ChemicalBook > CAS DataBase List > 4-Hydroxy-3,5-dimethoxycinnamic acid

4-Hydroxy-3,5-dimethoxycinnamic acid

Product Name
4-Hydroxy-3,5-dimethoxycinnamic acid
CAS No.
530-59-6
Chemical Name
4-Hydroxy-3,5-dimethoxycinnamic acid
Synonyms
SINAPIC ACID;SINAPINIC ACID;3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID;(E)-3-(4-hydroxy-3,5-diMethoxyphenyl)acrylic acid;NSC 59261;Dimethoxy MS;Synapoic acid;Synapitic Acid;SIMPLEXOLIN(RG);rans-sinapicaci
CBNumber
CB8328696
Molecular Formula
C11H12O5
Formula Weight
224.21
MOL File
530-59-6.mol
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4-Hydroxy-3,5-dimethoxycinnamic acid Property

Melting point:
~202 °C
Boiling point:
285.61°C (rough estimate)
Density 
1.1478 (rough estimate)
refractive index 
1.4720 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: slightly soluble
form 
powder
pka
4.53±0.10(Predicted)
color 
white
Odor
at 100.00?%. odorless
Water Solubility 
insoluble
BRN 
2130006
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.
LogP
0.997 (est)
CAS DataBase Reference
530-59-6(CAS DataBase Reference)
NIST Chemistry Reference
Cinnamic acid, 4-hydroxy-3,5-dimethoxy-(530-59-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
85429
Product name
Sinapic acid
Purity
matrix substance for MALDI-MS, ≥99.0% (T)
Packaging
1g
Price
$91
Updated
2024/03/01
Sigma-Aldrich
Product number
49508
Product name
Sinapic acid
Purity
matrix substance for MALDI-MS, ≥99.5%, Ultra pure
Packaging
10x10mg
Price
$332
Updated
2024/03/01
TCI Chemical
Product number
D1765
Product name
3,5-Dimethoxy-4-hydroxycinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$57
Updated
2024/03/01
TCI Chemical
Product number
D1765
Product name
3,5-Dimethoxy-4-hydroxycinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$166
Updated
2024/03/01
Alfa Aesar
Product number
A15676
Product name
4-Hydroxy-3,5-dimethoxycinnamic acid, 98%
Packaging
1g
Price
$30.65
Updated
2024/03/01
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4-Hydroxy-3,5-dimethoxycinnamic acid Chemical Properties,Usage,Production

Chemical Properties

yellow-brown crystalline powder

Uses

4-Hydroxy-3,5-dimethoxycinnamic acid is a commonly used matrix in MALDI mass spectrometry. It is a useful matrix for a wide variety of peptides and proteins. It serves well as a matrix for MALDI due to its ability to absorb laser radiation and to also donate protons (H+) to the analyte of interest.

Uses

Sinapic acid was suitable as phenolic standard for HPLC analysis in determination of Sinapic acid derivatives in Canola extracts. 10 g/L of sinapinic acid with solvent was suitable as matrix for ultraviolet laser desorption mass spectrometric determination of proteins. It was also suitable to use as matrix for MALDI-TOFMS and MALDI-ion mobility-TOFMS to determine phospholipids in tissue.

Definition

ChEBI: A monohydroxycinnamic acid that is cinnamic acid in which the phenyl hydrogens at positions 3, 4, and 5 are replaced by methoxy, hydroxy, and methoxy groups, respectively.

General Description

Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.

Biochem/physiol Actions

On removal of amino group from phenylalanine, catalysing with enzyme phenylalanine ammonia-lyase forms cinnamic acid. The precursor of hydroxycinnamates is produced after hydroxylation of benzene ring. One of the precursors produced is sinapic acid. Sinapic acid exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anti-anxiety activity. Sinapine (sinapoyl choline) has been acknowledged as an acetylcholinesterase inhibitor, making it therapeutically applicable in treatment of various diseases. 4-Vinylsyringol (a decarboxylation product of sinapic acid) is a potent antimutagenic and antioxidative agent, involved in suppressing the induction of inflammatory cytokines and carcinogenesis. Owing to their anti-oxidative activity, these compounds have been considered to be potentially employed in the pharmaceutical industry, cosmetics and food processing.

Purification Methods

Crystallise it from water. [Beilstein 10 H 508, 10 IV 2104.]

4-Hydroxy-3,5-dimethoxycinnamic acid Preparation Products And Raw materials

Raw materials

Piperidine 3,4,5-Trimethoxybenzaldehyde Ethyl hydrogen malonate Hydrochloric acid Pyridine

Preparation Products

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View Lastest Price from 4-Hydroxy-3,5-dimethoxycinnamic acid manufacturers

Wuhan Fortuna Chemical Co.,Ltd
Product
Sinapicacid 530-59-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5000kg
Release date
2024-08-28
Shanghai Standard Technology Co., Ltd.
Product
Sinapic acid 530-59-6
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-05-25
Career Henan Chemical Co
Product
4-Hydroxy-3,5-dimethoxycinnamic acid 530-59-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

530-59-6, 4-Hydroxy-3,5-dimethoxycinnamic acidRelated Search:

Hyaluronic acid 3-Hydroxycinnamic acid ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Dimethyldimethoxysilane CHLOROPHOSPHONAZO III 1,1-Dimethoxyethane Cinnamic acid Citric acid Diphenyldimethoxysilane 4-Hydroxycinnamic acid Folic acid 3,4-Dimethoxycinnamonitrile Mustardseed Oil Ethyl 2-(Chlorosulfonyl)acetate 4-Methoxycinnamic acid 2-HYDROXYCINNAMIC ACID Caffeic acid p-Coumaric acid

  • 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxycinnamic acid, Sinapic acid
  • 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapic acid, Sinapinic acid
  • 3,5-Dimethoxy-4-hydroxycinnamic acid, 98%, predominantly trans isomer
  • 3-(3,5-Dimethoxy-4-hydroxyphenyl)acrylic acid
  • 3-(4-Hydroxy-3,5-dimethoxyphenyl)propenoic acid
  • 3,5-Dimethoxy-4-hydroxybenzeneacrylic acid
  • Synapoic acid
  • 3-(4-Hydroxy-3,5-diMethoxyphenyl)-2-propenoic Acid
  • NSC 59261
  • Synapitic Acid
  • 4-Hydroxy-3,5-dimethoxycinnamic Acid Sinapinic Acid
  • SIMPLEXOLIN(RG)
  • Sinapic acid,3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid
  • Sinapinic Acid,3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapic acid, Sinapinic acid
  • Sinapinic acid 98%
  • Sinapic acid(4-Hydroxy-3,5-dimethoxycinnamic acid)
  • 5-Methoxyferulicacid
  • 4-Hydroxy-3,5-diMethoxycinnaMic Acid, PredoMinantly trans
  • (2E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid
  • 2-Propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-
  • 3,5-dimethoxy-4-hydroxycinnamicacid(sinapinicacid)
  • 3,5-dimethoxy-4-hydroxycinnamicacid,predominantlytransisomer
  • trans-3,5-Dimethoxy-4-hydroxycinnamic acid
  • LABOTEST-BB LT00233169
  • SINAPIC ACID
  • SINAPINIC ACID
  • RARECHEM BK HW 0169
  • Sinapic acid, >=98%
  • 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid
  • (E)-3-(4-hydroxy-3,5-diMethoxyphenyl)acrylic acid
  • 3,5-DIMETHOXY-4-HYDROXY-TRANS-CINNAMIC ACID
  • 3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID
  • 3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID, TRANS
  • 4-HYDROXY-3,5-DIMETHOXYCINNAMIC ACID
  • SINAPINIC ACID, USE TESTED FOR MALDI-TOF MASS SPEC
  • 3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID, 98 %, PREDOMINANTLY TRANS
  • SINAPIC ACID, PGE. WITH 10 X 10 MG
  • SINAPIC ACID, MATRIX SUBSTANCE FOR MALDI MS
  • Sinapinicacid=Sinapicacid
  • Sinapic acid (predominantly trans isomer)
  • Sinapic acid >=98%, powder
  • (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propenoate
  • Sinapinic acid (Synonyms: Sinapic acid)
  • 3,5-Dimethoxy-4-hydroxycinnamicAcid&gt
  • 3,5-Dimethoxy-4-hydroxycinnamicAcid[MatrixforMALDI-TOF/MS]&gt
  • Dimethoxy MS
  • rans-sinapicaci
  • 4-Hydroxy-3,5-dimethoxycinnamic acid USP/EP/BP
  • Sinapinic Acid (3,5-Dimethoxy-4-Hydroxy Cinnamic Acid Trans)98%
  • (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
  • 3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylic acid
  • (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
  • trans-3,5- Dimethoxy-4- Hydroxy cinamic acid
  • Esmolol Impurity 66
  • Sinapinic Acid (3,5-Dimethoxy-4-Hydroxy Cinnamic Acid Trans)
  • 1,4-Dioxino[2,3-f]quinazolin-10-amine,N-(3-ethynylphenyl)-2,3-dihydro-5-methoxy-
  • 530-59-6
  • 30-59-6