ChemicalBook > CAS DataBase List > Ethyl 2-bromothiazole-4-carboxylate

Ethyl 2-bromothiazole-4-carboxylate

Product Name
Ethyl 2-bromothiazole-4-carboxylate
CAS No.
100367-77-9
Chemical Name
Ethyl 2-bromothiazole-4-carboxylate
Synonyms
ETHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE;ethyl 2-bromo-4-thiazolecarboxylate;ethyl 2-broMo-thiazol-4-carboxylate;Ethyl2-Bromothiazole-4-carboxylate>Ethyl2-bromothiazole-4-carboxylate,97%;2-Bromo-4-(ethoxycarbonyl)-1,3-thiazole;Ethyl 2-bromothiazole-4-carboxylate 96%;Ethyl 2-Bromothiazole-4-Carboxylate SKY;ethyl 2-bromo-1,3-thiazole-4-carboxylate;2-bromo-4-thiazolecarboxylic acid ethyl ester
CBNumber
CB8173805
Molecular Formula
C6H6BrNO2S
Formula Weight
236.09
MOL File
100367-77-9.mol
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Ethyl 2-bromothiazole-4-carboxylate Property

Melting point:
67-71 °C
Boiling point:
154°C/13mmHg(lit.)
Density 
1.654±0.06 g/cm3(Predicted)
Flash point:
>110℃
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
-1.50±0.10(Predicted)
color 
White to Almost white
Sensitive 
Moisture & Light Sensitive
InChI
InChI=1S/C6H6BrNO2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3
InChIKey
CNHISCQPKKGDPO-UHFFFAOYSA-N
SMILES
S1C=C(C(OCC)=O)N=C1Br
CAS DataBase Reference
100367-77-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-24/25
WGK Germany 
2
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT
HS Code 
29341000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
708429
Product name
Ethyl 2-bromothiazole-4-carboxylate
Purity
96%
Packaging
1g
Price
$95.5
Updated
2023/01/07
TCI Chemical
Product number
E0900
Product name
Ethyl 2-Bromothiazole-4-carboxylate
Purity
>95.0%(GC)
Packaging
1g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
E0900
Product name
Ethyl 2-Bromothiazole-4-carboxylate
Purity
>95.0%(GC)
Packaging
5g
Price
$93
Updated
2025/07/31
TCI Chemical
Product number
E0900
Product name
Ethyl 2-Bromothiazole-4-carboxylate
Purity
>95.0%(GC)
Packaging
25g
Price
$265
Updated
2025/07/31
TRC
Product number
E900913
Product name
Ethyl 2-bromothiazole-4-carboxylate
Packaging
250mg
Price
$55
Updated
2021/12/16
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Ethyl 2-bromothiazole-4-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Ethyl 2-bromothiazole-4-carboxylate is an essential organic reagent that can be used as a building block for the synthesis of many organic compounds, such as 4-Thiazolecarboxylic acid, Ethyl thiazole-4-carboxylate， 2-Bromothiazole-4-carboxylic acid and so on.

Synthesis

5398-36-7

100367-77-9

Ethyl 2-aminothiazole-4-carboxylate (100 g, 581 mmol) and copper(II) bromide (195 g, 871 mmol) were dissolved in acetonitrile (1000 ml) at 0 °C. Subsequently, tert-butyl nitrite (104 ml, 871 mmol) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and stirred continuously for 12 hours. After completion of the reaction, the reaction mixture was diluted with a mixture of ethyl acetate (1000 ml) and water (3000 ml) and the pH was adjusted to 2 with 1 N hydrochloric acid.The organic and aqueous layers were separated, and the aqueous layer was extracted three times with ethyl acetate (500 ml). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by recrystallization from hexane to give pure ethyl 2-bromothiazole-4-carboxylate (115 g, 84% yield). The product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 8.52 (s, 1H), 4.29 (q, J=7.1 Hz, 2H), 1.29 (t, J=7.1 Hz, 3H). Mass spectral analysis showed m/z 235.90 [M+1].

References

[1] Russian Journal of General Chemistry, 2017, vol. 87, # 12, p. 2766 - 2775
[2] Zh. Obshch. Khim., 2017, vol. 87, # 12, p. 1947 - 1956,10
[3] Patent: WO2018/193387, 2018, A1. Location in patent: Page/Page column 92
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 2, p. 533 - 536
[5] Patent: US6468979, 2002, B1

Ethyl 2-bromothiazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl 2-bromothiazole-4-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
PNP Biotech Co. Ltd
Product
Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-06-26
Career Henan Chemical Co
Product
Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10 tons/month
Release date
2020-01-07

100367-77-9, Ethyl 2-bromothiazole-4-carboxylateRelated Search:

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