Description Reference
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2-Amino-4-chloro-3-nitropyridine

Description Reference
Product Name
2-Amino-4-chloro-3-nitropyridine
CAS No.
6980-08-1
Chemical Name
2-Amino-4-chloro-3-nitropyridine
Synonyms
4-Chloro-3-nitropyridin-2-amine;0/1/80;2-AMINO-4-CHLORO-3-NITROPYRIDINE;2-PyridinaMine, 4-chloro-3-nitro-;4-Chloro-3-nitro-pyridin-2-ylaMine;2-AMINO-4-CHLORO-3-NITROPYRIDINE 98%;2-Amino-4-chloro-3-nitropyridine ISO 9001：2015 REACH
CBNumber
CB8445690
Molecular Formula
C5H4ClN3O2
Formula Weight
173.56
MOL File
6980-08-1.mol
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2-Amino-4-chloro-3-nitropyridine Property

Melting point:
174-176°C
Boiling point:
329.0±37.0 °C(Predicted)
Density 
1.596±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in dimethyl formamide, dimethyl sulfoxide, hot ethanol, ethyl acetate and hot methanol.
pka
1.31±0.47(Predicted)
form 
Solid
color 
Yellow
InChI
InChI=1S/C5H4ClN3O2/c6-3-1-2-8-5(7)4(3)9(10)11/h1-2H,(H2,7,8)
InChIKey
DIRINUVNYFAWQF-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC(Cl)=C1[N+]([O-])=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
A603485
Product name
2-Amino-4-chloro-3-nitropyridine
Packaging
50mg
Price
$105
Updated
2021/12/16
Usbiological
Product number
A1376-52
Product name
2-Amino-4-chloro-3-nitropyridine
Packaging
100mg
Price
$460
Updated
2021/12/16
AK Scientific
Product number
J94240
Product name
2-Amino-3-nitro-4-chloropyridine
Packaging
100g
Price
$600
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011045
Product name
2-AMINO-4-CHLORO-3-NITROPYRIDINE
Purity
95.00%
Packaging
100MG
Price
$750.75
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
6440
Product name
2-Amino-4-chloro-3-nitropyridine
Packaging
100mg
Price
$900
Updated
2021/12/16
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2-Amino-4-chloro-3-nitropyridine Chemical Properties,Usage,Production

Description

It is usually used as the intermediate or raw material in organic synthesis and pharmaceutical industry. Specifically, this chemical can act as the intermediate in the synthesis of 5-amino-azaoxindole derivatives.1 Moreover, this substance may be involved in the preparation of pharmaceutically active compounds that can be used in the treatment of proliferative disorders, as well as other diseases or conditions in which aurora kinase and/or FLT3 activity is implicated.2 In addition, this chemical has been demonstrated to function as the intermediate in the synthesis of 1-deaza-6-methylthiopurine ribonucleoside, which is proved to exhibit cytotoxicty.3 Besides, 2-amino-4-chloro-3-nitropyridine can be utilized to fabricate central nervous system (CNS) active compounds.4

Reference

  1. Tzvetkov, N. T.; Muller, C. E., Facile synthesis of 5-aminoand 7-amino-6-azaoxindole derivatives. Tetrahedron Lett. 2012, 53, 5597-5601.
  2. Julian Blagg; Bavetsias; Moore; Linardopoulos, pharmaceutically active compounds. US Patent US 9447092 B2 2016.
  3. JMontgomery, J. A.; Hewson, K., 1-DEAZA-6-METHYLTHIOPURINE RIBONUCLEOSIDE. J. Med. Chem. 1966, 9, 354-+.
  4. JHarry Louis Yale; Sheehan, J. T., CNS active compounds US Patent 4022897 1977.

Chemical Properties

Bright Yellow Needles

Uses

2-Amino-4-chloro-3-nitropyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis

19798-80-2

6980-08-1

4-Chloro-2-aminopyridine (6.4 g, 50 mmol) was slowly added dropwise to fuming nitric acid (50 mL) under ice bath cooling conditions. The reaction mixture was gradually warmed to room temperature and then poured into water containing crushed ice to quench the reaction. The precipitate was collected by filtration and purified by fast column chromatography (eluent: dichloromethane/methanol = 100:1, v/v) to afford 2-amino-3-nitro-4-chloropyridine as a white solid (7.4 g, 85% yield).

References

[1] Patent: CN106146504, 2016, A. Location in patent: Paragraph 0168; 0169; 0170; 0171; 0172
[2] Patent: KR101556826, 2015, B1. Location in patent: Paragraph 0065-0067
[3] ChemMedChem, 2012, vol. 7, # 6, p. 1057 - 1070
[4] Patent: US2008/51404, 2008, A1. Location in patent: Page/Page column 110
[5] Patent: US2016/96834, 2016, A1. Location in patent: Paragraph 0244

2-Amino-4-chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4-chloro-3-nitropyridine Suppliers

Canada 1 China 161 Germany 4 India 10 Slovakia 1 United Kingdom 2 United States 13 Global 192
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 2-Amino-4-chloro-3-nitropyridine manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Amino-4-chloro-3-nitropyridine 6980-08-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Shaanxi Dideu Medichem Co. Ltd
Product
2-AMino-4-chloro-3-nitropyridine 6980-08-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2019-12-27
Dideu Industries Group Limited
Product
2-Amino-4-chloro-3-nitropyridine 6980-08-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-03

6980-08-1, 2-Amino-4-chloro-3-nitropyridineRelated Search:

2-Aminopyridine Clopidol 2,3,5,6-Tetrachloropyridine 2-Amino-3-nitropyridine Glycine 3-Aminopyridine 4-Dimethylaminopyridine ALTRENOGEST Difluorochloromethane 2-AMINO-4-CHLORO-5-NITROPYRIDINE 2-AMINO-3-CHLORO-5-NITROPYRIDINE,2-AMINO-3-CHLORO-5-NITROPYRIDINE, 95+% 2-Methylamino-3-nitro-6-chloropyridine 2-Amino-6-chloro-3-nitropyridine 98%,6-Amino-2-chloro-5-nitropyridine,2-AMINO-6-CHLORO-3-NITROPYRIDINE 2-AMINO-5-CHLORO-3-NITROPYRIDINE,2-AMINO-5-CHLORO-3-NITROPYRIDINE 98+% GC,2-AMINO-5-CHLORO-3-NITROPYRIDINE, 98+% 2-AMINO-5-CHLORO-3-NITROPYRIDINE 4-AMINO-2-CHLORO-3-NITROPYRIDINE 3-Amino-2-chloro-4-nitropyridine (4-Chloro-3-nitro-pyridin-2-yl)-methyl-amine

  • 2-AMINO-4-CHLORO-3-NITROPYRIDINE
  • 4-Chloro-3-nitropyridin-2-amine
  • 4-Chloro-3-nitro-pyridin-2-ylaMine
  • 2-PyridinaMine, 4-chloro-3-nitro-
  • 2-Amino-4-chloro-3-nitropyridine ISO 9001：2015 REACH
  • 0/1/80
  • 2-AMINO-4-CHLORO-3-NITROPYRIDINE 98%
  • 6980-08-1
  • 8/1/6980
  • 6980-8-1
  • 6980-08-6
  • 6980/8/1
  • 6980-80-1
  • 60.980-08-1
  • Heterocycle-Pyridine series
  • Amines
  • Aromatics
  • Heterocycles
  • Pyridines
  • Nucleotides and Nucleosides
  • Bases & Related Reagents
  • Nucleotides
  • API intermediates