Pyridoxine hydrochloride

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Pyridoxine hydrochloride

Nutrition supplements

Product Name: Pyridoxine hydrochloride
CAS No.: 58-56-0
Chemical Name: Pyridoxine hydrochloride
Synonyms: Pyridoxine hydrochloride (Vitamin B6);campoviton6;5-Hydroxy-6-methyl-3,4-pyridinedimethanol;pyridox;paxadon;becilan;benadon;hexobion;hexermin;aderoxin
CBNumber: CB8853882
Molecular Formula: C8H12ClNO3
Formula Weight: 205.64
MOL File: 58-56-0.mol

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Pyridoxine hydrochloride Property

Melting point:: 214-215 °C(lit.)
Density: 1.2784 (rough estimate)
vapor density: 7.1 (vs air)
refractive index: 1.5800 (estimate)
Flash point:: 9℃
storage temp.: room temp
solubility: H₂O: 0.1 g/mL at 20 °C, clear, colorless
form: Crystalline Powder
color: White to almost white
PH Range: 3.2
Water Solubility: 0.1 g/mL (20 ºC)
Sensitive: Light Sensitive
Merck: 14,7982
BRN: 3632435
BCS Class: 1
Stability:: Stable. Protect from air and light.
LogP: -1.098 (est)
CAS DataBase Reference: 58-56-0(CAS DataBase Reference)
EPA Substance Registry System: 5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride (58-56-0)

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Safety

Hazard Codes: Xi,T,F
Risk Statements: 36/37/38-39/23/24/25-23/24/25-11
Safety Statements: 26-37/39-45-36/37-16-7-24/25
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 2
RTECS: UV1350000
F: 8-10
TSCA: Yes
HS Code: 29362500
Hazardous Substances Data: 58-56-0(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 80823
Product name: Pyridoxine hydrochloride
Purity: certified reference material, TraceCERT
Packaging: 50mg
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: 47862
Product name: Pyridoxine Hydrochloride (B6)
Purity: analytical standard
Packaging: 1000mg
Price: $23.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1587001
Product name: Pyridoxine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $447
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP458
Product name: Pyridoxine hydrochloride
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $221
Updated: 2023/06/20

TCI Chemical

Product number: P0561
Product name: Pyridoxine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $44
Updated: 2024/03/01

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Pyridoxine hydrochloride Chemical Properties,Usage,Production

Nutrition supplements

Pyridoxine hydrochloride(58-56-0) is the hydrochloride salt of Vitamin B6. Vitamin B6 (B6) is a water-soluble vitamin, which can be found in various foods such as fish, poultry, whole grains, legumes, banana, nuts, and sesame.Vitamin B6 has an important role in the metabolism of amino acids as a coenzyme, pyridoxal 5'-phosphate.

B6 may exert an anticolon tumor effect by the protection of the colon epithelium from damage in rats treated with 1,2-dimethylhidrazine (DMH) and to decreased lithocholic acid, a colon carcinogen. Vitamin B6 may prevent such diseases by lowering inflammation.

Chemical Properties

White or almost white, crystalline powder.

Uses

Pyridoxine Hydrochloride is an acid form of vitamin b6, a water- soluble vitamin. it is soluble in water, and slightly soluble in alco- hol. it is slowly affected by sunlight and is reasonably stable in air. it has a ph of 2.3–3.5. it is also termed vitamin b6 hydrochloride. see pyridoxine.

Application

Pyridoxine hydrochloride has been used:
As a vitamin component in a chemically defined diet with balanced metal content for metal depletion studies;
As a component of chemically defined medium (CDM) to culture Staphylococcus aureus WSPPA;
As analytical reference standards for the determination of analytes in pharmaceutical preparations by chromatography and spectrophotometric techniques;
As a vitamin to study the impact of protein expression and post-translational modifications specifically charge heterogeneity;
As a medicine, it is used to prevent or treat certain neurological disorders (peripheral neuropathy) caused by certain drugs (e.g. isoniazid). It is also used in the treatment of certain hereditary disorders (e.g. flavoururic aciduria, hyperoxaluria, homocystinuria).

Definition

ChEBI: Pyridoxine hydrochloride is the hydrochloride salt of pyridoxine. It is a hydrochloride and a vitamin B6. It contains a pyridoxine.

brand name

Hexa-Betalin (Lilly).

General Description

Vitamin B6 has six forms namely, pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Pyridoxine hydrochloride primarily treats vitamin B6 deficiency and helps alleviate nausea and vomiting during pregnancy. It exists in various forms, including pyridoxine, pyridoxal, and pyridoxamine, which convert into the active coenzyme pyridoxal 5-phosphate (PLP or P5P) in the body.

Biochem/physiol Actions

Vitamin B6 is an essential coenzyme for amino acid, carbohydrate and lipid metabolism. Pyridoxine serves as a primary source in multivitamins. Pyridoxine deficiency is associated with peripheral neuropathy.

Clinical Use

Vitamin B6

Side effects

Common side effects of Pyridoxine hydrochloride include: headache, nausea, drowsiness, mild numbness or tingling. Serious allergic reactions are rare and include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing, decreased sensation of touch, temperature, and vibration; loss of balance or coordination. If serious side effects occur please seek medical attention.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human reproductive effects by ingestion and intramuscular routes: postpartum changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl.

Metabolism

Pyridoxine hydrochloride is metabolised to its active form pyridoxamine phosphate. It is stored mainly in the liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites which are excreted in the urine.

Purification Methods

Purify the vitamin by recrystallisation from EtOH/Me2CO, n-BuOH or MeOH/Et2O. Its solubility in H2O is 22%, and in EtOH it is 1.1%. It is insoluble in Et2O and CHCl3. Acidic aqueous solutions are stable at 120o/30minute. The free base has m 159-160o after recrystallisation from Me2CO and sublimation at 140-145o/0.0001mm. It has UV max at 290nm ( 84,000), 253 and 325nm ( 3,700 and 7,100) in 0.1N aqueous HCl. [Khua & Wendt Chem Ber 71 780 1938, 72 311 1939, Harris & Folkers J Am Chem Soc 61 1242 1939, Harris et al. J Am Chem Soc 62 3198 1940, Beilstein 21/5 V 492.]

Pyridoxine hydrochloride Preparation Products And Raw materials

Raw materials

L-Alanine 5-Ethoxy-4-methyloxazole Chloroform Isopropyl acetate

Preparation Products

Pyridoxal hydrochloride 4-Pyridoxic acid Pyridoxamine dihydrochloride

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View Lastest Price from Pyridoxine hydrochloride manufacturers

Sinoway Industrial co., ltd.

Product: Vitamin B6 58-56-0
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2024-06-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pyridoxine hydrochloride 58-56-0
Price: US $0.00/Kg/Drum
Min. Order: 25KG
Purity: 98%-102%; USP/BP
Supply Ability: 1000 KG
Release date: 2021-05-31

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Pyridoxine hydrochloride 58-56-0
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-28

58-56-0, Pyridoxine hydrochlorideRelated Search:

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