Biotin-PEG4-Methyltetrazine

Product Name: Biotin-PEG4-Methyltetrazine
CAS No.: 1835759-81-3
Chemical Name: Biotin-PEG4-Methyltetrazine
Synonyms: Biotin-PEG4-Methyltetrazine;N-(2-(2-(2-(2-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide;1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-2-oxo-, (3aR,4R,6aS)-rel-
CBNumber: CB83344947
Molecular Formula: C27H39N7O6S
Formula Weight: 589.71
MOL File: 1835759-81-3.mol

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Biotin-PEG4-Methyltetrazine Property

Density: 1.233±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, sealed storage, away from moisture
solubility: Soluble in DMSO, DMF
pka: 13.90±0.40(Predicted)
form: Solid
color: Purple to purplish red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22939
Product name: Biotin-PEG4-methyltetrazine
Purity: 95%
Packaging: 25mg
Price: $195
Updated: 2021/12/16

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Biotin-PEG4-Methyltetrazine Chemical Properties,Usage,Production

Description

Biotin-PEG4-methyltetrazine is a click chemistry biotinylation reagent that can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity.

Uses

Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Biotin-PEG4-Methyltetrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Biotin-PEG4-Methyltetrazine manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Biotin-PEG4-methyltetrazine 1835759-81-3
Price: US $0.00/mg
Min. Order: 25mg
Purity: >97.00%
Supply Ability: 100mg
Release date: 2024-03-20

1835759-81-3, Biotin-PEG4-MethyltetrazineRelated Search:

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Biotin-PEG4-Methyltetrazine

1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-2-oxo-, (3aR,4R,6aS)-rel-

N-(2-(2-(2-(2-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

1835759-81-3

C27H39N7O6S