Benzhydrol

ChemicalBook > CAS DataBase List > Benzhydrol

Product Name: Benzhydrol
CAS No.: 91-01-0
Chemical Name: Benzhydrol
Synonyms: DIPHENYLMETHANOL;benzydrol;Benzhydryl alcohol;BENZOHYDROL;DIPHENYLCARBINOL;ALPHA-PHENYLBENZENEMETHANOL;NSC 32150;BENZHYDROL;BNEZHYDROL;Benzhydrol >
CBNumber: CB8417044
Molecular Formula: C13H12O
Formula Weight: 184.24
MOL File: 91-01-0.mol

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Benzhydrol Property

Melting point:: 65-67 °C (lit.)
Boiling point:: 297-298 °C (lit.)
Density: 1.0120 (rough estimate)
vapor pressure: 0.000076 hPa (20 °C)
refractive index: 1.5727 (estimate)
Flash point:: 160 °C
storage temp.: Store below +30°C.
solubility: 0.52g/l insoluble
form: Crystalline Solid
pka: 13.55±0.20(Predicted)
color: White to beige
Odor: at 100.00 %. weedy green rose
Odor Type: green
Water Solubility: Slightly soluble in water.
Merck: 14,1090
BRN: 1424379
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids.
LogP: 2.670
CAS DataBase Reference: 91-01-0(CAS DataBase Reference)
NIST Chemistry Reference: Benzenemethanol, «alpha»-phenyl-(91-01-0)
EPA Substance Registry System: Benzenemethanol, .alpha.-phenyl- (91-01-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 2
RTECS: DC7452000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29062900
Toxicity: LD50 orally in Rabbit: 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B4856
Product name: Diphenylmethanol
Purity: 99%
Packaging: 5g
Price: $34.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP1119
Product name: Diphenylmethanol
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 25MG
Price: $229
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1051602
Product name: Cyclizine impurity B
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: D0898
Product name: Benzhydrol
Purity: >99.0%(GC)
Packaging: 25g
Price: $18
Updated: 2024/03/01

TCI Chemical

Product number: D0898
Product name: Benzhydrol
Purity: >99.0%(GC)
Packaging: 500g
Price: $85
Updated: 2024/03/01

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Benzhydrol Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

Anchoring of carboxylic acids and alcohols

Uses

Benzhydrols are industrially important compounds. On oxidation Benzhydrols yields Benzophenone, which are useful synthones for fullerenes, bioactive oxygen heterocycles, dyes and medicines. Various Cr (VI) and other oxidizing agents are used for oxidizing benzhydrol.
Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group. It is used as precursor to prepare modafinil, benztropine and diphehydramine.
Intermediate in the preparation of Modafinil (M482500).

Definition

ChEBI: Diphenylmethanol is a secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1. It has a role as a rat metabolite, a bacterial xenobiotic metabolite, a human xenobiotic metabolite and a human urinary metabolite. It is a secondary alcohol and a member of benzyl alcohols. It derives from a hydride of a diphenylmethane.

Reactions

Benzhydrol is oxidized to benzophenone, by sodium hypochlorite (commonly known as bleach) in the presence of a phase-transfer catalyst.
Synthesis: In a 20-mL green capped vial, place 1.5 mL of ethyl acetate, 100 mg (0.54 mmol) of benzhydrol and a few drops of methyltricaprylammonium chloride solution (Stark's catalyst or tricaprylmethylammonium chloride). Add a half-inch magnetic stirring bar, and stir until all reagents are dissolved. Cool the solution in an ice bath and add 2 mL of 5% NaOCl (aq) (bleach) dropwise using a 2.5- mL syringe. After the addition of the hypochlorite is complete, allow the reaction to stir for five minutes in the ice-water bath and then stir for a period of one hour at room temperature.

Reduction of benzophenone to benzhydrol.
4MPDC (4-Methyl pyridinium di chromate) is used as oxidizing agent to oxidize benzhydrol. PDC is a mild and selective oxidizing agent and is soluble in water and many organic solvents. Therefore, advantage over inorganic dichromate.

Synthesis Reference(s)

Canadian Journal of Chemistry, 50, p. 3058, 1972 DOI: 10.1139/v72-485
Journal of the American Chemical Society, 55, p. 391, 1933 DOI: 10.1021/ja01328a057
Tetrahedron Letters, 29, p. 139, 1988 DOI: 10.1016/S0040-4039(00)80036-2

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Purification Methods

Crystallise benzhydrol from hot H2O or pet ether (b 60-70o), pet ether containing a little *benzene, from CCl4, or EtOH (1mL/g). An additional purification step includes passage of a *benzene solution through an activated alumina column. It sublimes in a vacuum. Also recrystallise it three times from MeOH/H2O [Naguib J Am Chem Soc 108 128 1986]. [Beilstein 6 IV 4648.]

Benzhydrol Preparation Products And Raw materials

Raw materials

ZINC Benzophenone

Preparation Products

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene ERIO GREEN B CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL 1-BENZHYDRYLPIPERAZINE Indigo Carmine 2-Chlorotrityl chloride

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View Lastest Price from Benzhydrol manufacturers

Jinan Finer Chemical Co., Ltd

Product: Benzhydrol 91-01-0
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000mt/year
Release date: 2021-06-22

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Benzhydrol 91-01-0
Price: US $40.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200000kg
Release date: 2024-04-25

Guangzhou PI PI BIOTECH INC

Product: Sulbactam Impurity 1 91-01-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2021-07-11

91-01-0, BenzhydrolRelated Search:

Benzyl alcohol Diphenylsilanediol 4'-tert-Butyl-4-chlorobutyrophenone 4'-tert-Butylacetophenone 4',5'-DIBROMOFLUORESCEIN Benzilic acid Methyl benzilate 4,4'-Dichlorobenzhydrol 1,1,3-Triphenylpropargyl alcohol 2',7'-Dichlorofluorescein ALPHA-NAPHTHOLBENZEIN o-Methyl benzhydrol TETRAIODOPHENOLPHTHALEIN DIBENZOSUBERENOL Benzhydrol, 4-chloro-,Benzhydrol, p-chloro-,P-CHLORO BENZHYDROL 4,4'-Difluorobenzhydrol ERYTHROSIN B Triphenylmethanol

ALPHA-PHENYLBENZENEMETHANOL

BENZHYDROL

BENZOHYDROL

DIPHENYLCARBINOL

DIPHENYLMETHANOL

HYDROXYDIPHENYL METHANE

Benzenemethanol,alpha-phenyl-

Benzhydryl alcohol

alpha-phenyl-benzenemethano

a-Phenylbenzenemethanol

a-Phenylbenzyl alcohol

DIPHENYLCARBINOL(BENZHYDROL)

PARA-HYDROXYDIPHENYLMETHANE

Benzhydrylalkohol

BNEZHYDROL

DIPHENYCARBINOL pure

Benzhydryl alcoho

Diphenylmethanol,Benzhydrol, Diphenyl carbinol

NSC 32150

α-Phenylbenzyl Alcohol

Diphenylcarbinol Diphenylmethanol

BENZHYDROL FOR SYNTHESIS 250 G

BENZHYDROL FOR SYNTHESIS 1 KG

Benzhydrol, 99% 100GR

Twophenyl carbinol

Benzhydrol (50 mg)

Diphenylmethanol, >=99%

DiphenylMethanol 99%

Benzhydrol for synthesis

Diphenhydramine EP impurity D

Ebastine Impurity 1(EP Impurity A)

4-Methyl-&alpha

Dimenhydrinate EP Impurity I

diphenyl-(2-pyridin-4-ylcyclopropyl)methanol

3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-&alpha

Benzhydrol,(Diphenylcarbinol

Trichlorethyl Benzoquinone

BENZHYDROL 99%

BENZHYDROL 99+%

benzhydrylalcohol

benzydrol

Diphenylmethyl alcohol

diphenylmethylalcohol

α-phenylbenzenemethanol

Dimenhydrinate EP Impurity D(Benzyhydrol)

Diphenhydramine Impurity 4（Diphenhydramine EP Impurity D）

Benzhydrol &gt

Cyclizine impurity B CRS

Dimenhydrinate EP Impurity I (Benzhydrol)

Benzenemethanol, α-phenyl-

Dimenhydrinate Impurity 9 (Dimenhydrinate EP Impurity I)

Diphenhydramine EP Impurity D (Diphenylmethanol/ Benzhydrol)

Cyclizine impurity B (Y0000887)

Diphenhydramine Impurity D

Diphenylcarbinol pure, 99%

Dimenhydrinate Impurity I

Diphenhydramine EP Impurity D（Dimenhydrinate EP Impurity I/Ebastine EP Impurity A）

Cyclizine Hydrochloride Impurity B