ChemicalBook > CAS DataBase List > 4-Hydroxy-3,5-dimethoxycinnamic acid

4-Hydroxy-3,5-dimethoxycinnamic acid

Product Name
4-Hydroxy-3,5-dimethoxycinnamic acid
CAS No.
530-59-6
Chemical Name
4-Hydroxy-3,5-dimethoxycinnamic acid
Synonyms
SINAPIC ACID;SINAPINIC ACID;3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID;(E)-3-(4-hydroxy-3,5-diMethoxyphenyl)acrylic acid;NSC 59261;Dimethoxy MS;Synapoic acid;Synapitic Acid;SIMPLEXOLIN(RG);rans-sinapicaci
CBNumber
CB8328696
Molecular Formula
C11H12O5
Formula Weight
224.21
MOL File
530-59-6.mol
More
Less

4-Hydroxy-3,5-dimethoxycinnamic acid Property

Melting point:
~202 °C
Boiling point:
285.61°C (rough estimate)
Density 
1.1478 (rough estimate)
refractive index 
1.4720 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: slightly soluble
form 
powder
pka
4.53±0.10(Predicted)
color 
white
Odor
at 100.00?%. odorless
Water Solubility 
insoluble
BRN 
2130006
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.
LogP
0.997 (est)
CAS DataBase Reference
530-59-6(CAS DataBase Reference)
NIST Chemistry Reference
Cinnamic acid, 4-hydroxy-3,5-dimethoxy-(530-59-6)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29189900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
85429
Product name
Sinapic acid
Purity
matrix substance for MALDI-MS, ≥99.0% (T)
Packaging
1g
Price
$91
Updated
2024/03/01
Sigma-Aldrich
Product number
49508
Product name
Sinapic acid
Purity
matrix substance for MALDI-MS, ≥99.5%, Ultra pure
Packaging
10x10mg
Price
$332
Updated
2024/03/01
TCI Chemical
Product number
D1765
Product name
3,5-Dimethoxy-4-hydroxycinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$57
Updated
2024/03/01
TCI Chemical
Product number
D1765
Product name
3,5-Dimethoxy-4-hydroxycinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$166
Updated
2024/03/01
Alfa Aesar
Product number
A15676
Product name
4-Hydroxy-3,5-dimethoxycinnamic acid, 98%
Packaging
1g
Price
$30.65
Updated
2024/03/01
More
Less

4-Hydroxy-3,5-dimethoxycinnamic acid Chemical Properties,Usage,Production

Chemical Properties

yellow-brown crystalline powder

Uses

4-Hydroxy-3,5-dimethoxycinnamic acid is a commonly used matrix in MALDI mass spectrometry. It is a useful matrix for a wide variety of peptides and proteins. It serves well as a matrix for MALDI due to its ability to absorb laser radiation and to also donate protons (H+) to the analyte of interest.

Uses

Sinapic acid was suitable as phenolic standard for HPLC analysis in determination of Sinapic acid derivatives in Canola extracts. 10 g/L of sinapinic acid with solvent was suitable as matrix for ultraviolet laser desorption mass spectrometric determination of proteins. It was also suitable to use as matrix for MALDI-TOFMS and MALDI-ion mobility-TOFMS to determine phospholipids in tissue.

Definition

ChEBI: A monohydroxycinnamic acid that is cinnamic acid in which the phenyl hydrogens at positions 3, 4, and 5 are replaced by methoxy, hydroxy, and methoxy groups, respectively.

General Description

Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.

Biochem/physiol Actions

On removal of amino group from phenylalanine, catalysing with enzyme phenylalanine ammonia-lyase forms cinnamic acid. The precursor of hydroxycinnamates is produced after hydroxylation of benzene ring. One of the precursors produced is sinapic acid. Sinapic acid exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anti-anxiety activity. Sinapine (sinapoyl choline) has been acknowledged as an acetylcholinesterase inhibitor, making it therapeutically applicable in treatment of various diseases. 4-Vinylsyringol (a decarboxylation product of sinapic acid) is a potent antimutagenic and antioxidative agent, involved in suppressing the induction of inflammatory cytokines and carcinogenesis. Owing to their anti-oxidative activity, these compounds have been considered to be potentially employed in the pharmaceutical industry, cosmetics and food processing.

Purification Methods

Crystallise it from water. [Beilstein 10 H 508, 10 IV 2104.]

4-Hydroxy-3,5-dimethoxycinnamic acid Preparation Products And Raw materials

Raw materials

Piperidine 3,4,5-Trimethoxybenzaldehyde Ethyl hydrogen malonate Hydrochloric acid Pyridine

Preparation Products

More
Less

4-Hydroxy-3,5-dimethoxycinnamic acid Suppliers

Americas 1 Australia 1 Belgium 1 Canada 1 China 225 Czech Republic 1 Europe 1 France 2 Germany 5 India 21 Japan 4 Slovakia 1 Switzerland 3 United Kingdom 18 United States 41 Global 326
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11369
Advantage
59
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40240
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44700
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35906
Advantage
56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11605
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42959
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Shanghai Aobo pharmaceutical Technology Co., Ltd
Tel
86-21-51320499
Fax
86-21-51320368
Email
aobo@aobopharm.com
Country
China
ProdList
298
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
RYSS TECH LTD
Tel
400-188-0725 +86 21 34310725 13611771617
Fax
+86 21 34311076
Country
China
ProdList
2002
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4554
Advantage
62
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5654
Advantage
65
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
SALES@UHNSHANGHAI.COM
Country
China
ProdList
977
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25009
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
971
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7784
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8072
Advantage
58
Chengdu Herbpurify Co.Ltd.
Tel
18302802153 18981717076
Fax
086-28-85377358
Email
2355253619@qq.com
Country
China
ProdList
1104
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9902
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41463
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18021
Advantage
56
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16168
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8147
Advantage
55
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6490
Advantage
50
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9957
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17698
Advantage
55
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
sales@chemwill.com
Country
China
ProdList
1975
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5908
Advantage
65
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
More
Less

View Lastest Price from 4-Hydroxy-3,5-dimethoxycinnamic acid manufacturers

Wuhan Fortuna Chemical Co.,Ltd
Product
Sinapicacid 530-59-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5000kg
Release date
2024-08-28
Shanghai Standard Technology Co., Ltd.
Product
Sinapic acid 530-59-6
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-05-25
Career Henan Chemical Co
Product
4-Hydroxy-3,5-dimethoxycinnamic acid 530-59-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

530-59-6, 4-Hydroxy-3,5-dimethoxycinnamic acidRelated Search:

Hyaluronic acid 3-Hydroxycinnamic acid ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Dimethyldimethoxysilane CHLOROPHOSPHONAZO III 1,1-Dimethoxyethane Cinnamic acid Citric acid Diphenyldimethoxysilane 4-Hydroxycinnamic acid Folic acid 3,4-Dimethoxycinnamonitrile Mustardseed Oil Ethyl 2-(Chlorosulfonyl)acetate 4-Methoxycinnamic acid 2-HYDROXYCINNAMIC ACID Caffeic acid p-Coumaric acid

  • 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxycinnamic acid, Sinapic acid
  • 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapic acid, Sinapinic acid
  • 3,5-Dimethoxy-4-hydroxycinnamic acid, 98%, predominantly trans isomer
  • 3-(3,5-Dimethoxy-4-hydroxyphenyl)acrylic acid
  • 3-(4-Hydroxy-3,5-dimethoxyphenyl)propenoic acid
  • 3,5-Dimethoxy-4-hydroxybenzeneacrylic acid
  • Synapoic acid
  • 3-(4-Hydroxy-3,5-diMethoxyphenyl)-2-propenoic Acid
  • NSC 59261
  • Synapitic Acid
  • 4-Hydroxy-3,5-dimethoxycinnamic Acid Sinapinic Acid
  • SIMPLEXOLIN(RG)
  • Sinapic acid,3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid
  • Sinapinic Acid,3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapic acid, Sinapinic acid
  • Sinapinic acid 98%
  • Sinapic acid(4-Hydroxy-3,5-dimethoxycinnamic acid)
  • 5-Methoxyferulicacid
  • 4-Hydroxy-3,5-diMethoxycinnaMic Acid, PredoMinantly trans
  • (2E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid
  • 2-Propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-
  • 3,5-dimethoxy-4-hydroxycinnamicacid(sinapinicacid)
  • 3,5-dimethoxy-4-hydroxycinnamicacid,predominantlytransisomer
  • trans-3,5-Dimethoxy-4-hydroxycinnamic acid
  • LABOTEST-BB LT00233169
  • SINAPIC ACID
  • SINAPINIC ACID
  • RARECHEM BK HW 0169
  • Sinapic acid, >=98%
  • 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid
  • (E)-3-(4-hydroxy-3,5-diMethoxyphenyl)acrylic acid
  • 3,5-DIMETHOXY-4-HYDROXY-TRANS-CINNAMIC ACID
  • 3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID
  • 3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID, TRANS
  • 4-HYDROXY-3,5-DIMETHOXYCINNAMIC ACID
  • SINAPINIC ACID, USE TESTED FOR MALDI-TOF MASS SPEC
  • 3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID, 98 %, PREDOMINANTLY TRANS
  • SINAPIC ACID, PGE. WITH 10 X 10 MG
  • SINAPIC ACID, MATRIX SUBSTANCE FOR MALDI MS
  • Sinapinicacid=Sinapicacid
  • Sinapic acid (predominantly trans isomer)
  • Sinapic acid >=98%, powder
  • (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propenoate
  • Sinapinic acid (Synonyms: Sinapic acid)
  • 3,5-Dimethoxy-4-hydroxycinnamicAcid&gt
  • 3,5-Dimethoxy-4-hydroxycinnamicAcid[MatrixforMALDI-TOF/MS]&gt
  • Dimethoxy MS
  • rans-sinapicaci
  • 4-Hydroxy-3,5-dimethoxycinnamic acid USP/EP/BP
  • Sinapinic Acid (3,5-Dimethoxy-4-Hydroxy Cinnamic Acid Trans)98%
  • (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
  • 3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylic acid
  • (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
  • trans-3,5- Dimethoxy-4- Hydroxy cinamic acid
  • Esmolol Impurity 66
  • Sinapinic Acid (3,5-Dimethoxy-4-Hydroxy Cinnamic Acid Trans)
  • 1,4-Dioxino[2,3-f]quinazolin-10-amine,N-(3-ethynylphenyl)-2,3-dihydro-5-methoxy-
  • 530-59-6
  • 30-59-6