ChemicalBook > CAS DataBase List > FLI-06
FLI-06
- Product Name
- FLI-06
- CAS No.
- 313967-18-9
- Chemical Name
- FLI-06
- Synonyms
- I-06;FLI-06;CS-1434;FLI-06 |FLI06;inhibit,Inhibitor,Notch,FLI-06,FLI06;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor;Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester;3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06
- CBNumber
- CB82682028
- Molecular Formula
- C25H30N2O5
- Formula Weight
- 438.52
- MOL File
- 313967-18-9.mol
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FLI-06 Property
- Melting point:
- 199-202oC
- Boiling point:
- 597.5±50.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- pka
- 0.78±0.70(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
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Safety
- RIDADR
- 3077
- WGK Germany
- 3
- HS Code
- 29339900
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0975
- Product name
- FLI-06
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0975
- Product name
- FLI-06
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $190.4
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21272
- Product name
- FLI-06
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21272
- Product name
- FLI-06
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $146
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21272
- Product name
- FLI-06
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $317
- Updated
- 2024/03/01
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FLI-06 Chemical Properties,Usage,Production
Description
FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1
Uses
FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.
References
1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731
FLI-06 Preparation Products And Raw materials
Raw materials
Preparation Products
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FLI-06 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
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View Lastest Price from FLI-06 manufacturers
Career Henan Chemical Co
- Product
- 3-?Quinolinecarboxylic acid, 1,?4,?5,?6,?7,?8-?hexahydro-?2,?7,?7-?trimethyl-?4-?(4-?nitrophenyl)?-?5-?oxo-?, cyclohexyl ester 313967-18-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23
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