Alfuzosin hydrochloride
- Product Name
- Alfuzosin hydrochloride
- CAS No.
- 81403-68-1
- Chemical Name
- Alfuzosin hydrochloride
- Synonyms
- URION;XATRAL;Alfoten;MITTOVAL;Uroxatral;UROXANTRAL;Udon：xatral;SL-77,499-10;ALFUZOSIN HCL;Alfuzosin-d7 HCl
- CBNumber
- CB8703590
- Molecular Formula
- C19H28ClN5O4
- Formula Weight
- 425.91
- MOL File
- 81403-68-1.mol
Alfuzosin hydrochloride Property
- Melting point:
- 225°C
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- pka
- 8.13(at 25℃)
- form
- solid
- color
- White to Off-White
- Merck
- 14,238
- InChI
- InChI=1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H
- InChIKey
- YTNKWDJILNVLGX-UHFFFAOYSA-N
- SMILES
- C12=C(N)N=C(N(C)CCCNC(=O)C3OCCC3)N=C1C=C(OC)C(OC)=C2.Cl
- CAS DataBase Reference
- 81403-68-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0001906
- Product name
- Alfuzosin for system suitability A
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 10 mg
- Price
- $164
- Updated
- 2025/07/31
- Product number
- Y0001883
- Product name
- Alfuzosin for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 10 mg
- Price
- $216
- Updated
- 2025/07/31
- Product number
- Y0000832
- Product name
- Alfuzosin for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 1 unit
- Price
- $208
- Updated
- 2025/07/31
- Product number
- BP847
- Product name
- Alfuzosin impurity standard
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 25MG
- Price
- $248
- Updated
- 2025/07/31
- Product number
- BP825
- Product name
- Alfuzosin hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $240
- Updated
- 2025/07/31
Alfuzosin hydrochloride Chemical Properties,Usage,Production
Description
Alfuzosin (SL-77499) (I), a quinazoline derivative which is a uroselective alpha-1 adrenoreceptor antagonist, has been developed and launched worldwide by Sanofi-Synthelabo, for the treatment of benign prostate hyperplasia (BPH). In November 2003, alfuzosin (I) was launched as an extended release formulation in the US as Uroxatral utilizing Skyepharma’s oral controlled release technology.
Chemical Properties
White to Off-White Solid
Uses
a-1- Adrenoceptor antagonist structurally similar to prozosin
Uses
Antihypertensor;Alpha 1- adrenergic antagonist
Uses
α1-Adrenoceptor antagonist structurally similar to Prozosin. Antihypertensive. Alfuzosin hydrochloride is used in treatment of benign prostatic hypertrophy.
brand name
Uroxatral (Sanofi Aventis).
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biological Activity
Functionally uro-selective α 1 adrenoceptor antagonist that does not discriminate between α 1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC 50 = 7.64) in vitro .
Biochem/physiol Actions
Alfuzosin hydrochloride is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
Clinical Use
Alpha-blocker:
Treatment of benign prostatic hyperplasia
Treatment of acute urinary retention
Synthesis
Although syntheses of alfuzosin (I) have appeared in several reports, an optimized route used for the manufacture of the compound does not appear in the literature. The synthesis reported by the Sanofi group for alfuzosin will be described and is shown in the scheme. The commercially available 4- amino-2-chloro-6,7-dimethoxyquinazoline (1) was treated with 3-methylaminopropionitrile (2) in isoamyl alcohol and refluxed for 5 hrs. Filtration of the precipitated product and washing with ethanol gave nitrile 3 in 62% yield. Hydrogenation of the nitrile was done in 15% ammonia solution in ethanol with Raney nickel as catalyst at 70??C and 1000 psi to obtain the corresponding amine free base. Conversion of the free base to the hydrochloride salt was done in ethanol to give the HCl salt 4 in 52% yield. The final acylation of amine 4 was done with the imidazolyl anhydride of furan 5. Thus, 2-carboxyfuran was treated with carbonyldiimidazole in THF at 40??C for 1 hr and then cooled to 10??C. Addition of amine 4 in THF in the presence of triethylamine at 10??C, then refluxing the reaction for 1 hr, and aqueous workup gave the alfuzosin free base. After conversion to the hydrochloride salt and recrystallization from 2-propanol alfuzosin hydrochloride (I) was obtained in 44% yield.
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: enhanced hypotensive effect with
MAOIs.
Antivirals: concentration possibly increased by
ritonavir - avoid; avoid with telaprevir.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced
hypotensive effect, separate administration by 4-6
hours.
Beta-blockers: enhanced hypotensive effect;
increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive
effect; increased risk of first dose hypotensive effect.
Cobicistat: concentration of alfuzosin possibly
increased - avoid.
Diuretics: enhanced hypotensive effect; increased
risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension.
Metabolism
Extensively metabolised in the liver, mainly by the cytochrome P450 isoenzyme CYP3A4, to inactive metabolites that are mainly excreted in faeces via the bile.
References
[1] Patent: WO2008/84493, 2008, A2. Location in patent: Page/Page column 9-10
[2] Patent: US2007/105880, 2007, A1. Location in patent: Page/Page column 6-8
[3] Patent: WO2006/90268, 2006, A2. Location in patent: Page/Page column 31-32
[4] Patent: WO2006/90268, 2006, A2. Location in patent: Page/Page column 33-34
[5] Patent: WO2006/90268, 2006, A2. Location in patent: Page/Page column 32
Alfuzosin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Alfuzosin hydrochloride Suppliers
- Tel
- --
- Fax
- --
- individualshareholders@sanofi.com
- Country
- France
- ProdList
- 43
- Advantage
- 58
- Tel
- --
- Fax
- --
- guedj.gregory@kleos-pharma.com
- Country
- France
- ProdList
- 298
- Advantage
- 58
- Tel
- --
- Fax
- --
- hepartex@hepartex.com
- Country
- France
- ProdList
- 199
- Advantage
- 58
- Tel
- --
- Fax
- --
- ex. janedoe@fareva.com
- Country
- France
- ProdList
- 29
- Advantage
- 58
- Tel
- --
- Fax
- --
- orders@edqm.eu
- Country
- France
- ProdList
- 1913
- Advantage
- 81
View Lastest Price from Alfuzosin hydrochloride manufacturers
- Product
- Alfuzosin hydrochloride 81403-68-1
- Price
- US $0.00/Kg/Bag
- Min. Order
- 10g
- Purity
- 99%-101%;EP
- Supply Ability
- 10KGS
- Release date
- 2021-07-19
- Product
- Alfuzosin hydrochloride 81403-68-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-12-09
- Product
- Alfuzosin hydrochloride 81403-68-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-11