3-Bromo-2-chloropyridine
- Product Name
- 3-Bromo-2-chloropyridine
- CAS No.
- 52200-48-3
- Chemical Name
- 3-Bromo-2-chloropyridine
- Synonyms
- 2-CHLORO-3-BROMOPYRIDINE;3-Bromo-2-chL;TIMTEC-BB SBB003618;OTAVA-BB BB7110952626;-Bromo-2-chloropyridine;3-BROMO-2-CHLOROPYRIDINE;bromo-3 chloro-2 pyridine;3-Bromo-2-chlorolpyridine;Pyridine, 3-bromo-2-chloro-;5-Bromo-3-nitro-3-pyridinol
- CBNumber
- CB8375195
- Molecular Formula
- C5H3BrClN
- Formula Weight
- 192.44
- MOL File
- 52200-48-3.mol
3-Bromo-2-chloropyridine Property
- Melting point:
- 54-57 °C (lit.)
- Boiling point:
- 97 °C / 10mmHg
- Density
- 1.7783 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.63±0.10(Predicted)
- form
- Crystalline Powder, Crystals or Flakes or Solid
- color
- White to yellow
- BRN
- 109812
- InChI
- InChI=1S/C5H3BrClN/c6-4-2-1-3-8-5(4)7/h1-3H
- InChIKey
- HDYNIWBNWMFBDO-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1Br
- CAS DataBase Reference
- 52200-48-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 553751
- Product name
- 3-Bromo-2-chloropyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $22.24
- Updated
- 2025/07/31
- Product number
- 553751
- Product name
- 3-Bromo-2-chloropyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $59.57
- Updated
- 2025/07/31
- Product number
- B2328
- Product name
- 3-Bromo-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- B2328
- Product name
- 3-Bromo-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $82
- Updated
- 2025/07/31
- Product number
- B682305
- Product name
- 3-Bromo-2-chloropyridine
- Packaging
- 250g
- Price
- $725
- Updated
- 2021/12/16
3-Bromo-2-chloropyridine Chemical Properties,Usage,Production
Chemical Properties
yellow Long needles
Uses
3-Bromo-2-chloropyridine may be used to synthesize:
- acetylenic dipyridone
- 3-ethynyl-2-(phenylmethoxy)-pyridine
- nemertelline
- ortho-chlorodiheteroarylamine4 or 2-chloro-N-(2,3,7-trimethylbenzo[b]thien-6-yl)pyridin-3-amine
General Description
3-Bromo-2-chloropyridine can be synthesized from 3-amino-2-chloropyridine or 2-chloro-3-pyridinamine.
Synthesis
6298-19-7
52200-48-3
Example 3 Synthesis of 3-bromo-2-chloropyridine (7): water (45 mL) and 48% hydrobromic acid (27 mL) were sequentially added to a reaction vial containing 3-amino-2-chloropyridine (6) (2.57 g, 20 mmol) at room temperature. Subsequently, 2,2,6,6-tetramethylpiperidine 1-yloxy (TEMPO) (0.31 g, 2 mmol) was added to the mixed solution and the reaction system was cooled to below 10 °C. A solution of sodium nitrite (4.14 g) dissolved in water (30 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for about 2 h. After stirring, the reaction mixture was neutralized by adding a 10 mol/L aqueous sodium hydroxide solution (40 mL). The reaction mixture was extracted with toluene (300 mL in two portions) and the organic phases were combined and washed with 50 mL of water. The organic layer was concentrated under reduced pressure to remove the solvent to afford the target product 3-bromo-2-chloropyridine (7) (3.08 g, 80.1% yield).
References
[1] Patent: US2013/144061, 2013, A1. Location in patent: Paragraph 0229; 0230
[2] Journal of Organic Chemistry, 1995, vol. 60, # 5, p. 1408 - 1412
3-Bromo-2-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-2-chloropyridine Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 3-Bromo-2-chloropyridine manufacturers
- Product
- 3-Bromo-2-chloropyridine 52200-48-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 3-Bromo-2-chloropyridine 52200-48-3
- Price
- US $100.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg
- Release date
- 2021-09-13
- Product
- 3-Bromo-2-chloropyridine 52200-48-3
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-15