ChemicalBook > CAS DataBase List > 1-BENZHYDRYLPIPERAZINE

1-BENZHYDRYLPIPERAZINE

Product Name: 1-BENZHYDRYLPIPERAZINE
CAS No.: 841-77-0
Chemical Name: 1-BENZHYDRYLPIPERAZINE
Synonyms: Diphenylmethylpiperazine;1-(DIPHENYLMETHYL)PIPERAZINE;NSC 35536;norcyclizine;AKOS NCG1-0108;AKOS BBS-00003601;TIMTEC-BB SBB003136;BENZHYDRYLPIPERAZINE;Benzhydrol piperzine;1-BENZHYDRYLPIPERAZINE
CBNumber: CB8117067
Molecular Formula: C17H20N2
Formula Weight: 252.35
MOL File: 841-77-0.mol

Less

1-BENZHYDRYLPIPERAZINE Property

Melting point:: 90-93 °C
Boiling point:: 185°C/2mmHg(lit.)
Density: 1.0546 (rough estimate)
vapor pressure: 0.001Pa at 20℃
refractive index: 1.5794 (estimate)
Flash point:: 115 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Methanol (Slightly)
pka: 9.05±0.10(Predicted)
form: Crystalline Powder
color: White to light yellow
Water Solubility: 0.45 g/L (20 ºC)
Sensitive: Air Sensitive
BRN: 222773
LogP: 0.6 at 20℃
CAS DataBase Reference: 841-77-0(CAS DataBase Reference)
NIST Chemistry Reference: Benzhydryl piperazine(841-77-0)

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 22
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TL6465000
F: 34
HazardClass: IRRITANT
HS Code: 29339900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B3760
Product name: 1-Benzhydrylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: B3760
Product name: 1-Benzhydrylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $251
Updated: 2025/07/31

TRC

Product number: B196950
Product name: 1-Benzhydrylpiperazine
Packaging: 50g
Price: $95
Updated: 2021/12/16

TRC

Product number: B196950
Product name: 1-Benzhydrylpiperazine
Packaging: 250g
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: J96137
Product name: 1-(Diphenylmethyl)piperazine
Packaging: 25g
Price: $15
Updated: 2021/12/16

Less

1-BENZHYDRYLPIPERAZINE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Cinnarizine (C465300) impurity.

Uses

1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.

Uses

1-Benzhydrylpiperazine is an intermediate used in drug synthesis

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006

General Description

1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones.

Flammability and Explosibility

Not classified

Synthesis

110-85-0

776-74-9

841-77-0

General procedure for the synthesis of N-diphenylmethylpiperazine from piperazine and diphenylmethyl bromide: accurately weigh diphenylmethyl bromide (10 g, 41 mmol), piperazine (9 g, 105 mmol), potassium carbonate (K2CO3, 14 g, 101 mmol) and sodium iodide (NaI). Piperazine (6 g, 40 mmol) was dissolved in toluene (85 mL) and stirred until completely dissolved. The reaction mixture was placed in an oil bath at 110°C and refluxed for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) during the reaction. After completion of the reaction, it was cooled to room temperature and dichloromethane (DCM) was added to disperse the reaction mixture. The insoluble material was removed by filtration and the filtrate was collected. The filtrate was concentrated and purified by silica gel column chromatography using an elution system containing 1% triethylamine in a gradient elution with petroleum ether and ethyl acetate (ratio tapered from 1:2 to 1:3). The target compound N-diphenylmethylpiperazine (S8, 7.6 g) was finally obtained in 74.2% yield.

References

[1] Patent: CN103524413, 2016, B. Location in patent: Paragraph 0060; 0061; 0062; 0066
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 4, p. 833 - 844
[3] European Journal of Medicinal Chemistry, 1987, vol. 22, p. 243 - 250
[4] Patent: US4355031, 1982, A

1-BENZHYDRYLPIPERAZINE Preparation Products And Raw materials

Raw materials

Piperazine Dilute hydrochloric acid Benzhydrol Chlorodiphenylmethane

Preparation Products

Meclozine Oxatomide Stugeron

Less

1-BENZHYDRYLPIPERAZINE Suppliers

Americas 1 Belgium 1 Canada 1 China 201 Europe 5 France 1 Germany 9 India 79 Japan 6 Russia 2 Slovakia 1 South Korea 1 Switzerland 4 The Netherlands 1 Ukraine 2 United Kingdom 14 United States 51 Global 380

Yangzhou Aoxin Chemical Co., Ltd

Tel: 0514-87754778 13901446058
Fax: +86-514-87752291
Email: sales@aochem.com
Country: China
ProdList: 73
Advantage: 66

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5158
Advantage: 50

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Simagchem Corp.

Tel: 86 592 2680277
Fax: 0086 592 2680237
Email: sale@simagchem.com
Country: China
ProdList: 430
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3930
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4942
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Shanghai QianJin Chemical Technology Co., Ltd

Tel: 021-20900665 17321230821
Fax: 021-20900665
Email: 2986274987@qq.com
Country: China
ProdList: 815
Advantage: 55

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Tonichem Pharmaceutical Technology Co., Ltd.

Tel: +86 (0752) 222-7171, +86 15815821171
Fax: +86 (0752) 222-6171
Country: China
ProdList: 1120
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Less

View Lastest Price from 1-BENZHYDRYLPIPERAZINE manufacturers

Xuchang Hengsheng Pharmaceutical Co., Ltd

Product: 1-(diphenylmethyl)-piperazin 841-77-0
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: ≥99.0%
Supply Ability: 10 Tons
Release date: 2024-08-07

Career Henan Chemical Co

Product: 1-BENZHYDRYLPIPERAZINE 841-77-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-24

841-77-0, 1-BENZHYDRYLPIPERAZINERelated Search:

1-(DiphenylMethyl)-4-[(1RS,3E)-4-phenyl-1-[(E)-2-phenylethenyl)-3-buten-1-yl]piperazine IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine IMp. C (EP): (4-(DiphenylMethyl)-1,1-bis[(E)-3-phenylprop-2-enyl]piperaziniuM Chloride (Z)-Cinnarizine Chlorodiphenylphosphine CHLORCYCLIZINE Cyclizine 1-BENZHYDRYLPIPERAZINE Hydroxyzine dihydrochloride CHLORCYCLIZINE HYDROCHLORIDE Flunarizine dihydrochloride Meclizine dihydrochloride 4,4'-Difluorobenzhydrylpiperazine 1-(4-Chlorobenzhydryl)piperazine Stugeron 1-(4,4'-DICHLOROBENZHYDRYL)PIPERAZINE Buterizine Piperazine

1-(diphenylmethyl)-piperazin

1-(Diphenylmethyl)piperazine,97%

AKOS BBS-00003601

AKOS NCG1-0108

TIMTEC-BB SBB003136

N-BENZHYDRYLPIPERAZINE

N-BENZYLHYDRYLPIPERAZINE

1-(DIPHENYLMETHYL)PIPERAZINE

1-BENZHYDRYLPIPERAZINE

1-BENZYHYDRYLPIPERAZINE

BENZHYDRYLPIPERAZINE

LABOTEST-BB LT00454383

1-Benzhydrylpiperazine 97%

1-Benzhydrylpiperazine ,99%

Cinnarizine Impurity 1(Cinnarizine EP Impurity A)

Piperazine, 1-(diphenylmethyl)-

4-(DiphenylMethyl)piperazine

NSC 35536

Cinnarizine EP IMpurity A

1-(DiphenylMethyl)piperazine SynonyMs Benzhydrylpiperazine

1-(Diphenylmethyl)piperazine >=98.0% (NT)

1-(Diphenylmethyl)piperazineone

4-benzhydrylpiperazine

Diphenylmethylpiperazine

N-(Diphenylmethyl)piperazine

norcyclizine

Cetirizine SM impurity 1 HCl

1-Benzhydrylpiperazine &gt

1-BENZHYDRYLPIPERAZINE ISO 9001：2015 REACH

Cinnarizine EP Impurity A 841-77-0

Nor-cyclizineQ: What is Nor-cyclizine Q: What is the CAS Number of Nor-cyclizine Q: What is the storage condition of Nor-cyclizine Q: What are the applications of Nor-cyclizine

1-BENZHYDRYLPIPERAZINEidazol-2-one

Benzhydrol piperzine

1-Benzhydrylpiperazine, 97%

841-77-0

C20H17N2

C17H20N2

AMINE

Building Blocks

Piperazines

Heterocyclic Building Blocks

Building Blocks

C16 to C29

Chemical Synthesis

Heterocyclic Building Blocks

Piperazines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Piperaizine

Piperazine derivates

Aromatics