ChemicalBook > CAS DataBase List > 2'-O-MOE-A(Bz)-3'-phosphoramidite

2'-O-MOE-A(Bz)-3'-phosphoramidite

Product Name
2'-O-MOE-A(Bz)-3'-phosphoramidite
CAS No.
251647-53-7
Chemical Name
2'-O-MOE-A(Bz)-3'-phosphoramidite
Synonyms
DMT-2'-O-MOE-A(Bz)-CE;2’-MOE-dA(Bz) Amidite;2’-MOE-dA(Bz) Amidite;2'-MOE-Bz-A Phosphoramidite;N6-Bz-5'-O-DMT-2'-O-MOE-A-CE;2'-O-MOE-Bz-A Phosphoramidite;2'-MOE-N-Bz Adenosine Amidite;2'-MOE-N-Bz Adenosine Amidite;2'-MOE-Bz-A CE Phosphoramidite;2'-MOE-Bz-A CE Phosphoramidite
CBNumber
CB83051689
Molecular Formula
C50H58N7O9P
Formula Weight
932.01
MOL File
251647-53-7.mol
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2'-O-MOE-A(Bz)-3'-phosphoramidite Property

pka
7.87±0.43(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1/C50H58N7O9P/c1-34(2)57(35(3)4)67(64-28-14-27-51)66-44-42(31-63-50(37-17-12-9-13-18-37,38-19-23-40(60-6)24-20-38)39-21-25-41(61-7)26-22-39)65-49(45(44)62-30-29-59-5)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-15-10-8-11-16-36/h8-13,15-26,32-35,42,44-45,49H,14,28-31H2,1-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,67?/s3
InChIKey
VPBYBQBHLYRLHG-VCCSSPGHNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,52,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B207938
Product name
N6-Benzoyl-5''-O-DMT-2''-O-(2-methoxyethyl)adenosine3''-CEPhosphoramidite
Packaging
50mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB59569
Product name
N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
Packaging
250mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB59569
Product name
N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
Packaging
500mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB59569
Product name
N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
Packaging
1g
Price
$275
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB59569
Product name
N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
Packaging
2g
Price
$500
Updated
2021/12/16
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2'-O-MOE-A(Bz)-3'-phosphoramidite Chemical Properties,Usage,Production

Description

2'-O-MOE-A(Bz)-3'-phosphoramidite, also known as DMT-2'-O-MOE-rA(Bz) phosphoramidite, inserts 2'-O-methoxyethyl-modified adenosine into oligonucleotide phosphoramidites for antisense RNA. Its 2'-MOE backbone bolsters duplex stability, nuclease resistance, and has low toxicity, contributing to effective, safe genetic manipulation. It is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).

Chemical Properties

The IUPAC name of 2'-O-MOE-A(Bz)-3'-phosphoramidite is (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. It is white to off-white powder.

Uses

N6-Benzoyl-5''-O-DMT-2''-O-(2-methoxyethyl)adenosine 3''-CE phosphoramidite (CAS# 251647-53-7) is used diagnostically in the screening of insulin-like growth factor-I (IGF-I) and growth hormone receptor (GHR) oligonucleotidic modulators.

2'-O-MOE-A(Bz)-3'-phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-MOE-A(Bz)-3'-phosphoramidite Suppliers

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View Lastest Price from 2'-O-MOE-A(Bz)-3'-phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
N6-Bz-5'-O-DMT-2'-O-MOE-A-CE 251647-53-7
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
SHANGHAI NOVRIBO BIOTECH
Product
2'-MOE-Bz-A CE Phosphoramidite 251647-53-7
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-20

251647-53-7, 2'-O-MOE-A(Bz)-3'-phosphoramiditeRelated Search:

2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-(2-Methoxyethyl)-5-methyluridine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine 2'-O-(2-Methoxyethyl)cytidine 2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite 2'-O-(2-Methoxyethyl)guanosine

  • 2'-O-MOE-A(Bz)-3'-phosphoramidite
  • N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)adenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
  • 2'-O-MOE-A(Bz)-CE Phosphoramidite
  • ADENOSINE, N-BENZOYL-5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-O-(2-METHOXYETHYL)-, 3'-[2-CYANOETHYL BIS(1-METHYLETHYL)PHOSPHORAMIDITE] (9CI)
  • 2'-O-MOE-Bz-A Phosphoramidite
  • 5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-O-ME-A(BZ) PHOSPHORAMIDITE
  • DMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite
  • N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine-3'-cyanoethyl Phosphoramidite
  • Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • N6-Benzoyl-5’-O-(4,4’-dimethoxy-trityl)-2’-O-(2-methoxyethyl)adeno sine-3’-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphorramidite
  • 2'-O-MOE-rA(Bz) Phosphoramidite)
  • 5'-O-DMT-N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
  • Adenosine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-N6-benzoyl-adenosine -3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5'-DMTr-2'-MOE-N6-Bz-3'-CEP-Adenosine
  • 5'-DMTr-2'-MOE-N6Bz-3'-O-CEP-ADENOSINE
  • DMT-2′O-MOE-rA(bz) Phosphoramidite
  • 2’-O-MOE-A(Bz)-3’-phospho ramidite, N6-Benzoyl-5’-O-(4,4’-dimethoxy-trityl)-2’-O-(2-methoxyethyl)adeno sine-3’-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphorramidite
  • N6-Bz-5’-O-DMTr-2’-O-(2-methoxyethyl)-adenosine-3’-CED-phosphoramidite
  • N6-Bz-5'-O-DMT-2'-O-MOE-A-CE
  • 5'-O-DMT-2'-O-MOE-A(Bz)-CE Phosphoramidite
  • 2'-MOE-Bz-A CE Phosphoramidite
  • 5'-O-DMT-2'-O-MOE-N6-Benzoyl- Adenosine -3’-Cyanoethyl Phosphoramidite
  • 2'-MOE-N-Bz Adenosine Amidite
  • DMT-2'-O-MOE-A(Bz)-CE
  • DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite
  • 2’-MOE-dA(Bz) Amidite
  • N6-Benzoyl-2-o-methyladenosine 3-ce phosphoramidite
  • N6-Benzoyl-5’-O-(4, 4’-dimethoxytrityl)-2’-O-(2-methoxyethyl)adenosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-ODMT-2'-OMOE-N-Bz Adenosine-3'-OCEPA
  • 2'-O-MOE-A(Bz)-3'-phosphoramidite
  • DMT-2'-O-MOE-A(Bz)-CE Phosphoramidite
  • 2'-MOE-Bz-A CE Phosphoramidite
  • 2'-O-MOE-A(Bz)-CE-Phosphoramidite
  • 2’-MOE-dA(Bz) Amidite
  • N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine-3'-cyanoethyl Phosphoramidite
  • (2R,3R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
  • N6-Bz-2'-O-MOE-5'-O-DMT-A-3'-CE-Phosphoramidite
  • 2'-O-MOE-rA(Bz)Phosphoramidite
  • 5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-O-ME-A(BZ) PHOSPHORAMIDITE
  • DMT-2'-O-MOE-rA(Bz) phosphoramidite
  • N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-O-MOE-N6-Benzoyl- Adenosine -3’-Cyanoethyl Phosphoramidite
  • 2'-MOE-N-Bz Adenosine Amidite
  • 2'-MOE-Bz-A Phosphoramidite
  • 251647-53-7
  • C50H58N7O9P
  • Amidite