Bleomycin hydrochloride
- Product Name
- Bleomycin hydrochloride
- CAS No.
- 67763-87-5
- Chemical Name
- Bleomycin hydrochloride
- Synonyms
- BleomycinHCl;bleomycinchlorhydrate;Suberic Acid Impurity 1;BLEOMYCIN HYDROCHLORIDE;BLEOMYCIN HYDROCHLORIDES;BleomycinA5/Pingyangmycin;BleoMycin A4A5 Hydrochloride;Bleomycin hydrochloride USP/EP/BP;Bleomycin, hydrochloride (9CI, ACI);Bleomycin hydrochlorideQ: What is Bleomycin hydrochloride Q: What is the CAS Number of Bleomycin hydrochloride Q: What is the storage condition of Bleomycin hydrochloride
- CBNumber
- CB8770570
- Molecular Formula
- C50H71N16O21S2R.x(HCl)
- Formula Weight
- 0
- MOL File
- Mol file
Bleomycin hydrochloride Property
- storage temp.
- 4°C, protect from light
- solubility
- DMSO: 125 mg/mL (86.15 mM)
- form
- Solid
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0131163
- Product name
- Bleomycin(hydrochloride)
- Purity
- 98.81%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2021/12/16
- Product number
- CS-0131163
- Product name
- Bleomycin(hydrochloride)
- Purity
- 98.81%
- Packaging
- 50mg
- Price
- $672
- Updated
- 2021/12/16
Bleomycin hydrochloride Chemical Properties,Usage,Production
Originator
Bleomycin Hydrochloride,Nippon Kayaku, Co.,Japan
Manufacturing Process
To a medium having a composition of 6.4 % of millet jelly, 0.5 % of glucose,
3.5 % of soybean powder, 0.75 % of corn steep liquor, 0.3 % of sodium
chloride, 0.1 % of potassium secondary phosphate, 0.05 % of zinc sulfate,
0.01 % of copper sulfate, 0.2 % of sodium nitrate and 0.01 % of Toho No. 1
(trade name for a surface active agent composed of polyoxyethylene
manufactured by Toho Chemical Industry Co. Ltd., Japan) was added 3-aminopropyl-
dimethylsulfonium bromide hydrobromate in a proportion of 0.4 mg/ml
to adjust the pH of the medium to 6.5.
Each 100 ml of the thus treated medium was separately charged into a
Sakaguchi flask and was then sterilized. Subsequently, Streptomyces
verticillus (ATCC No. 15003) was inoculated in the medium and was cultured
at 27°C for 8 days with stirring at 130 r.p.m. Thereafter, the culture liquors
(4.5 L) were collected and filtered to obtain 3.0 L of a filtrate (potency 38.8
mg/ml, total potency 416.4 mg). This culture filtrate was passed through and
adsorbed on a column packed with 200 ml of Amberlite IRC-50 and was
washed with water and was eluted with 0.5 N hydrochloric acid. 1.0 L of the
eluate was neutralized, was passed through and adsorbed on a column packed
with 100 ml of active carbon, was washed and was then eluted by use of a
1:1 (by volume) mixture of acetone - 0.02 N aqueous hydrochloric acid
solution, and fractions active to Mycobacterium 607 were collected and
concentrated to dryness. The resulting residue was dissolved in 5 ml of an 80
% aqueous methanol solution and was charged into a column packed with 30
ml of neutral alumina, followed by elution with an 80 % aqueous methanol
solution. Subsequently, bleomycin-containing fractions were collected and
concentrated to dryness to obtain 195 mg of bleomycin hydrochloride
(potency 650.7 mcg/mg, total potency 172 mg). The yield from the culture
filtrate was 30.5 %.
Therapeutic Function
Antibiotic
Bleomycin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Bleomycin hydrochloride manufacturers
- Product
- Bleomycin hydrochloride 67763-87-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-01
- Product
- Bleomycin hydrochloride 67763-87-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 ton
- Release date
- 2020-04-30