SU 5416
- Product Name
- SU 5416
- CAS No.
- 204005-46-9
- Chemical Name
- SU 5416
- Synonyms
- 17022;SU54161;SeMaxinib;(Z)-3-((3;Sugen 5416;SU5416 /SU-5416;SU 5416 semaxanib;SEMAXINIB(SU 5416);SU 5416 (SeMaxinib);SEMAXINIB; SU-5416; SU 5416
- CBNumber
- CB8504771
- Molecular Formula
- C15H14N2O
- Formula Weight
- 238.28
- MOL File
- 204005-46-9.mol
SU 5416 Property
- Melting point:
- 226-228 °C
- Boiling point:
- 481.4±45.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- H2O: insoluble
- form
- Yellow orange solid
- pka
- 12.59±0.20(Predicted)
- color
- yellow to yellow orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- S8442
- Product name
- SU 5416
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $162
- Updated
- 2024/03/01
- Product number
- 13342
- Product name
- SU 5416
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- S8442
- Product name
- SU 5416
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $560
- Updated
- 2024/03/01
- Product number
- 13342
- Product name
- SU 5416
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- 13342
- Product name
- SU 5416
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $547
- Updated
- 2024/03/01
SU 5416 Chemical Properties,Usage,Production
Uses
SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.
Uses
SU 516 was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain.3 It was used to study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension.4
Definition
ChEBI: Semaxanib is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an angiogenesis modulating agent. It is a member of pyrroles, a member of oxindoles and an olefinic compound. It is functionally related to a 3-methyleneoxindole.
Biological Activity
Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.
Biochem/physiol Actions
SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.1 It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.2
storage
Desiccate at -20°C
SU 5416 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SU 5416 manufacturers
- Product
- SU 5416 204005-46-9
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03