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1-AZETIDINECARBOXYLIC ACID

Product Name
1-AZETIDINECARBOXYLIC ACID
CAS No.
105443-94-5
Chemical Name
1-AZETIDINECARBOXYLIC ACID
Synonyms
1-AZETIDINECARBOXYLIC ACID;(S)-1-Boc-azetidine-2-carboxamide;1-Boc-(S)-azetidine-2-carboxamide;N-(TERT-BUTOXYCARBONY)-L-AZETIDINE-2-CARBAMIDE;N-(TERT-BUTOXYCARBONYL)-L-AZETIDINE-2-CARBAMIDE;(S)-tert-Butyl 2-carbamoylazetidine-1-carboxylate;tert-butyl (S)-2-carbamoylazetidine-1-carboxylate;tert-butyl (2S)-2-carbamoylazetidine-1-carboxylate;tert-butyl (2S)-2-(aminocarbonyl)azetidine-1-carboxylate;(2S)-2-Carbamoylazetidine-1-carboxylic acid tert-butyl ester
CBNumber
CB8783695
Molecular Formula
C9H16N2O3
Formula Weight
200.23
MOL File
105443-94-5.mol
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1-AZETIDINECARBOXYLIC ACID Property

Boiling point:
355.9±31.0 °C(Predicted)
Density 
1.194±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
15.97±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FA14216
Product name
1-Azetidine carboxylic acid
Packaging
1mg
Price
$105
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA14216
Product name
1-Azetidine carboxylic acid
Packaging
5mg
Price
$315
Updated
2021/12/16
Activate Scientific
Product number
AS85716
Product name
(S)-1-Boc-azetidine-2-carboxamide
Purity
95+% ee
Packaging
1g
Price
$335
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA14216
Product name
1-Azetidine carboxylic acid
Packaging
10mg
Price
$472.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA14216
Product name
1-Azetidine carboxylic acid
Packaging
25mg
Price
$714
Updated
2021/12/16
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1-AZETIDINECARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

51077-14-6

105443-94-5

General procedure for the synthesis of tert-butyl (S)-2-carbamoylazetidine-1-carboxylate from 1-Boc-L-acridine-2-carboxylate: Boc-L-2-azetidinecarboxylic acid (compound 8a, 2.91 g, 14.45 mmol) and triethylamine (Et3N, 2.01 mL, 14.45 mmol) were dissolved in tetrahydrofuran (THF, 33 mL) in tetrahydrofuran (THF, 33) and cooled to -10 °C. Under stirring, pre-cooled ethyl chloroformate was slowly added dropwise, and stirring was continued for 20 min by keeping the reaction temperature at -10 °C. Subsequently, 28% ammonia (NH4OH, 3.21 mL) solution was added and the reaction system was gradually warmed up to room temperature. Upon completion of the reaction, the THF solvent was removed by distillation under reduced pressure. The residue was partitioned between ethyl acetate (EtOAc) and water, and the organic phase was separated, dried over anhydrous magnesium sulfate (MgSO4), filtered and the solvent was concentrated under reduced pressure to give compound 9a as a white crystalline solid (2.36 g, 82% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 1.34 (s, 9H), 1.96-1.98 (m, 1H), 2.30-2.39 (m, 1H), 3.75-3.80 (m, 2H), 4.37 (dd, J = 9.1, 5.5 Hz, 1H), 7.11 (s, 1H), 7.34 (s. 1H).

References

[1] Patent: WO2007/23382, 2007, A2. Location in patent: Page/Page column 70
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3037 - 3040
[3] Patent: WO2014/141065, 2014, A1. Location in patent: Page/Page column 50

1-AZETIDINECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-AZETIDINECARBOXYLIC ACID Suppliers

China 27 Europe 1 Germany 1 India 1 United Kingdom 2 United States 8 Global 40
United States Biological
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105443-94-5, 1-AZETIDINECARBOXYLIC ACIDRelated Search:

(R)-N-FMOC-AZETIDINE-2-CARBOXYLIC ACID, 95%, (98% E.E.) 1-Boc-L-azetidine-2-carboxylic acid (R)-2-Azetidinecarboxylic acid (S)-Azetidine-2-carboxylic acid, L-2-Azetidinecarboxylic acid, L-Azetidine-2-carboxylic acid,(2S)-2-Azetidinecarboxylic acid (S)-BENZYL 2-AZETIDINONE-4-CARBOXYLATE POLYOXIN A 1-(Phenylmethyl)-2-azetidinecarboxylic acid methyl ester 1-N-BOC-3-AZETIDINECARBOXYLIC ACID 1-BENZYL-3-AZETIDINECARBOXYLIC ACID 1-Fmoc-3-Azetidinecarboxylic acid (3R-cis)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]-1-azetidinecarboxylic Acid 1,1-Dimethylethyl Ester 3-Bromo-1-azetidinecarboxylic acid benzyl ester 3-AZETIDINECARBOXYLIC ACID, 1-(DIPHENYLMETHYL)-, METHYL ESTER 1-Azetidinecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester 1-BENZHYDRYL-3-AZETIDINECARBOXYLIC ACID (+/-)-TRANS-AZETIDINE-2,4-DICARBOXYLIC ACID (S)-(-)-4-OXO-2-AZETIDINECARBOXYLIC ACID BENZYL N-DIPHENYLMETHYL-2-AZETIDINECARBOXYLATE

  • 1-AZETIDINECARBOXYLIC ACID
  • (2S)-2-Carbamoylazetidine-1-carboxylic acid tert-butyl ester
  • N-(TERT-BUTOXYCARBONYL)-L-AZETIDINE-2-CARBAMIDE
  • N-(TERT-BUTOXYCARBONY)-L-AZETIDINE-2-CARBAMIDE
  • (S)-tert-Butyl 2-carbamoylazetidine-1-carboxylate
  • tert-butyl (2S)-2-(aminocarbonyl)azetidine-1-carboxylate
  • 1-Boc-(S)-azetidine-2-carboxamide
  • tert-butyl (2S)-2-carbamoylazetidine-1-carboxylate
  • 1-Azetidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2S)-
  • (S)-1-Boc-azetidine-2-carboxamide
  • tert-butyl (S)-2-carbamoylazetidine-1-carboxylate
  • 105443-94-5