BRN: 222773
LogP: 0.6 at 20℃
CAS DataBase Reference: 841-77-0(CAS DataBase Reference)
NIST Chemistry Reference: Benzhydryl piperazine(841-77-0)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TL6465000
F: 34
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3760
Product name: 1-Benzhydrylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: B3760
Product name: 1-Benzhydrylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $251
Updated: 2025/07/31

TRC

Product number: B196950
Product name: 1-Benzhydrylpiperazine
Packaging: 50g
Price: $95
Updated: 2021/12/16

TRC

Product number: B196950
Product name: 1-Benzhydrylpiperazine
Packaging: 250g
Price: $155
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK284350
Product name: 1-Benzhydrylpiperazine
Packaging: 25g
Price: $38
Updated: 2021/12/16

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1-BENZHYDRYLPIPERAZINE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Cinnarizine (C465300) impurity.

Uses

1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.

Uses

1-Benzhydrylpiperazine is an intermediate used in drug synthesis

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006

General Description

1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones.

Flammability and Explosibility

Not classified

Synthesis

110-85-0

776-74-9

841-77-0

General procedure for the synthesis of N-diphenylmethylpiperazine from piperazine and diphenylmethyl bromide: accurately weigh diphenylmethyl bromide (10 g, 41 mmol), piperazine (9 g, 105 mmol), potassium carbonate (K2CO3, 14 g, 101 mmol) and sodium iodide (NaI). Piperazine (6 g, 40 mmol) was dissolved in toluene (85 mL) and stirred until completely dissolved. The reaction mixture was placed in an oil bath at 110°C and refluxed for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) during the reaction. After completion of the reaction, it was cooled to room temperature and dichloromethane (DCM) was added to disperse the reaction mixture. The insoluble material was removed by filtration and the filtrate was collected. The filtrate was concentrated and purified by silica gel column chromatography using an elution system containing 1% triethylamine in a gradient elution with petroleum ether and ethyl acetate (ratio tapered from 1:2 to 1:3). The target compound N-diphenylmethylpiperazine (S8, 7.6 g) was finally obtained in 74.2% yield.

References

[1] Patent: CN103524413, 2016, B. Location in patent: Paragraph 0060; 0061; 0062; 0066
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 4, p. 833 - 844
[3] European Journal of Medicinal Chemistry, 1987, vol. 22, p. 243 - 250
[4] Patent: US4355031, 1982, A

1-BENZHYDRYLPIPERAZINE Preparation Products And Raw materials

Raw materials

Piperazine Dilute hydrochloric acid Benzhydrol Chlorodiphenylmethane

Preparation Products

Meclozine Oxatomide Stugeron

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View Lastest Price from 1-BENZHYDRYLPIPERAZINE manufacturers

Xuchang Hengsheng Pharmaceutical Co., Ltd

Product: 1-(diphenylmethyl)-piperazin 841-77-0
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: ≥99.0%
Supply Ability: 10 Tons
Release date: 2024-08-07

Career Henan Chemical Co

Product: 1-BENZHYDRYLPIPERAZINE 841-77-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-24

841-77-0, 1-BENZHYDRYLPIPERAZINERelated Search:

1-(DiphenylMethyl)-4-[(1RS,3E)-4-phenyl-1-[(E)-2-phenylethenyl)-3-buten-1-yl]piperazine IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine IMp. C (EP): (4-(DiphenylMethyl)-1,1-bis[(E)-3-phenylprop-2-enyl]piperaziniuM Chloride (Z)-Cinnarizine Chlorodiphenylphosphine CHLORCYCLIZINE Cyclizine 1-BENZHYDRYLPIPERAZINE Hydroxyzine dihydrochloride CHLORCYCLIZINE HYDROCHLORIDE Flunarizine dihydrochloride Meclizine dihydrochloride 4,4'-Difluorobenzhydrylpiperazine 1-(4-Chlorobenzhydryl)piperazine Stugeron 1-(4,4'-DICHLOROBENZHYDRYL)PIPERAZINE Buterizine Piperazine

1-(diphenylmethyl)-piperazin

1-(Diphenylmethyl)piperazine,97%

AKOS BBS-00003601

AKOS NCG1-0108

TIMTEC-BB SBB003136

N-BENZHYDRYLPIPERAZINE

N-BENZYLHYDRYLPIPERAZINE

1-(DIPHENYLMETHYL)PIPERAZINE

1-BENZHYDRYLPIPERAZINE

1-BENZYHYDRYLPIPERAZINE

BENZHYDRYLPIPERAZINE

LABOTEST-BB LT00454383

1-Benzhydrylpiperazine 97%

1-Benzhydrylpiperazine ,99%

Cinnarizine Impurity 1(Cinnarizine EP Impurity A)

Piperazine, 1-(diphenylmethyl)-

4-(DiphenylMethyl)piperazine

NSC 35536

Cinnarizine EP IMpurity A

1-(DiphenylMethyl)piperazine SynonyMs Benzhydrylpiperazine

1-(Diphenylmethyl)piperazine >=98.0% (NT)

1-(Diphenylmethyl)piperazineone

4-benzhydrylpiperazine

Diphenylmethylpiperazine

N-(Diphenylmethyl)piperazine

norcyclizine

Cetirizine SM impurity 1 HCl

1-Benzhydrylpiperazine &gt

1-BENZHYDRYLPIPERAZINE ISO 9001：2015 REACH

Cinnarizine EP Impurity A 841-77-0

Nor-cyclizineQ: What is Nor-cyclizine Q: What is the CAS Number of Nor-cyclizine Q: What is the storage condition of Nor-cyclizine Q: What are the applications of Nor-cyclizine

1-BENZHYDRYLPIPERAZINEidazol-2-one

Benzhydrol piperzine

1-Benzhydrylpiperazine, 97%

841-77-0

C20H17N2

C17H20N2

AMINE

Building Blocks

Piperazines

Heterocyclic Building Blocks

Building Blocks

C16 to C29

Chemical Synthesis

Heterocyclic Building Blocks

Piperazines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Piperaizine

Piperazine derivates

Aromatics