3',5'-Bis(trifluoromethyl)acetophenone
Uses- Product Name
- 3',5'-Bis(trifluoromethyl)acetophenone
- CAS No.
- 30071-93-3
- Chemical Name
- 3',5'-Bis(trifluoromethyl)acetophenone
- Synonyms
- MBT-AC;2-Phenyl-4’TIMTEC-BB SBB005963;3',5'-Bis(trifluorom;Acifluorfen Impurity 5;3,5-(CF3)2-acetophenone;3,5-BIS(TRIFLUOROMETHYL);3, 5 - two-trifluoroMethyl;TRIFLUOROMETHYL ACETOPHENONE;3,5-Di(trifluoromethyl)hypnone
- CBNumber
- CB8391658
- Molecular Formula
- C10H6F6O
- Formula Weight
- 256.14
- MOL File
- 30071-93-3.mol
3',5'-Bis(trifluoromethyl)acetophenone Property
- Boiling point:
- 95-98 °C (15 mmHg)
- Density
- 1.422 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.4221(lit.)
- Flash point:
- 180 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow
- Specific Gravity
- 1.422
- BRN
- 2384789
- InChI
- InChI=1S/C10H6F6O/c1-5(17)6-2-7(9(11,12)13)4-8(3-6)10(14,15)16/h2-4H,1H3
- InChIKey
- MCYCSIKSZLARBD-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C
- CAS DataBase Reference
- 30071-93-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 3',5'-Bis(trifluoromethyl)acetophenone(30071-93-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37/39-36
- RIDADR
- 3439
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 263362
- Product name
- 3′,5′-Bis(trifluoromethyl)acetophenone
- Purity
- 98%
- Packaging
- 5g
- Price
- $32.4
- Updated
- 2025/07/31
- Product number
- B1949
- Product name
- 3',5'-Bis(trifluoromethyl)acetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $19
- Updated
- 2025/07/31
- Product number
- B1949
- Product name
- 3',5'-Bis(trifluoromethyl)acetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- T784070
- Product name
- 3'',5''-Bis(Trifluoromethyl)acetophenone
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 2817-3-08
- Product name
- 3',5'-Bis(trifluoromethyl)acetophenone
- Purity
- 98%
- Packaging
- 100g
- Price
- $50
- Updated
- 2021/12/16
3',5'-Bis(trifluoromethyl)acetophenone Chemical Properties,Usage,Production
Uses
3',5'-Bis(Trifluoromethyl)acetophenone is a reactant that has been used in the preparation of pyrazole carboxamide derivatives with antibacterial and antifungal activity.
Chemical Properties
CLEAR PALE YELLOW LIQUID
Uses
3'',5''-Bis(Trifluoromethyl)acetophenone is a reactant that has been used in the preparation of pyrazole carboxamide derivatives with antibacterial and antifungal activity.
Synthesis Reference(s)
The Journal of Organic Chemistry, 68, p. 3695, 2003 DOI: 10.1021/jo026903n
Synthesis
68120-60-5
30071-93-3
General procedure for the synthesis of 3,5-bis(trifluoromethyl)acetophenone from (R)-1-[3,5-bis(trifluoromethyl)-phenyl]ethanol: BTC (0.41 g, 1.39 mmol) was dissolved in anhydrous dichloromethane (5 mL) under the protection of nitrogen and cooled to -15 °C in an ice-salt bath. At this temperature, a solution of (R)-1-[3,5-bis(trifluoromethyl)-phenyl]ethanol (1.24 g, 4.17 mmol) in anhydrous dichloromethane (5 mL) was slowly added dropwise for 0.5 hours. After continued stirring for 0.5 h, an anhydrous dichloromethane (5 mL) solution of benzyl alcohol (0.3 g, 2.78 mmol) was added dropwise for 0.5 h at the same temperature. After stirring for 0.5 h, triethylamine (0.84 g, 8.34 mmol) was slowly added while making sure that the reaction temperature was kept below -15 °C. Upon completion of the reaction, 10% aqueous hydrochloric acid was added dropwise under ice bath conditions until the pH of the reaction mixture reached 2. The organic layer was separated by extracting the mixture with hexane or petroleum ether (10 mL x 2). After concentration of the organic layer, it was purified by fast chromatography (silica gel; hexane) to afford the target product 3,5-bis(trifluoromethyl)acetophenone (0.27 g, 92% yield). The aqueous layer can be used to recover by-product V and excess (R)-1-[3,5-bis(trifluoromethyl)-phenyl]ethanol.
References
[1] Synthetic Communications, 2016, vol. 46, # 10, p. 885 - 892
[2] Patent: WO2004/94358, 2004, A1. Location in patent: Page 4-5
[3] Patent: WO2004/94358, 2004, A1. Location in patent: Page 5
[4] European Journal of Organic Chemistry, 2018, vol. 2018, # 23, p. 3031 - 3035
3',5'-Bis(trifluoromethyl)acetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
3',5'-Bis(trifluoromethyl)acetophenone Suppliers
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View Lastest Price from 3',5'-Bis(trifluoromethyl)acetophenone manufacturers
- Product
- 1-(3,5-Bis(trifluoromethyl)phenyl)ethanone 30071-93-3
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
- Product
- 3',5'-Bis(trifluoromethyl)acetophenone 30071-93-3
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-21
- Product
- 3',5'-Bis(trifluoromethyl)acetophenone 30071-93-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24