TRICHOSTATIN A

Product Name: TRICHOSTATIN A
CAS No.: 58880-19-6
Chemical Name: TRICHOSTATIN A
Synonyms: TSA;A 300I;CS-210;CS-2704;richostatinA;trichostatin;TRICHOSTATIN A;(R)-Trichostatin A;(+)-Trichostatin A;Trichostatin A (TSA)
CBNumber: CB8257301
Molecular Formula: C17H22N2O3
Formula Weight: 302.37
MOL File: 58880-19-6.mol

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TRICHOSTATIN A Property

Melting point:: 140-143℃
alpha: D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
Density: 1.139
refractive index: 136 ° (C=0.3, MeOH)
storage temp.: -20°C
solubility: ethanol: 1 mg/mL
form: Off-white lyophilized solid
pka: 8.93±0.23(Predicted)
color: Tan
Merck: 14,9649
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey: ZWGICMNKJBUOHG-RCXLNATQSA-N

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-43
Safety Statements: 26-36
RIDADR: NA 1993 / PGIII
WGK Germany: 3
RTECS: MI5215000
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T1952
Product name: Trichostatin A, Ready Made Solution
Purity: 5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp.
Packaging: 200μL
Price: $87.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 647925
Product name: Trichostatin A
Packaging: 1mg
Price: $289
Updated: 2024/03/01

TCI Chemical

Product number: T2477
Product name: Trichostatin A
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $551
Updated: 2024/03/01

TCI Chemical

Product number: T2477
Product name: Trichostatin A
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $1901
Updated: 2024/03/01

Cayman Chemical

Product number: 89730
Product name: Trichostatin A
Purity: ≥98%
Packaging: 500μg
Price: $56
Updated: 2024/03/01

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TRICHOSTATIN A Chemical Properties,Usage,Production

Description

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.

Chemical Properties

Solid

Uses

Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity

Uses

Trichostatin A, ready-made solution has been used:

as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
to treat cells for the HDAC inhibition experiments

Uses

Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.

Definition

ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid.

General Description

Trichostatin A is a compound of primary hydroxamic acid.

Biological Activity

Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

Biochem/physiol Actions

Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.

storage

-20°C (desiccate)

References

1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174 2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119 3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531

TRICHOSTATIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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TRICHOSTATIN A Suppliers

Canada 1 China 170 France 1 Germany 5 India 4 Japan 2 South Korea 1 Switzerland 2 United Kingdom 9 United States 34 Global 229

VDM Biochemicals

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View Lastest Price from TRICHOSTATIN A manufacturers

Wuhan Xinhao Biotechnology Co., Ltd

Product: Trichostatin A 58880-19-6
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-01-17

Hebei shuoxi biotechnology co. LTD

Product: trichostatin A 58880-19-6
Price: US $0.00/KG
Min. Order: 1g
Purity: 99.9%
Supply Ability: 1 ton
Release date: 2019-10-23

Longyan Tianhua Biological Technology Co., Ltd

Product: TRICHOSTATIN A 58880-19-6
Price: US $11.00/Kg/Bag
Min. Order: 25Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-11-02

58880-19-6, TRICHOSTATIN ARelated Search:

Tubacin HC TOXIN M344 Parthenolide Panobinostat JNJ-26481585 Vorinostat MG-132 Entinostat LY 294002 HYDROCHLORIDE TRICHOSTATIN A SORBOHYDROXAMIC ACID INHIBITOR-1 OF TRICHOSTATIN A,INHIBITOR OF TRICHOSTATIN A 1 TRICHOSTATIN C TRICHOSTATIN B TRICHOSTATIN A (DRY ICE) TRICHOSTATIN, TRICHOSPDRIELLA SP. trichostatin D

7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide

7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE

4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID

4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID

Trichostatin A from Streptomyces platensis

[r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE

TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

TSA

TRICHOSTATIN A

TRICHOSTATIN A, STREPTOMYCES SPECIES

Trichostatin A, Streptomyces sp.

2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-

TRICHOSTATIN A FROM STREPTOMYCES SP

(2E,4E,6R)-4,6-Dimethyl-7-[4-(dimethylamino)phenyl]-7-oxo-2,4-heptadienehydroximic acid

(2E,4E,6R)-4,6-Dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienehydroximic acid

Trichostatin A,TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

(R)-Trichostatin A

Trichostatin A (TSA)

A 300I

(R,2E,4E)-6-(4-(dimethylamino)benzoyl)-N-hydroxy-4-methylhepta-2,4-dienamide

Trichostatin A, Ready Made Solution

Trichostatin A Vetec(TM) reagent grade, from Streptomyces sp., >=98%

(2E,4E,6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE

Trichostatin A, 98%, from Streptomyces sp.

CS-2704

CS-210

isolated from species of the bacterial genus Streptomyces.

richostatinA

TRICHOSTATIN A USP/EP/BP

trichostatin

(R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

Histone deacetylases,inhibit,Inhibitor,HDAC,Trichostatin A

Trichostatin A solution(10mM/L)

(+)-Trichostatin A

Trichostatin A (R-isomer)

58880-19-6

5880-19-6

Gene Regulation and Expression

DNA-RNA Transcription Regulators

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Inhibitors

antibiotic

API

Anti Cancer Research

Inhibitor