E3 ligase Ligand-Linker Conjugates 6

Product Name: E3 ligase Ligand-Linker Conjugates 6
CAS No.: 2097973-72-1
Chemical Name: E3 ligase Ligand-Linker Conjugates 6
Synonyms: VHL-PEG2-NH2 HCl;VH032-PEG2-NH2 hydrochloride;S)-AHPC-PEG2-NH2 hydrochloride;(S,R,S)-AHPC-PEG2-NH2 hydrochloride;E3 ligase Ligand-Linker Conjugates 6;(S,R,S)-AHPC-PEG2-NH2 hydrochloride >=95%;VHL Ligand-Linker Conjugates 3 hydrochloride;(S,R,S)-AHPC-PEG2-NH2 hydrochloride, 10 mM in DMSO;(S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6);(S,R,S)-AHPC-PEG₂-NH₂ hydrochloride
CBNumber: CB83386473
Molecular Formula: C28H42ClN5O6S
Formula Weight: 612.18
MOL File: 2097973-72-1.mol

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E3 ligase Ligand-Linker Conjugates 6 Property

storage temp.: 2-8°C
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901488
Product name: (S,R,S)-AHPC-PEG2-NH2 hydrochloride
Purity: ≥95%
Packaging: 50MG
Price: $738
Updated: 2025/07/31

Iris Biotech GmbH

Product number: PTC1320
Product name: (S,R,S)-AHPC-PEG2-NH2 hydrochloride
Packaging: 50mg
Price: $499.5
Updated: 2021/12/16

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E3 ligase Ligand-Linker Conjugates 6 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG₂-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

IC 50

VHL

E3 ligase Ligand-Linker Conjugates 6 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from E3 ligase Ligand-Linker Conjugates 6 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG2-NH2 hydrochloride 2097973-72-1
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-04-01

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E3 ligase Ligand-Linker Conjugates 6

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

VH032-PEG2-NH2 hydrochloride

VHL Ligand-Linker Conjugates 3 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 hydrochloride >=95%

(S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6)

(2S,4R)-1-((S)-2-(2-(2-(2-aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

S)-AHPC-PEG2-NH2 hydrochloride

inhibit,E3 Ligase Ligand-Linker Conjugates,Inhibitor,VHL Ligand-Linker Conjugates 3,(S,R,S) AHPC PEG2 NH2 hydrochloride,(S,R,S)AHPCPEG2NH2 hydrochloride,(S,R,S)-AHPC-PEG-2-NH2 hydrochloride

(2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

(S,R,S)-AHPC-PEG2-NH2 hydrochloride, 10 mM in DMSO

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

VHL-PEG2-NH2 HCl

2097973-72-1