ChemicalBook > CAS DataBase List > 2-(Trifluoromethyl)pyridine

2-(Trifluoromethyl)pyridine

Product Name: 2-(Trifluoromethyl)pyridine
CAS No.: 368-48-9
Chemical Name: 2-(Trifluoromethyl)pyridine
Synonyms: 2-(CF3)-Pyridine;α,α,α-trifluoro-2-picoline;à,à,à-trifluoro-2-picoline;2-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-(trifluoromethyl)-;2-(TrifluoroMethyl)pyridine, 95+%;2-trifluoromethylpyridine UNDRE RD;ALPHA,ALPHA,ALPHA-TRIFLUORO-2-PICOLINE;2-(Trifluoromethyl)pyridine ISO 9001：2015 REACH;2-(Trifluoromethyl)pyridine,α,α,α-Trifluoro-2-picoline
CBNumber: CB8727190
Molecular Formula: C6H4F3N
Formula Weight: 147.1
MOL File: 368-48-9.mol

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2-(Trifluoromethyl)pyridine Property

Boiling point:: 139-141 °C
Density: 1.275 g/mL at 25 °C
refractive index: n20/D 1.419
Flash point:: 109 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in most organic solvents.
pka: 0.60±0.12(Predicted)
form: clear liquid
color: Colorless to Light yellow
BRN: 3112
InChI: InChI=1S/C6H4F3N/c7-6(8,9)5-3-1-2-4-10-5/h1-4H
InChIKey: ATRQECRSCHYSNP-UHFFFAOYSA-N
SMILES: C1(C(F)(F)F)=NC=CC=C1
CAS DataBase Reference: 368-48-9(CAS DataBase Reference)
NIST Chemistry Reference: 2-(CF3)-pyridine(368-48-9)

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Safety

Hazard Codes: Xi,F
Risk Statements: 10-36/37/38
Safety Statements: 16-26-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Flammable/Irritant
HazardClass: 3
PackingGroup: III
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 643572
Product name: 2-(Trifluoromethyl)pyridine
Purity: 97%
Packaging: 1g
Price: $22
Updated: 2023/06/20

Sigma-Aldrich

Product number: 643572
Product name: 2-(Trifluoromethyl)pyridine
Purity: 97%
Packaging: 5g
Price: $58.7
Updated: 2023/06/20

TCI Chemical

Product number: T2683
Product name: 2-(Trifluoromethyl)pyridine
Packaging: 1G
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: T2683
Product name: 2-(Trifluoromethyl)pyridine
Packaging: 5G
Price: $76
Updated: 2025/07/31

TRC

Product number: T898723
Product name: 2-(Trifluoromethyl)pyridine
Packaging: 1g
Price: $45
Updated: 2021/12/16

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2-(Trifluoromethyl)pyridine Chemical Properties,Usage,Production

Uses

Lithiation with n-BuLi/LiOCH2CH2NMe2?takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP?. It is a building block in heterocycle synthesis.

Synthesis Reference(s)

Synthesis, p. 932, 1980 DOI: 10.1055/s-1980-29276

Synthesis

109-04-6

81290-20-2

368-48-9

AgF (1.27 g, 10 mmol) was dissolved in 10 mL of DMF at room temperature and stirred thoroughly. Subsequently, Me3SiCF3 (1.7 g, 12 mmol) was added to the mixture and stirring was continued for 20 minutes. Next, copper powder (1.0 g, 15 mmol) was added and the reaction mixture was stirred for 4 hours to ensure complete formation of CuCF3. Then, the corresponding halogenated compound (9 mmol, 4.5 mmol for 2,6-dibromopyridine) was added and the reaction mixture continued to be stirred under the conditions listed in Table 1. The progress of the reaction was monitored by 19F NMR spectroscopy until the signal of CuCF3 completely disappeared and the reaction was terminated. Upon completion of the reaction, the mixture was filtered to remove the solid precipitate and the filtrate was poured into 50 mL of water. The organic layer in the aqueous phase was extracted with ether and the extract was dried with MgSO4. Finally, the ether was removed by evaporation and the residue was purified by distillation under reduced pressure or crystallization to give the target product 2-trifluoromethylpyridine.

References

[1] Journal of Fluorine Chemistry, 2012, vol. 133, p. 67 - 71

2-(Trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE

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View Lastest Price from 2-(Trifluoromethyl)pyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-(Trifluoromethyl)pyridine 368-48-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Henan Fengda Chemical Co., Ltd

Product: 2-(Trifluoromethyl)pyridine 368-48-9
Price: US $32.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-22

Dideu Industries Group Limited

Product: 2-(Trifluoromethyl)pyridine 368-48-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-26

368-48-9, 2-(Trifluoromethyl)pyridineRelated Search:

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Pyridine, 2-(trifluoromethyl)-

ALPHA,ALPHA,ALPHA-TRIFLUORO-2-PICOLINE

à,à,à-trifluoro-2-picoline

α,α,α-trifluoro-2-picoline

2-(TRIFLUOROMETHYL)PYRIDINE

2-(Trifluoromethyl)pyridine,α,α,α-Trifluoro-2-picoline

2-trifluoromethylpyridine UNDRE RD

2-(CF3)-Pyridine

2-(TrifluoroMethyl)pyridine, 95+%

2-(Trifluoromethyl)pyridine ISO 9001：2015 REACH

368-48-9

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