ChemicalBook > CAS DataBase List > FLI-06

FLI-06

Product Name
FLI-06
CAS No.
313967-18-9
Chemical Name
FLI-06
Synonyms
I-06;FLI-06;CS-1434;FLI-06 |FLI06;FLI-06, 10 mM in DMSO;FLI-06, Notch signaling inhibitor;inhibit,Inhibitor,Notch,FLI-06,FLI06;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor;Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester
CBNumber
CB82682028
Molecular Formula
C25H30N2O5
Formula Weight
438.52
MOL File
313967-18-9.mol
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FLI-06 Property

Melting point:
199-202oC
Boiling point:
597.5±50.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
pka
0.78±0.70(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
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Safety

RIDADR 
3077
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0975
Product name
FLI-06
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0975
Product name
FLI-06
Purity
≥98% (HPLC)
Packaging
25mg
Price
$190.4
Updated
2024/03/01
Cayman Chemical
Product number
21272
Product name
FLI-06
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
21272
Product name
FLI-06
Purity
≥98%
Packaging
10mg
Price
$146
Updated
2024/03/01
Cayman Chemical
Product number
21272
Product name
FLI-06
Purity
≥98%
Packaging
25mg
Price
$317
Updated
2024/03/01
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FLI-06 Chemical Properties,Usage,Production

Description

FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1

Uses

FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.

References

1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731

FLI-06 Preparation Products And Raw materials

Raw materials

Preparation Products

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FLI-06 Suppliers

China 81 India 2 United Kingdom 2 United States 19 Global 104
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
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+1 (866) 333-9607
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info@adooq.com
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United States
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Target molecule Corp.
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857-239-0968
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857-239-8801
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service1@targetmol.com
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United States
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60
Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
Email
sales@invivochem.cn
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United States
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Cckinase, Inc.
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+1 (732)236-3202
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sales@cckinase.com
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United States
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BOC Sciences
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inquiry@bocsci.com
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Aladdin Scientific
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sales@aladdinsci.com
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States Biological
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Focus Biomolecules
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Cayman Chemical Company
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United States Biological
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Riedel-de Haen AG
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Selleck Chemicals LLC
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View Lastest Price from FLI-06 manufacturers

Career Henan Chemical Co
Product
3-?Quinolinecarboxylic acid, 1,?4,?5,?6,?7,?8-?hexahydro-?2,?7,?7-?trimethyl-?4-?(4-?nitrophenyl)?-?5-?oxo-?, cyclohexyl ester 313967-18-9
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

313967-18-9, FLI-06Related Search:

Fatostatin A 2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol SGC-GAK-1 KPT-330 xav-939 Semagacestat LY411575 RO4929097 CHIR-99021 DIBENZAZEPINE

  • FLI-06
  • 1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester
  • 1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06
  • 3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER
  • FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor
  • FLI-06 |FLI06
  • Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
  • CS-1434
  • I-06
  • inhibit,Inhibitor,Notch,FLI-06,FLI06
  • FLI-06, Notch signaling inhibitor
  • FLI-06, 10 mM in DMSO
  • 313967-18-9
  • Inhibitors