ChemicalBook > CAS DataBase List > AG 1478

AG 1478

Product Name
AG 1478
CAS No.
175178-82-2
Chemical Name
AG 1478
Synonyms
AG 1517;AG 1478;SU 5271;WHI-P 79;NSC 669364;PD-153,035;COMPOUND 32;Tyrphostin AG;AG 1478 USP/EP/BP;TYRPHOSTIN AG 1517
CBNumber
CB8751920
Molecular Formula
C16H14ClN3O2
Formula Weight
315.75
MOL File
175178-82-2.mol
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AG 1478 Property

Melting point:
180 - 183°C
storage temp. 
2-8°C
solubility 
0.1 M HCl: soluble <0.4 mg/mL
form 
Pale yellow solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
658552
Product name
AG 1478
Packaging
5mg
Price
$187
Updated
2024/03/01
Sigma-Aldrich
Product number
658548
Product name
InSolution? AG 1478
Packaging
1mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
T4182
Product name
Tyrphostin AG 1478
Purity
≥98%
Packaging
1mg
Price
$76.2
Updated
2024/03/01
Sigma-Aldrich
Product number
T4182
Product name
Tyrphostin AG 1478
Purity
≥98%
Packaging
5mg
Price
$228
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
KIN0001450
Product name
AG 1478
Purity
95.00%
Packaging
1G
Price
$798
Updated
2021/12/16
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AG 1478 Chemical Properties,Usage,Production

Description

AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines.1,2 AG-1478 reduces pulmonary fibrosis in a rat model.3?Cell permeable.

Uses

Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.

Uses

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.

Uses

Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.

Definition

ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.

General Description

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 >100 μM), the platelet-derived growth factor (PDGF) receptor (IC50 >100 μM), and p210Bcr-Abl (IC50 >50 μM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.

Biochem/physiol Actions

Primary TargetEpidermal growth factor receptor kinase

References

1) Han et al. (1996), Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors; Cancer Res., 56 3859 2) Partik et al. (1999), Inhibition of epidermal-growth-factor-receptor-dependent signaling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro; J. Cancer Res. Clin. Oncol., 125 379 3) Rice et al. (1999), Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats; Am. J. Pathol., 155 213

AG 1478 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 1478 Suppliers

China 88 Germany 1 Japan 2 Switzerland 2 United Kingdom 8 United States 14 Global 115
Alchem Pharmtech,Inc.
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175178-82-2, AG 1478Related Search:

Adapalene ZM 336372 (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Sunitinib Malate RANAKININ NS-398 AG 213 Quinazoline AG 1478 in Solution AG1478HCl,AG-1478,AG 1478 HYDROCHLORIDE Tyrphostin AG 1478 (4-(3-Chloroanilino)-6, 7-dimethoxyquinazoline) AG 1478 EPIDERMAL GROWTH FACT

  • NSC 669364
  • N-[3-CHLOROPHENYL]-6,7-DIMETHOXY-4-QUINAZOLINAMINE
  • N-(3-CHLOROPHENYL)-N-(6,7-DIMETHOXY-4-QUINAZOLINYL)AMINE
  • SU 5271
  • WHI-P 79
  • TYRPHOSTIN AG 1478
  • TYRPHOSTIN AG 1517
  • AG 1478
  • AG 1517
  • 4-(N-3-CHLOROPHENYL)-AMINO-6,7-DIMETHOXYQUINAZOLINE
  • 4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-
  • InSolution AG 1478 - CAS 175178-82-2 - Calbiochem
  • AG 1478 - CAS 175178-82-2 - Calbiochem
  • 4-(3-BROMOPHENYLAMINO)-6,7-BIS(METHOXY)QUINAZOLINE
  • 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE
  • 4-(3-BROMOPHENYLAMINO)-6,7-DIMETHYLQUINAZOLINE
  • 4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE
  • 4-(3-CHLOROANILLINO)-6,7-DIMETHOXYQUINAZOLINE
  • 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE
  • COMPOUND 32
  • TYRPHOSTIN AG 1478, 99+%
  • 4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline
  • 4-Quinazolinamine,N-(3-chlorophenyl)-6,7-dimethoxy-
  • N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
  • Tyrphostin AG 1478, Methanesulfonate Salt
  • InSolution? AG 1478
  • PD-153,035
  • Tyrphostin AG
  • 4-[(3-chlorophenyl)methyl]-6,7-dimethoxyquinazoline
  • AG 1478 USP/EP/BP
  • 175178-82-2
  • 174178-82-2
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Kinase/Phosphatase Biology
  • Epidermal Growth Factor Receptor (EGFR)
  • Receptor Tyrosine Kinase Inhibitors