2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE
- Product Name
- 2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE
- CAS No.
- 38427-94-0
- Chemical Name
- 2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE
- Synonyms
- BOC-2-AMinopyridine;N-Boc-2-pyridineamine;2-(BOC-AMINO)-PYRIDINE;2-(N-BOC-AMINO)PYRIDINE;Linagliptin Impurity 77;2-(Boc-amino)pyridine, 95%,;t-Butyl pyridin-2-ylcarbamate;tert-Butyl 2-pyridinecarbamate;2-Aminopyridine, 2-BOC protected;TERT-BUTYL PYRIDIN-2-YLCARBAMATE
- CBNumber
- CB9128978
- Molecular Formula
- C10H14N2O2
- Formula Weight
- 194.23
- MOL File
- 38427-94-0.mol
2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE Property
- Melting point:
- 95-97 ºC
- Boiling point:
- 253 ºC
- Density
- 1.131
- Flash point:
- 107 ºC
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 12.56±0.70(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 38427-94-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-43-36/37/38
- Safety Statements
- 36/37-36-26
- WGK Germany
- 3
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 734705
- Product name
- 2-(Boc-amino)pyridine
- Purity
- 96%
- Packaging
- 1g
- Price
- $105
- Updated
- 2023/06/20
- Product number
- B621185
- Product name
- 2-(Boc-amino)pyridine
- Packaging
- 25g
- Price
- $1095
- Updated
- 2021/12/16
- Product number
- CHM0007316
- Product name
- 2-(BOC-AMINO)PYRIDINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1300.53
- Updated
- 2021/12/16
- Product number
- FB149560
- Product name
- 2-(tert-Butoxycarbonylamino)pyridine
- Packaging
- 2g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- FB149560
- Product name
- 2-(tert-Butoxycarbonylamino)pyridine
- Packaging
- 5G
- Price
- $498
- Updated
- 2021/12/16
2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE Chemical Properties,Usage,Production
Uses
2-(Boc-amino)pyridine is a protected derivative of the amino acid Pyridine, a heterocyclic compound that is commonly found in biological specimens (such as human red blood cells), and is used as a starting reagent and intermediate in the chemical and pharmaceutical industries.
Synthesis
504-29-0
24424-99-5
38427-94-0
General method: 2-aminopyridine (1 mmol) and di-tert-butyl dicarbonate (1.1 mmol) were placed in a microwave reaction vial. The reaction was carried out using an LG microwave oven MG 555f set at 100°C and 300W. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, ice water was added to the reaction mixture to precipitate tert-butyl pyridin-2-ylcarbamate. The solid product was collected by filtration and washed with excess cold water. The resulting product is pure enough for routine applications. For further characterization, it can be purified by column chromatography using neutral alumina as adsorbent with a solvent ratio of hexane: ethyl acetate (7.5:2.5).
References
[1] Chemistry Letters, 2010, vol. 39, # 11, p. 1127 - 1129
[2] Journal of Organic Chemistry, 2002, vol. 67, # 14, p. 4965 - 4967
[3] RSC Advances, 2014, vol. 4, # 47, p. 24544 - 24550
[4] New Journal of Chemistry, 2018, vol. 42, # 12, p. 10142 - 10147
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE manufacturers
- Product
- 2-(Boc-amino)pyridine 38427-94-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-(Boc-amino)pyridine 38427-94-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE 38427-94-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19