ChemicalBook > CAS DataBase List > 3',5'-Bis(trifluoromethyl)acetophenone

3',5'-Bis(trifluoromethyl)acetophenone

Uses

Product Name: 3',5'-Bis(trifluoromethyl)acetophenone
CAS No.: 30071-93-3
Chemical Name: 3',5'-Bis(trifluoromethyl)acetophenone
Synonyms: MBT-AC;2-Phenyl-4’TIMTEC-BB SBB005963;3',5'-Bis(trifluorom;Acifluorfen Impurity 5;3,5-(CF3)2-acetophenone;3,5-BIS(TRIFLUOROMETHYL);3, 5 - two-trifluoroMethyl;TRIFLUOROMETHYL ACETOPHENONE;3,5-Di(trifluoromethyl)hypnone
CBNumber: CB8391658
Molecular Formula: C10H6F6O
Formula Weight: 256.14
MOL File: 30071-93-3.mol

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3',5'-Bis(trifluoromethyl)acetophenone Property

Boiling point:: 95-98 °C (15 mmHg)
Density: 1.422 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4221(lit.)
Flash point:: 180 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow
Specific Gravity: 1.422
BRN: 2384789
InChI: InChI=1S/C10H6F6O/c1-5(17)6-2-7(9(11,12)13)4-8(3-6)10(14,15)16/h2-4H,1H3
InChIKey: MCYCSIKSZLARBD-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C
CAS DataBase Reference: 30071-93-3(CAS DataBase Reference)
NIST Chemistry Reference: 3',5'-Bis(trifluoromethyl)acetophenone(30071-93-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39-36
RIDADR: 3439
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 263362
Product name: 3′,5′-Bis(trifluoromethyl)acetophenone
Purity: 98%
Packaging: 5g
Price: $32.4
Updated: 2025/07/31

TCI Chemical

Product number: B1949
Product name: 3',5'-Bis(trifluoromethyl)acetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: B1949
Product name: 3',5'-Bis(trifluoromethyl)acetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $41
Updated: 2025/07/31

TRC

Product number: T784070
Product name: 3'',5''-Bis(Trifluoromethyl)acetophenone
Packaging: 5g
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2817-3-08
Product name: 3',5'-Bis(trifluoromethyl)acetophenone
Purity: 98%
Packaging: 10g
Price: $10
Updated: 2021/12/16

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3',5'-Bis(trifluoromethyl)acetophenone Chemical Properties,Usage,Production

Uses

3',5'-Bis(Trifluoromethyl)acetophenone is a reactant that has been used in the preparation of pyrazole carboxamide derivatives with antibacterial and antifungal activity.

Chemical Properties

CLEAR PALE YELLOW LIQUID

Uses

3'',5''-Bis(Trifluoromethyl)acetophenone is a reactant that has been used in the preparation of pyrazole carboxamide derivatives with antibacterial and antifungal activity.

Synthesis Reference(s)

The Journal of Organic Chemistry, 68, p. 3695, 2003 DOI: 10.1021/jo026903n

Synthesis

68120-60-5

30071-93-3

General procedure for the synthesis of 3,5-bis(trifluoromethyl)acetophenone from (R)-1-[3,5-bis(trifluoromethyl)-phenyl]ethanol: BTC (0.41 g, 1.39 mmol) was dissolved in anhydrous dichloromethane (5 mL) under the protection of nitrogen and cooled to -15 °C in an ice-salt bath. At this temperature, a solution of (R)-1-[3,5-bis(trifluoromethyl)-phenyl]ethanol (1.24 g, 4.17 mmol) in anhydrous dichloromethane (5 mL) was slowly added dropwise for 0.5 hours. After continued stirring for 0.5 h, an anhydrous dichloromethane (5 mL) solution of benzyl alcohol (0.3 g, 2.78 mmol) was added dropwise for 0.5 h at the same temperature. After stirring for 0.5 h, triethylamine (0.84 g, 8.34 mmol) was slowly added while making sure that the reaction temperature was kept below -15 °C. Upon completion of the reaction, 10% aqueous hydrochloric acid was added dropwise under ice bath conditions until the pH of the reaction mixture reached 2. The organic layer was separated by extracting the mixture with hexane or petroleum ether (10 mL x 2). After concentration of the organic layer, it was purified by fast chromatography (silica gel; hexane) to afford the target product 3,5-bis(trifluoromethyl)acetophenone (0.27 g, 92% yield). The aqueous layer can be used to recover by-product V and excess (R)-1-[3,5-bis(trifluoromethyl)-phenyl]ethanol.

References

[1] Synthetic Communications, 2016, vol. 46, # 10, p. 885 - 892
[2] Patent: WO2004/94358, 2004, A1. Location in patent: Page 4-5
[3] Patent: WO2004/94358, 2004, A1. Location in patent: Page 5
[4] European Journal of Organic Chemistry, 2018, vol. 2018, # 23, p. 3031 - 3035

3',5'-Bis(trifluoromethyl)acetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3',5'-Bis(trifluoromethyl)acetophenone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-(3,5-Bis(trifluoromethyl)phenyl)ethanone 30071-93-3
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-09-08

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3',5'-Bis(trifluoromethyl)acetophenone 30071-93-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-21

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3',5'-Bis(trifluoromethyl)acetophenone 30071-93-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

30071-93-3, 3',5'-Bis(trifluoromethyl)acetophenoneRelated Search:

Chalcone 4-Fluoroacetophenone Acetophenone 4'-Methylacetophenone 3'-Methylacetophenone Trifluoroacetophenone 2-(Trifluoromethyl)benzoic acid 3-(Trifluoromethyl)benzaldehyde Trifluoromethanesulfonic acid 2-Aminobenzotrifluoride 4'-(Trifluoromethyl)acetophenone 3',5'-BIS(TRIFLUOROMETHYL)-2-BROMOACETOPHENONE ETHYL 3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-3-OXOPROPANOATE 2-[3,5-BIS(TRIFLUOROMETHYL)BENZOYL]BENZOIC ACID 3,5-BIS(TRIFLUOROMETHYL)BENZOPHENONE 3,3',5,5'-TETRAKIS(TRIFLUOROMETHYL)BENZOPHENONE 3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE Trifluoromethyl

TRIFLUOROMETHYL ACETOPHENONE

3',5'-Bis(trifluoromethyl)acetophenone 98%

3,5-BIS(TRIFLUOROMETHYL)

3,5-Di(trifluoromethyl)hypnone

3',5'-Bis(trifluorom

1-[3,5-bis(trifluoromethyl)phenyl]ethan-1-one

3.5-Bis（trifluoromethyl）acetopenone

1-[3,5-bis(trifluoromethyl)phenyl]ethanone （Aprepitant）

3,5-Bis(trifluoromethly)acetophenone

2-Phenyl-4&rsquo

3,5-(CF3)2-acetophenone

3, 5 - two-trifluoroMethyl

1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-one, 5-Acetyl-alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-m-xylene

3',5'-Bis(trifluoroMethyl)acetophenone, 97+%

3, 5 - double three fluorinated Methyl acetophenone

Ethanone, 1-[3,5-bis(trifluoromethyl)phenyl]-

TIMTEC-BB SBB005963

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANONE

1-[3,5-DI(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE

3,5-DI(TRIFLUOROMETHYL)ACETOPHENONE

3',5'-BIS(TRIFTUAROMETHYL)ACETOPHENONE

3',5'-BIS(TRIFLUOROMETHYL)ACETOPHENONE

3,5-BIS(TRIFLUOROMETHYL)ACETOPHENONE

MBT-AC

3',5'-di(trifluoromethyl)-acetophenone radical

3',5'-Bis(trifluoromethyl)acetophenone &gt

3,5-Bis(trifluoromethyl)phenyl ethanone

3’,5’-Bis(trifluoromethyl)acetophenone

Acifluorfen Impurity 5

3,5-Bis(trifluoromethyl)benzophenone (Aripiprazole)

30071-93-3

30071-93-9

30071-93-1

C10H6F6O

CF32C6H3COCH3

C10H6OF6

KETONE

Ketones

Organic Building Blocks

Building Blocks

C10

Carbonyl Compounds

C10

Carbonyl Compounds

Ketones

Miscellaneous

Boronic Acid series

PHARMACEUTICAL INTERMEDIATES

Aromatic Acetophenones & Derivatives (substituted)

ketone

Fluorides

Trifluoromethylbenzene serise

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Indolines ,Indoles

30071-93-3