ChemicalBook > CAS DataBase List > ML224

ML224

Product Name
ML224
CAS No.
1338824-21-7
Chemical Name
ML224
Synonyms
ML224;ANTAG3);CS-1585;NCGC00242364;ML224,ML-224;ML-224(ANTAG3);ML224(NCGC00242364;ML224, 10 mM in DMSO;NCGC00242364;ANTAG3;ML-224;ML 224;N-{4-[(5-{3-[(furan-2-yl)methyl]-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl}-2-methoxyphenyl)methoxy]-3,5-dimethylphenyl}acetamide
CBNumber
CB82735528
Molecular Formula
C31H31N3O5
Formula Weight
525.59
MOL File
1338824-21-7.mol
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ML224 Property

Boiling point:
752.3±60.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (190.26 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
pka
14.52±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3824
Product name
ML224
Purity
98.72%
Packaging
5mg
Price
$150
Updated
2021/12/16
ApexBio Technology
Product number
B4914
Product name
ML224
Packaging
5mg
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-3824
Product name
ML224
Purity
98.72%
Packaging
10mg
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-3824
Product name
ML224
Purity
98.72%
Packaging
50mg
Price
$750
Updated
2021/12/16
ApexBio Technology
Product number
B4914
Product name
ML224
Packaging
50mg
Price
$1100
Updated
2021/12/16
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ML224 Chemical Properties,Usage,Production

Uses

ML224 (NCGC00242364) is a selective TSHR antagonist with an IC50 value of 2.1 μM. ML224 can be used in the study of Graves' disease and other thyroid disorders.

Definition

ChEBI: N-[4-[[5-[3-(2-furanylmethyl)-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]-3,5-dimethylphenyl]acetamide is a member of quinazolines.

in vivo

ANTAG3 (2 mg/mice; i.p. via osmotic pump; single daily for 3 days) lowers serum FT4 levels and thyroidal mRNAs for TPO and NIS in mice continuously stimulated by TRH[1].

Animal Model:Female BALB/c mice (8 to 13-week-old; ~18.7 g)[1].
Dosage:2 mg/mice
Administration:Intraperitoneal injection via osmotic pump; single daily for 3 days
Result:Lowered the levels of FT4 by 44%, and the levels of TPO and NIS mRNAs by 75% and 83%, respectively.

IC 50

TSHR: 2.1 μM (IC50); LHR: ＞30 μM (IC50); FSHR: ＞30 μM (IC50)

References

[1] Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4. DOI:10.1210/en.2013-1835

ML224 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML224 Suppliers

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1338824-21-7, ML224Related Search:

CID-49830258 ML365 ML-7 HYDROCHLORIDE 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a] ML281 ML234 ML 141 M348 ML-098 ML277 ML329 ML364 ML-323 ML264 ML216

  • ML224
  • ANTAG3)
  • ML224(NCGC00242364
  • CS-1585
  • NCGC00242364
  • NCGC00242364;ANTAG3;ML-224;ML 224
  • ML-224(ANTAG3)
  • Acetamide, N-[4-[[5-[3-(2-furanylmethyl)-1,2,3,4-tetrahydro-4-oxo-2-quinazolinyl]-2-methoxyphenyl]methoxy]-3,5-dimethylphenyl]-
  • ML224,ML-224
  • N-{4-[(5-{3-[(furan-2-yl)methyl]-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl}-2-methoxyphenyl)methoxy]-3,5-dimethylphenyl}acetamide
  • ML224, 10 mM in DMSO
  • 1338824-21-7