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5-AMINO-4-CHLOROPYRIMIDINE

Product Name
5-AMINO-4-CHLOROPYRIMIDINE
CAS No.
54660-78-5
Chemical Name
5-AMINO-4-CHLOROPYRIMIDINE
Synonyms
4-chloropyriMidin-5-aMine;Amino chloropyrimidine;4-Chloro-5-pyrimidinamine;4-Chloro-5-aMinopyriMidine;5-AMINO-4-CHLOROPYRIMIDINE;5-PYRIMIDINAMINE, 4-CHLORO-;4-chloro-pyriMidin-5-ylaMine;5-Amino-4-chloropyrimidine,96%;5-Pyrimidinamine, 4-chloro- (9CI)
CBNumber
CB8398804
Molecular Formula
C4H4ClN3
Formula Weight
129.55
MOL File
54660-78-5.mol
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5-AMINO-4-CHLOROPYRIMIDINE Property

Melting point:
110-116℃
Boiling point:
253.8±20.0 °C(Predicted)
Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
1.30±0.16(Predicted)
form 
Solid
color 
White to pale brown
Sensitive 
Air & Light Sensitive
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
732281
Product name
5-Amino-4-chloropyrimidine
Purity
97%
Packaging
500mg
Price
$32.5
Updated
2023/06/20
TCI Chemical
Product number
A2937
Product name
5-Amino-4-chloropyrimidine
Purity
>97.0%(GC)(T)
Packaging
200mg
Price
$60
Updated
2025/07/31
TCI Chemical
Product number
A2937
Product name
5-Amino-4-chloropyrimidine
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$239
Updated
2025/07/31
TRC
Product number
A617673
Product name
5-Amino-4-chloropyrimidine
Packaging
500mg
Price
$90
Updated
2021/12/16
Usbiological
Product number
295674
Product name
4-Chloro-5-aminopyrimidine
Packaging
500mg
Price
$360
Updated
2021/12/16
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5-AMINO-4-CHLOROPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

54851-35-3

54660-78-5

General procedure for the synthesis of 5-amino-4-chloropyrimidine from 5-amino-6-chloropyrimidine-4-thiol: The concentrated product of Example 18 (4.3 g, 26 mmol) was dissolved in EtOH (40 mL). Subsequently, NH4OH (4 mL) was added to this solution. Under stirring, an excess of Raney Nickel was added in batches. the reaction mixture was stirred overnight at room temperature and then heated at 80 °C for 2 h. The reaction was carried out at room temperature. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. The crude product was purified by silica fast chromatography using EtOAc/hexane as eluent to give 1.6 g (47% yield) of 5-amino-4-chloropyrimidine as a yellow solid.

References

[1] Patent: US2006/13799, 2006, A1. Location in patent: Page/Page column 59
[2] Patent: WO2006/127584, 2006, A1. Location in patent: Page/Page column 61; 89
[3] Patent: WO2007/8563, 2007, A2. Location in patent: Page/Page column 88

5-AMINO-4-CHLOROPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-4-CHLOROPYRIMIDINE Suppliers

Americas 1 China 118 Europe 2 Germany 4 India 2 Japan 1 United Kingdom 4 United States 30 Global 162
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
CHEMSTEP
Tel
--
Fax
--
Email
info@chemstep.com
Country
Europe
ProdList
6143
Advantage
51
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View Lastest Price from 5-AMINO-4-CHLOROPYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-chloropyrimidin-5-amine 54660-78-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Shaanxi Dideu Medichem Co. Ltd
Product
4-chloropyrimidin-5-amine 54660-78-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Career Henan Chemical Co
Product
5-AMINO-4-CHLOROPYRIMIDINE 54660-78-5
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

54660-78-5, 5-AMINO-4-CHLOROPYRIMIDINERelated Search:

2,4-Dichloro-5-nitropyrimidine 4,6-Dichloro-2-methyl-5-nitropyrimidine 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 2,4-Dichloro-6-methyl-5-nitropyrimidine 4,6-Dichloro-5-nitropyrimidine Moxonidine 2,5-Diamino-4,6-dichloropyrimidine 5-Amino-4,6-dichloropyrimidine 5-Amino-4,6-dichloro-2-methylpyrimidine 2,4,6-TRICHLORO-5-NITROPYRIMIDINE 2-AMINO-5-CHLOROPYRIMIDINE-4-CARBOXYLIC ACID 4-Amino-2-chloropyrimidine-5-carboxylic acid 4-Amino-6-chloropyrimidine-5-carboxaldehyde 2-AMINO-5-CHLOROPYRIMIDINE 4-Amino-2-chloropyrimidine-5-carbonitrile ,97%,4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE,4-AMINO-2-CHLOROPYRIMIDINE-5-CARBOXNITR& 5-Chloropyrimidine-2,4,6-triamine 4-Amino-6-chloro-2-methylpyrimidine 2-CHLORO-4-(N,N-DIMETHYLAMINO)PYRIMIDINE

  • 5-AMINO-4-CHLOROPYRIMIDINE
  • 5-PYRIMIDINAMINE, 4-CHLORO-
  • 5-Pyrimidinamine, 4-chloro- (9CI)
  • 4-chloropyriMidin-5-aMine
  • 4-Chloro-5-aMinopyriMidine
  • 4-chloro-pyriMidin-5-ylaMine
  • 4-Chloro-5-pyrimidinamine
  • Amino chloropyrimidine
  • 5-Amino-4-chloropyrimidine,96%
  • 54660-78-5
  • 54660-78-9
  • Heterocycle-Pyrimidine series
  • PYRIMIDINE