3-Bromothiophene-2-carboxylic acid

Product Name: 3-Bromothiophene-2-carboxylic acid
CAS No.: 7311-64-0
Chemical Name: 3-Bromothiophene-2-carboxylic acid
Synonyms: 3-Bromothiophene-2-carboxylic acid ,98%;THCOOH-Br;BUTTPARK 97\04-30;RARECHEM AL BO 2385;3-Bromothiophene-2-c;3-Bromothiophene-2-carboxyL;3-BROMOTHIOPHENE-2-CARBOXYLIC ACID;3-BROMO-2-THIOPHENECARBOXYLIC ACID;3-BroMothiophene-2-carboxylic acid3;2-Thiophenecarboxylicacid, 3-bromo-
CBNumber: CB8483698
Molecular Formula: C5H3BrO2S
Formula Weight: 207.05
MOL File: 7311-64-0.mol

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3-Bromothiophene-2-carboxylic acid Property

Melting point:: 197-201 °C(lit.)
Boiling point:: 318.0±27.0 °C(Predicted)
Density: 1.923±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 3.09±0.10(Predicted)
color: White to Almost white
BRN: 121585
CAS DataBase Reference: 7311-64-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 43-36/37/38
Safety Statements: 36/37-37/39-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 633011
Product name: 3-Bromothiophene-2-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $29
Updated: 2023/06/20

Sigma-Aldrich

Product number: 633011
Product name: 3-Bromothiophene-2-carboxylic acid
Purity: 97%
Packaging: 25g
Price: $129
Updated: 2023/06/20

TCI Chemical

Product number: B4605
Product name: 3-Bromothiophene-2-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: B4605
Product name: 3-Bromothiophene-2-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $70
Updated: 2025/07/31

TRC

Product number: B698990
Product name: 3-Bromothiophene-2-carboxylic Acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

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3-Bromothiophene-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Synthesis

3140-93-0

124-38-9

7311-64-0

Under nitrogen protection, 2,3-dibromothiophene (12.1 g, 0.025 mol) was dissolved in anhydrous ether (15 mL) and cooled to -78°C. A solution of n-butyllithium (2.5 M, 22 mL, 0.055 mol) in ether was slowly added dropwise. After the dropwise addition, stirring was continued at -78 °C for 10 minutes. Subsequently, gaseous carbon dioxide was passed into the reaction system and a white precipitate was immediately observed to form. After keeping the reaction at -78 °C for 30 min, the reaction was slowly warmed up to room temperature. Upon completion of the reaction, the reaction was quenched with Milli-Q water and the aqueous phase was extracted with 10% sodium hydroxide solution (3 x 50 mL). The aqueous phase was combined, acidified with 6 N hydrochloric acid and the precipitate precipitated was collected by filtration. The resulting solid was recrystallized with ethanol (50 mL) and water (200 mL) and dried in vacuum to give the white powdery product 3-bromothiophene-2-carboxylic acid (9.23 g). The product was analyzed by 19F NMR, mass spectrometry (70 eV, EI): m/z 208 (M-1), 1H NMR (CDCl3): δ 7.81 (d, 1H, J=5.2 Hz), 7.19 (d, 1H, J=5.2 Hz) and 13C NMR (CDCl3): δ 117.6, 133.8, 134.6, 162.6, 207.6 Confirmed structure.

References

[1] Chemical Communications, 2011, vol. 47, # 43, p. 11840 - 11842
[2] Patent: WO2012/156948, 2012, A1. Location in patent: Page/Page column 21-22
[3] Synthesis, 1980, # 4, p. 327 - 329
[4] Archiv der Pharmazie, 1998, vol. 331, # 12, p. 405 - 411

3-Bromothiophene-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Sodium hypochlorite Sodium sulfate Sodium chloride Acetyl chloride Aluminum chloride 3-Bromothiophene Ethyl acetate Sodium bicarbonate Dichloromethane PETROLEUM ETHER

Preparation Products

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View Lastest Price from 3-Bromothiophene-2-carboxylic acid manufacturers

R&D Scientific Inc.

Product: 3-Bromothiophene-2-carboxylic acid 7311-64-0
Price: US $560.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-02-19

Career Henan Chemical Co

Product: 3-Bromothiophene-2-carboxylic acid 7311-64-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

7311-64-0, 3-Bromothiophene-2-carboxylic acidRelated Search:

3-Thiophenemalonic acid 3-Bromothiophene Methyl 2-bromobenzoate 3,5-Dihydroxybenzoic acid 4-Bromobenzoic acid Ethyl 2-(Chlorosulfonyl)acetate Methyl 4-(bromomethyl)benzoate Folic acid Tetrahydrothiophene Cephalothin sodium METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID Ethyl 5-bromothiophene-2-carboxylate Methyl 4-bromothiophene-2-carboxylate 5-BROMOTHIOPHENE-2-CARBOXYLIC ACID METHYL4,5-DIBROMOTHIOPHENE-2-CARBOXYLATE 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID 4-Bromo-2-thiophenecarboxylic acid

2-Thiophenecarboxylicacid, 3-bromo-

THCOOH-Br

3-Bromothiophene-2-carboxyL

BUTTPARK 97\04-30

RARECHEM AL BO 2385

3-BROMO-2-THIOPHENECARBOXYLIC ACID

3-BROMOTHIOPHENE-2-CARBOXYLIC ACID

3-Bromothiophene-2-carboxylic acid ,98%

3-Bromothiophene-2-carboxylic acid 98%

3-Bromothiophene-2-c

3-BroMothiophene-2-carboxylic acid3

3-Bromothiophene-2-carboxylic Acid &gt

3-Bromothiophene-2-carboxylic acid ISO 9001：2015 REACH

7311-64-0

C5H2BrO2S

Building Blocks

Thiophenes

Halogenated Heterocycles

Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

C4 to C6

Chemical Synthesis

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Carboxylic Acids

Thiophenes & Benzothiophenes

Carboxylic Acids

Thiophenes & Benzothiophenes

Halogenated Heterocycles

Heterocyclic Building Blocks

Thiophenes

ThiophenesBuilding Blocks