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Bleomycin hydrochloride

Product Name
Bleomycin hydrochloride
CAS No.
67763-87-5
Chemical Name
Bleomycin hydrochloride
Synonyms
BleomycinHCl;bleomycinchlorhydrate;Suberic Acid Impurity 1;BLEOMYCIN HYDROCHLORIDE;BLEOMYCIN HYDROCHLORIDES;BleomycinA5/Pingyangmycin;BleoMycin A4A5 Hydrochloride;Bleomycin hydrochloride USP/EP/BP;Bleomycin, hydrochloride (9CI, ACI);Bleomycin hydrochlorideQ: What is Bleomycin hydrochloride Q: What is the CAS Number of Bleomycin hydrochloride Q: What is the storage condition of Bleomycin hydrochloride
CBNumber
CB8770570
Molecular Formula
C50H71N16O21S2R.x(HCl)
Formula Weight
0
MOL File
Mol file
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Bleomycin hydrochloride Property

storage temp. 
4°C, protect from light
solubility 
DMSO: 125 mg/mL (86.15 mM)
form 
Solid
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0131163
Product name
Bleomycin(hydrochloride)
Purity
98.81%
Packaging
10mg
Price
$168
Updated
2021/12/16
ChemScene
Product number
CS-0131163
Product name
Bleomycin(hydrochloride)
Purity
98.81%
Packaging
50mg
Price
$672
Updated
2021/12/16
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Bleomycin hydrochloride Chemical Properties,Usage,Production

Originator

Bleomycin Hydrochloride,Nippon Kayaku, Co.,Japan

Manufacturing Process

To a medium having a composition of 6.4 % of millet jelly, 0.5 % of glucose, 3.5 % of soybean powder, 0.75 % of corn steep liquor, 0.3 % of sodium chloride, 0.1 % of potassium secondary phosphate, 0.05 % of zinc sulfate, 0.01 % of copper sulfate, 0.2 % of sodium nitrate and 0.01 % of Toho No. 1 (trade name for a surface active agent composed of polyoxyethylene manufactured by Toho Chemical Industry Co. Ltd., Japan) was added 3-aminopropyl- dimethylsulfonium bromide hydrobromate in a proportion of 0.4 mg/ml to adjust the pH of the medium to 6.5.
Each 100 ml of the thus treated medium was separately charged into a Sakaguchi flask and was then sterilized. Subsequently, Streptomyces verticillus (ATCC No. 15003) was inoculated in the medium and was cultured at 27°C for 8 days with stirring at 130 r.p.m. Thereafter, the culture liquors (4.5 L) were collected and filtered to obtain 3.0 L of a filtrate (potency 38.8 mg/ml, total potency 416.4 mg). This culture filtrate was passed through and adsorbed on a column packed with 200 ml of Amberlite IRC-50 and was washed with water and was eluted with 0.5 N hydrochloric acid. 1.0 L of the eluate was neutralized, was passed through and adsorbed on a column packed with 100 ml of active carbon, was washed and was then eluted by use of a 1:1 (by volume) mixture of acetone - 0.02 N aqueous hydrochloric acid solution, and fractions active to Mycobacterium 607 were collected and concentrated to dryness. The resulting residue was dissolved in 5 ml of an 80 % aqueous methanol solution and was charged into a column packed with 30 ml of neutral alumina, followed by elution with an 80 % aqueous methanol solution. Subsequently, bleomycin-containing fractions were collected and concentrated to dryness to obtain 195 mg of bleomycin hydrochloride (potency 650.7 mcg/mg, total potency 172 mg). The yield from the culture filtrate was 30.5 %.

Therapeutic Function

Antibiotic

Bleomycin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bleomycin hydrochloride manufacturers

Dideu Industries Group Limited
Product
Bleomycin hydrochloride 67763-87-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
Bleomycin hydrochloride 67763-87-5
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

67763-87-5, Bleomycin hydrochlorideRelated Search:


  • bleomycinchlorhydrate
  • BleomycinA5/Pingyangmycin
  • BleomycinHCl
  • BLEOMYCIN HYDROCHLORIDES
  • BleoMycin A4A5 Hydrochloride
  • BLEOMYCIN HYDROCHLORIDE
  • Bleomycin hydrochloride USP/EP/BP
  • Bleomycin hydrochlorideQ: What is Bleomycin hydrochloride Q: What is the CAS Number of Bleomycin hydrochloride Q: What is the storage condition of Bleomycin hydrochloride
  • Bleomycin, hydrochloride (9CI, ACI)
  • Suberic Acid Impurity 1
  • 67763-87-5
  • C50H71N16O21S2RxHCl