2-(Trifluoromethyl)pyridine
- Product Name
- 2-(Trifluoromethyl)pyridine
- CAS No.
- 368-48-9
- Chemical Name
- 2-(Trifluoromethyl)pyridine
- Synonyms
- 2-(CF3)-Pyridine;α,α,α-trifluoro-2-picoline;à,à,à-trifluoro-2-picoline;2-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-(trifluoromethyl)-;2-(TrifluoroMethyl)pyridine, 95+%;2-trifluoromethylpyridine UNDRE RD;ALPHA,ALPHA,ALPHA-TRIFLUORO-2-PICOLINE;2-(Trifluoromethyl)pyridine ISO 9001：2015 REACH;2-(Trifluoromethyl)pyridine,α,α,α-Trifluoro-2-picoline
- CBNumber
- CB8727190
- Molecular Formula
- C6H4F3N
- Formula Weight
- 147.1
- MOL File
- 368-48-9.mol
2-(Trifluoromethyl)pyridine Property
- Boiling point:
- 139-141 °C
- Density
- 1.275 g/mL at 25 °C
- refractive index
- n20/D 1.419
- Flash point:
- 109 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in most organic solvents.
- pka
- 0.60±0.12(Predicted)
- form
- clear liquid
- color
- Colorless to Light yellow
- BRN
- 3112
- InChI
- InChI=1S/C6H4F3N/c7-6(8,9)5-3-1-2-4-10-5/h1-4H
- InChIKey
- ATRQECRSCHYSNP-UHFFFAOYSA-N
- SMILES
- C1(C(F)(F)F)=NC=CC=C1
- CAS DataBase Reference
- 368-48-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-(CF3)-pyridine(368-48-9)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Flammable/Irritant
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 643572
- Product name
- 2-(Trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $22
- Updated
- 2023/06/20
- Product number
- 643572
- Product name
- 2-(Trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $58.7
- Updated
- 2023/06/20
- Product number
- T2683
- Product name
- 2-(Trifluoromethyl)pyridine
- Packaging
- 1G
- Price
- $20
- Updated
- 2025/07/31
- Product number
- T2683
- Product name
- 2-(Trifluoromethyl)pyridine
- Packaging
- 5G
- Price
- $76
- Updated
- 2025/07/31
- Product number
- T898723
- Product name
- 2-(Trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
2-(Trifluoromethyl)pyridine Chemical Properties,Usage,Production
Uses
Lithiation with n-BuLi/LiOCH2CH2NMe2?takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP?. It is a building block in heterocycle synthesis.
Synthesis Reference(s)
Synthesis, p. 932, 1980 DOI: 10.1055/s-1980-29276
Synthesis
109-04-6
81290-20-2
368-48-9
AgF (1.27 g, 10 mmol) was dissolved in 10 mL of DMF at room temperature and stirred thoroughly. Subsequently, Me3SiCF3 (1.7 g, 12 mmol) was added to the mixture and stirring was continued for 20 minutes. Next, copper powder (1.0 g, 15 mmol) was added and the reaction mixture was stirred for 4 hours to ensure complete formation of CuCF3. Then, the corresponding halogenated compound (9 mmol, 4.5 mmol for 2,6-dibromopyridine) was added and the reaction mixture continued to be stirred under the conditions listed in Table 1. The progress of the reaction was monitored by 19F NMR spectroscopy until the signal of CuCF3 completely disappeared and the reaction was terminated. Upon completion of the reaction, the mixture was filtered to remove the solid precipitate and the filtrate was poured into 50 mL of water. The organic layer in the aqueous phase was extracted with ether and the extract was dried with MgSO4. Finally, the ether was removed by evaporation and the residue was purified by distillation under reduced pressure or crystallization to give the target product 2-trifluoromethylpyridine.
References
[1] Journal of Fluorine Chemistry, 2012, vol. 133, p. 67 - 71
2-(Trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Trifluoromethyl)pyridine manufacturers
- Product
- 2-(Trifluoromethyl)pyridine 368-48-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- 2-(Trifluoromethyl)pyridine 368-48-9
- Price
- US $32.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-22
- Product
- 2-(Trifluoromethyl)pyridine 368-48-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26