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E3 ligase Ligand-Linker Conjugates 6

Product Name
E3 ligase Ligand-Linker Conjugates 6
CAS No.
2097973-72-1
Chemical Name
E3 ligase Ligand-Linker Conjugates 6
Synonyms
VH032-PEG2-NH2 hydrochloride;S)-AHPC-PEG2-NH2 hydrochloride;(S,R,S)-AHPC-PEG2-NH2 hydrochloride;E3 ligase Ligand-Linker Conjugates 6;(S,R,S)-AHPC-PEG2-NH2 hydrochloride >=95%;VHL Ligand-Linker Conjugates 3 hydrochloride;(S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6);(2S,4R)-1-((S)-2-(2-(2-(2-aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;inhibit,E3 Ligase Ligand-Linker Conjugates,Inhibitor,VHL Ligand-Linker Conjugates 3,(S,R,S) AHPC PEG2 NH2 hydrochloride,(S,R,S)AHPCPEG2NH2 hydrochloride,(S,R,S)-AHPC-PEG-2-NH2 hydrochloride;(2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber
CB83386473
Molecular Formula
C28H42ClN5O6S
Formula Weight
612.18
MOL File
2097973-72-1.mol
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E3 ligase Ligand-Linker Conjugates 6 Property

storage temp. 
2-8°C
form 
Solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901488
Product name
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
Purity
≥95%
Packaging
50MG
Price
$688
Updated
2023/06/20
Iris Biotech GmbH
Product number
PTC1320
Product name
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
Packaging
50mg
Price
$499.5
Updated
2021/12/16
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E3 ligase Ligand-Linker Conjugates 6 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG2-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 6 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 6 Suppliers

China 24 India 1 United States 2 Global 27
ChemShuttle, Inc.
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 6 manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
(S,R,S)-AHPC-PEG2-NH2 hydrochloride 2097973-72-1
Price
US $0.00/mg
Min. Order
100mg
Purity
>98.00%
Supply Ability
100mg
Release date
2024-04-01

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  • E3 ligase Ligand-Linker Conjugates 6
  • (S,R,S)-AHPC-PEG2-NH2 hydrochloride
  • VH032-PEG2-NH2 hydrochloride
  • VHL Ligand-Linker Conjugates 3 hydrochloride
  • (S,R,S)-AHPC-PEG2-NH2 hydrochloride >=95%
  • (S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6)
  • (2S,4R)-1-((S)-2-(2-(2-(2-aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
  • S)-AHPC-PEG2-NH2 hydrochloride
  • inhibit,E3 Ligase Ligand-Linker Conjugates,Inhibitor,VHL Ligand-Linker Conjugates 3,(S,R,S) AHPC PEG2 NH2 hydrochloride,(S,R,S)AHPCPEG2NH2 hydrochloride,(S,R,S)-AHPC-PEG-2-NH2 hydrochloride
  • (2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
  • 2097973-72-1