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2-Amino-4-cyanopyridine

Product Name
2-Amino-4-cyanopyridine
CAS No.
42182-27-4
Chemical Name
2-Amino-4-cyanopyridine
Synonyms
2-Aminoisonicotinonitrile;2-Amino-4-cyanopyrid;4-Cyano-2-pyridinamine;5-AMINO-4-CYANOPYRIDINE;2-AMINO-4-CYANOPYRIDINE;2-Amino-4-cyanopyridine,97%;2-aminopyridine-4-carbonitrile;2-Amino-4-pyridinecarbonitrile;4-PYRIDINECARBONITRILE, 2-AMINO-;2-Amino-4-cyanopyridine ISO 9001：2015 REACH
CBNumber
CB8402839
Molecular Formula
C6H5N3
Formula Weight
119.12
MOL File
42182-27-4.mol
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2-Amino-4-cyanopyridine Property

Melting point:
146-148°C
Boiling point:
297.7±20.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
3.93±0.11(Predicted)
Appearance
Off-white to light yellow Solid
Water Solubility 
Slightly soluble in water.
BRN 
386393
InChI
InChI=1S/C6H5N3/c7-4-5-1-2-9-6(8)3-5/h1-3H,(H2,8,9)
InChIKey
GEEAYLFEIFJFGP-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC(C#N)=C1
CAS DataBase Reference
42182-27-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38-41-37/38-22
Safety Statements 
26-36/37/39-36-39
RIDADR 
3439
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A3576
Product name
2-Aminoisonicotinonitrile
Purity
min. 98.0 %
Packaging
1G
Price
$63
Updated
2025/07/31
TCI Chemical
Product number
A3576
Product name
2-Aminoisonicotinonitrile
Purity
min. 98.0 %
Packaging
5G
Price
$189
Updated
2025/07/31
TRC
Product number
A603523
Product name
2-Amino-4-cyanopyridine
Packaging
10g
Price
$970
Updated
2021/12/16
Apolloscientific
Product number
OR6619
Product name
2-Aminoisonicotinonitrile
Packaging
1g
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-1-8Q
Product name
2-Aminoisonicotinonitrile
Packaging
1g
Price
$16
Updated
2021/12/16
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2-Amino-4-cyanopyridine Chemical Properties,Usage,Production

Chemical Properties

Yellow or pale brown cryst powder

Uses

2-Amino-4-cyanopyridine is used in the treatment of central nervous system (CNS) disorders and as a mGluR2 antagonist.

Uses

2-Amino-4-cyanopyridine is a pyridine derivative as mGluR2 antagonists; used in the treatment of CNS disorders.

Synthesis

557-21-1

84249-14-9

42182-27-4

Step 5: A mixture of 4-bromopyridin-2-amine (4.9 g, 28.5 mmol), zinc cyanide (5.0 g, 42.5 mmol), tris(dibenzylideneacetone)dipalladium (1.3 g, 1.4 mmol), and 1,1'-bis(diphenylphosphino)ferrocene (1.6 g, 2.8 mmol) was dissolved in N,N-dimethylformamide (150 mL). The reaction mixture was stirred at 100 °C for 1.5 h under nitrogen protection. After completion of the reaction, the mixture was cooled to room temperature and diluted with water (500 mL). The mixture was extracted with ethyl acetate (300 mL x 3). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent petroleum ether/ethyl acetate (10:1 to 2:1) to afford 2-amino-4-cyanopyridine as a light yellow solid (2.7 g, 80% yield).1H NMR (300 MHz, CDCl3) δ 8.19 (d, J = 5.1 Hz, 1H), 6.82 (d, J = 4.8 Hz, 1H) 6.69 (d, J = 0.9 Hz, 1H), 4.72 (br s, 2H).LCMS (ESI) m/z 120 (M + H)+.

References

[1] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 117.5

2-Amino-4-cyanopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4-cyanopyridine Suppliers

Canada 1 China 234 Europe 1 Germany 4 India 3 Jordan 1 Slovakia 1 Ukraine 1 United Kingdom 12 United States 30 Global 288
Georganics Ltd.
Tel
--
Fax
--
Email
georganics@nextra.sk
Country
Slovakia
ProdList
613
Advantage
50
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View Lastest Price from 2-Amino-4-cyanopyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Amino-4-cyanopyridine 42182-27-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-04
Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-4-cyanopyridine 42182-27-4
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Henan Aochuang Chemical Co.,Ltd.
Product
2-Amino-4-cyanopyridine 42182-27-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09

42182-27-4, 2-Amino-4-cyanopyridineRelated Search:

4-Methylpyridin-2-amine 4-Cyanopyridine ETHYL 2-CYANOACRYLATE Glycine ALTRENOGEST 2,6-Lutidine 2-Chloro-3-cyanopyridine 4-Dimethylaminopyridine 6-Aminocaproic acid 3-Cyanopyridine 3-Aminophenol 3-Aminopyridine 2-Aminopyridine Tris(hydroxymethyl)aminomethane 3-AMINO-4-CYANOPYRIDINE 2-Pyrimidinecarbonitrile, 5-amino- (9CI) 4-Amino-2-bromopyrimidine-5-carbonitrile N'-[6-(4-BROMOPHENYL)-3,4,5-TRICYANO-2-PYRIDINYL]-N,N-DIMETHYLIMINOFORMAMIDE

  • 4-PYRIDINECARBONITRILE, 2-AMINO-
  • 2-AMINO-4-CYANOPYRIDINE
  • 2-Aminoisonicotinonitrile
  • 4-Cyano-2-pyridinamine
  • 5-AMINO-4-CYANOPYRIDINE
  • 2-Amino-4-pyridinecarbonitrile
  • 2-aminopyridine-4-carbonitrile
  • 2-Amino-4-cyanopyrid
  • 2-Amino-4-cyanopyridine, 2-Aminopyridine-4-carbonitrile
  • 2-Amino-4-cyanopyridine,97%
  • 2-Amino-4-cyanopyridine ISO 9001：2015 REACH
  • 42182-27-4
  • Heterocycle-Pyridine series
  • Chemical Amines
  • Pyridine
  • Amines
  • Heterocycles
  • Pyridines
  • Pyridine series
  • pharmacetical
  • Pyridines, Pyrimidines, Purines and Pteredines