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ChemicalBook > CAS DataBase List > EC 1.1.1.42

EC 1.1.1.42

Description Source Background
Product Name
EC 1.1.1.42
CAS No.
9028-48-2
Chemical Name
EC 1.1.1.42
Synonyms
IDH;ICDH;IDH1;IDHM;IDPM;IDCD;PICD;ICD-M;D2HGA2;HEL-216
CBNumber
CB8395171
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
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EC 1.1.1.42 Property

storage temp. 
2-8°C
form 
solution (clear)
color 
yellow-brown
biological source
Porcine heart
Specific Activity
3-20units/mg protein
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Safety

WGK Germany 
3
F 
10
HS Code 
3507909090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I5036
Product name
Isocitrate Dehydrogenase 1 (NADP+) human
Purity
recombinant, expressed in E. coli, lyophilized powder, ≥80?units/mg protein
Packaging
100μg
Price
$506.35
Updated
2025/07/31
Sigma-Aldrich
Product number
I2411
Product name
Isocitrate Dehydrogenase 1 (NADP+) human
Purity
recombinant, expressed in Sf9 cells, ≥90% (SDS-PAGE)
Packaging
10μg
Price
$740
Updated
2025/07/31
Sigma-Aldrich
Product number
I1877
Product name
Isocitric Dehydrogenase (NADP) from porcine heart
Purity
Type I, 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)
Packaging
500mg
Price
$225
Updated
2025/07/31
Sigma-Aldrich
Product number
I1877
Product name
Isocitric Dehydrogenase (NADP) from porcine heart
Purity
Type I, 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)
Packaging
1g
Price
$403.75
Updated
2025/07/31
Sigma-Aldrich
Product number
I2002
Product name
Isocitric Dehydrogenase (NADP) from porcine heart
Purity
Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein
Packaging
25mg
Price
$122
Updated
2025/07/31
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EC 1.1.1.42 Chemical Properties,Usage,Production

Uses

Human Isocitrate Dehydrogenase (IDH1) is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It may be useful as a biomarker for diagnosis and prognosis prediction of non-small cell lung cancer .

General Description

Isocitrate dehydrogenase 1 (IDH1) gene is located on human chromosome 2q33. IDH1 is present in the cytoplasm and peroxisomes. It is expressed at high levels in the mammalian liver. IDH1 consists of a C-terminal tripeptide peroxisome, that targets the signal one sequence.

Biochem/physiol Actions

Isocitrate dehydrogenase 1 (IDH1) help in the oxidative carboxylation of isocitrate to α-ketoglutarate, that results in the formation of reduced nicotinamide adenine dinucleotide phosphate (NADPH). It participates in lipid metabolism and glucose sensing. Suppressing IDH1 in pancreatic islets affects the insulin secretion, induced by glucose and leads to increase in lactate production.

Description

Recombinant Saccharomyces Cerevisiae ICDH (NADP) derived from yeast host cells by using over-expression system, is full length same as designated ICD1 from Saccharomyces Cerevisiae. The N-terminal amino acid Phenylalanine residue next to Met is substituted with Alanine for overexpression.
The ICDH is purified by proprietary chromatographic techniques.

Source

Yeast cells

Background

Isocitrate Dehydrogenase is an enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle.

EC 1.1.1.42 Preparation Products And Raw materials

Raw materials

Preparation Products

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EC 1.1.1.42 Suppliers

China 83 France 1 Switzerland 1 United Kingdom 1 United States 3 Global 89
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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China
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18515581800 18501085097
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sales.bj@hwrkchemical.com
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021-64823266
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China
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0731-85526065 13308475853
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China
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China
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Shanghai Macklin Biochemical Co.,Ltd.
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15221275939
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021-50706099
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shenlinxing@macklin.cn
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China
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Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
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51395
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Beijing NuoqiYa Biotechnology Co., Ltd.
Tel
4000-819-385 010-62329685 13718666987
Fax
010-62340519
Country
China
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1971
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View Lastest Price from EC 1.1.1.42 manufacturers

Career Henan Chemical Co
Product
EC 1.1.1.42 9028-48-2
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

9028-48-2, EC 1.1.1.42Related Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE N-BUTYLISOCYANIDE METHYL ISOCYANOACETATE Ethyl isocyanoacetate Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) SALCOMINE COBALT(II) ACETYLACETONATE PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE Tris(2,4-pentanedionato)chroMiuM(III) TERT-BUTYL ISOCYANIDE Aluminum acetylacetonate Benzyl isocyanide Cupric acetylacetonate

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  • THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING] TYPE IV
  • isocitrate dehydrogenase from porcine heart
  • ICDH
  • ISOCITRIC DEHYDROGENASE (NADP)
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  • EC 1.1.1.42
  • EC 1.1.1.42 TYPE I
  • EC 1.1.1.42 TYPE IV
  • ISOCITRAT DEHYDROGENASE FROM PORCINE HEA RT, 3-8 U/MG
  • ISOCITRIC DEHYDROGENASE TYPE IV FROM*POR CINE HEART
  • ISOCITRATE DEHYDROGENASE FROM PORCINE HE ART, ~10 U/MG
  • ISOCITRIC DEHYDROGENASE TYPE I CRUDE*FRO M PORCINE H
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  • Recombinant Isocitrate Dehydrogenase
  • isocitric dehydrogenase
  • ICDH, threo-Ds-Isocitrate: NADP+ oxidoreductase
  • Isocitric Dehydrogenase (NADP) from porcine heart,threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH
  • Isocitrate dehydrogenase (NAD+) recombinant from Yeast, 50% glycerol solution
  • rICDH (NADP), threo-Ds-Isocitrate: NAD oxidoreductase (decarboxylating)
  • rICDH (NAD), threo-Ds-Isocitrate: NAD oxidoreductase (decarboxylating)
  • IsoCltrate dehydrogenase
  • TPN-specific isocitrate dehydrogenase
  • TPN-linked isocitrate dehydrogenase
  • TPN-isocitrate dehydrogenase
  • TPN-dependent isocitrate dehydrogenase
  • Oxalosuccinic decarboxylase
  • Isocitrate Dehydrogenase preparation porcine heart
  • isocitric dehydrogenase type I crude*from porcine
  • Dehydrogenase, isocitrate (nicotinamide adenine dinucleotide phosphate)
  • ISOCITRIC DEHYDROGENASE HIGHLY PURIFIED FROM PORCIN
  • Isocitrate Dehydrogenase 1 (NADP+) huMan
  • IDH
  • IDH1
  • Isocitrate Dehydrogenase Cytoplasmic
  • MGC171441
  • MGC174090
  • MGC55806
  • Isocitric Dehydrogenase (NADP), Bacillus subtilis, recombinant from E. coli
  • NADP-specific isocitric dehydyrogenase
  • NADPH-dependent isocitrate dehydrogenase
  • Isocitrate Dehydrogenase (NADP+) from Bacteria, Recombinant
  • Native Porcine Isocitric Dehydrogenase (NADP)
  • Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant
  • Recombinant Human IDH1 C-his8 Protein, His Tag
  • Recombinant Human IDH1 Protein, His Tag
  • Isocitrate dehydrogenase from Bacillus subtilis, Recombinant
  • :THREO-DS-ISOCITRATE
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  • Isocitric Dehydrogenase (NADP) from porcine heart Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein
  • Isocitrate Dehydrogenase Activity Microplate Assay Kit
  • Recombinant Human IDH1 Protein (R132H, C-8His)
  • IDHM
  • IDPM