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Atipamezole hydrochloride

Product Name
Atipamezole hydrochloride
CAS No.
104075-48-1
Chemical Name
Atipamezole hydrochloride
Synonyms
Antisedan;Unii-2W4279571x;Atipamezole HCL;MPV1248 hydrochloride;MPV-1248 hydrochloride;MPV 1248 hydrochloride;Atipamezole hydrochloride;Atipamezole HCl (MPV-1248);Atipamezole hydrochloride, >=99%;4-(2-ethylindan-2-yl)-1H-imidazole
CBNumber
CB81210097
Molecular Formula
C14H16N2.HCl
Formula Weight
248.75
MOL File
104075-48-1.mol
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Atipamezole hydrochloride Property

Melting point:
211-215°
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Merck 
14,861
InChI
InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H
InChIKey
PCCVCJAQMHDWJY-UHFFFAOYSA-N
SMILES
C1(CC)(CC2=C(C=CC=C2)C1)C1=CNC=N1.Cl
CAS DataBase Reference
104075-48-1(CAS DataBase Reference)
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Safety

RTECS 
NI6139000
HS Code 
2933.29.2000
Toxicity
LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2956
Product name
Atipamezole Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25mg
Price
$299
Updated
2024/03/01
TCI Chemical
Product number
A2956
Product name
Atipamezole Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$596
Updated
2024/03/01
Alfa Aesar
Product number
H37332
Product name
Atipamezole (hydrochloride)
Packaging
1g
Price
$406
Updated
2021/12/16
Alfa Aesar
Product number
H37332
Product name
Atipamezole (hydrochloride)
Packaging
250mg
Price
$123
Updated
2021/12/16
Cayman Chemical
Product number
9001181
Product name
Atipamezole (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$72
Updated
2024/03/01
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Atipamezole hydrochloride Chemical Properties,Usage,Production

Uses

Atipamezole Hydrochloride, is the a synthetic α2-adrenergic antagonist, usually used to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been shown to be used as possible anti-Parkinsonian drug in humans.

Biological Activity

Selective α 2 -adrenergic receptor antagonist (K i values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α 2A , α 2B , α 2C , α 1A and α 1B receptors respectively). Brain penetrant.

Side effects

A transient hypotensive effect has been observed during the first 10 minutes post-injection of atipamezole hydrochloride. In rare cases, hyperactivity, tachycardia, salivation, atypical vocalization, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination, and defecation may occur. In very rare cases, recurrence of sedation may occur, or the recovery time may not be shortened after administration of atipamezole. In cats, when using low doses to reverse the effects of medetomidine or dexmedetomidine partially, the possibility of hypothermia (even when aroused from sedation) should be guarded against.

Veterinary Drugs and Treatments

Atipamezole is labeled for use as a reversal agent for medetomidine and dexmedetomidine. It potentially could be useful for reversal of other alpha2-adrenergic agonists as well (e.g., amitraz, xylazine, clonidine, tizanidine, brimonidine).

storage

Desiccate at RT

Atipamezole hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Atipamezole hydrochloride Suppliers

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View Lastest Price from Atipamezole hydrochloride manufacturers

airuikechemical co., ltd.
Product
atipamezole hcl 104075-48-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Atipamezole hydrochloride 104075-48-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
10kg/month
Release date
2021-05-27
Hangzhou ICH Biofarm Co., Ltd
Product
Atipamezole hydrochloride 104075-48-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99% HPLC
Supply Ability
100kg
Release date
2023-07-05

104075-48-1, Atipamezole hydrochlorideRelated Search:

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  • 104075-48-1
  • API