ChemicalBook > CAS DataBase List > Angiotensin II, 5-L-isoleucine-8-glycine-
Angiotensin II, 5-L-isoleucine-8-glycine-
- Product Name
- Angiotensin II, 5-L-isoleucine-8-glycine-
- CAS No.
- 40678-47-5
- Chemical Name
- Angiotensin II, 5-L-isoleucine-8-glycine-
- Synonyms
- TRV120056;Angiotensin II, 5-L-isoleucine-8-glycine-
- CBNumber
- CB88383578
- Molecular Formula
- C43H65N13O12
- Formula Weight
- 956.07
- MOL File
- 40678-47-5.mol
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Angiotensin II, 5-L-isoleucine-8-glycine- Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 3.67±0.10(Predicted)
- color
- White to off-white
- Sequence
- Asp-Arg-Val-Tyr-Ile-His-Pro-Gly
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Angiotensin II, 5-L-isoleucine-8-glycine- Chemical Properties,Usage,Production
Uses
TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].
References
[1] Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77. DOI:10.1124/mol.111.072801
[2] Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24. DOI:10.1074/jbc.M114.548131
Angiotensin II, 5-L-isoleucine-8-glycine- Preparation Products And Raw materials
Raw materials
Preparation Products
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Angiotensin II, 5-L-isoleucine-8-glycine- Suppliers
- Tel
- --
- Fax
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- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
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