TRICHOSTATIN A
- Product Name
- TRICHOSTATIN A
- CAS No.
- 58880-19-6
- Chemical Name
- TRICHOSTATIN A
- Synonyms
- TSA;A 300I;CS-210;CS-2704;richostatinA;trichostatin;TRICHOSTATIN A;(R)-Trichostatin A;(+)-Trichostatin A;Trichostatin A (TSA)
- CBNumber
- CB8257301
- Molecular Formula
- C17H22N2O3
- Formula Weight
- 302.37
- MOL File
- 58880-19-6.mol
TRICHOSTATIN A Property
- Melting point:
- 140-143℃
- alpha
- D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
- Density
- 1.139
- refractive index
- 136 ° (C=0.3, MeOH)
- storage temp.
- -20°C
- solubility
- ethanol: 1 mg/mL
- form
- Off-white lyophilized solid
- pka
- 8.93±0.23(Predicted)
- color
- Tan
- Merck
- 14,9649
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- ZWGICMNKJBUOHG-RCXLNATQSA-N
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38-43
- Safety Statements
- 26-36
- RIDADR
- NA 1993 / PGIII
- WGK Germany
- 3
- RTECS
- MI5215000
- HS Code
- 29280000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T1952
- Product name
- Trichostatin A, Ready Made Solution
- Purity
- 5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp.
- Packaging
- 200μL
- Price
- $87.6
- Updated
- 2024/03/01
- Product number
- 647925
- Product name
- Trichostatin A
- Packaging
- 1mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- T2477
- Product name
- Trichostatin A
- Purity
- >98.0%(HPLC)
- Packaging
- 10mg
- Price
- $551
- Updated
- 2024/03/01
- Product number
- T2477
- Product name
- Trichostatin A
- Purity
- >98.0%(HPLC)
- Packaging
- 50mg
- Price
- $1901
- Updated
- 2024/03/01
- Product number
- 89730
- Product name
- Trichostatin A
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $56
- Updated
- 2024/03/01
TRICHOSTATIN A Chemical Properties,Usage,Production
Description
Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.
Chemical Properties
Solid
Uses
Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity
Uses
Trichostatin A, ready-made solution has been used:
- as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
- to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
- to treat cells for the HDAC inhibition experiments
Uses
Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.
Definition
ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid.
General Description
Trichostatin A is a compound of primary hydroxamic acid.
Biological Activity
Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.
Biochem/physiol Actions
Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.
storage
-20°C (desiccate)
References
1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174 2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119 3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531
TRICHOSTATIN A Preparation Products And Raw materials
Raw materials
Preparation Products
TRICHOSTATIN A Suppliers
- Tel
- --
- Fax
- --
- sales21@chemicalland21.com
- Country
- South Korea
- ProdList
- 6303
- Advantage
- 74
View Lastest Price from TRICHOSTATIN A manufacturers
- Product
- Trichostatin A 58880-19-6
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Metric Ton/Month
- Release date
- 2024-01-17
- Product
- trichostatin A 58880-19-6
- Price
- US $0.00/KG
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 1 ton
- Release date
- 2019-10-23
- Product
- TRICHOSTATIN A 58880-19-6
- Price
- US $11.00/Kg/Bag
- Min. Order
- 25Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-11-02