ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-methoxyaniline

2,4-Dichloro-5-methoxyaniline

Product Name
2,4-Dichloro-5-methoxyaniline
CAS No.
98446-49-2
Chemical Name
2,4-Dichloro-5-methoxyaniline
Synonyms
5-Amino-2,4-d;Bosutinib Impurity 12;Bosutinib Impurity 25;4,6-Dichloro-m-anisidine;Bosutinib Impurity 12 CRS;5-AMINO-4,6-DICHLOROANISOLE;5-Amino-2,4-Dichloroanisole;2,4-DICHLORO-5-METHOXYANILINE;2,4-Dichloro-5-methhoxyaniline;5-Amino-2,4-dichloroanisole >
CBNumber
CB9130874
Molecular Formula
C7H7Cl2NO
Formula Weight
192.04
MOL File
98446-49-2.mol
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2,4-Dichloro-5-methoxyaniline Property

Melting point:
51 °C
Boiling point:
290.1±35.0 °C(Predicted)
Density 
1.375±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
1.59±0.10(Predicted)
color 
Pale Brown
InChIKey
AJROJTARXSATEB-UHFFFAOYSA-N
CAS DataBase Reference
98446-49-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
RIDADR 
UN2810
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
2922290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2085
Product name
5-Amino-2,4-dichloroanisole
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$75
Updated
2025/07/31
TCI Chemical
Product number
A2085
Product name
5-Amino-2,4-dichloroanisole
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$242
Updated
2025/07/31
TRC
Product number
D434815
Product name
2,4-Dichloro-5-methoxyaniline
Packaging
1g
Price
$70
Updated
2021/12/16
TRC
Product number
D434815
Product name
2,4-Dichloro-5-methoxyaniline
Packaging
500mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR4527
Product name
2,4-Dichloro-5-methoxyaniline
Packaging
100g
Price
$319
Updated
2021/12/16
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2,4-Dichloro-5-methoxyaniline Chemical Properties,Usage,Production

Uses

2,4-Dichloro-5-methoxyaniline is mainly used to prepare bosutinib intermediate 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(3-chloropropoxy)-3-quinolinecarbonitrile

Synthesis

2,4-Dichloro-5-methoxyaniline is mainly used to prepare bosutinib intermediate 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(3-chloropropoxy)-3-quinolinecarbonitrile

Synthesis

65182-98-1

98446-49-2

General procedure for the synthesis of 2,4-dichloro-5-methoxyaniline from N-(2,4-dichloro-5-methoxyphenyl)acetamide: N-(2,4-dichloro-5-methoxyphenyl)acetamide (100.7 g, 0.43 mol) was suspended in a mixture of ethanol (500 g), water (500 g), and concentrated hydrochloric acid (300 g, 3 mol), stirred and heated to 70 °C and the reaction lasted for 12 h to obtain a brown solution. After completion of the reaction, ethanol (about 200 g) was evaporated under reduced pressure and the remaining mixture was stirred and cooled to room temperature. After standing for 2 h, the precipitated solid was collected by filtration, washed with water (2 x 200 g) and dried under vacuum at 35 °C to afford 2,4-dichloro-5-methoxyaniline (69.4 g, 84% yield) as a light tan solid with a melting point of 49.5-51.1 °C (literature value 50.5-51.5 °C). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (EI): 1H NMR δ= 3.76 (s, 3H), 5.13 (br s, 2H), 6.58 (s, 1H), 7.23 (s, 1H); mass spectrum (EI) m/z (relative abundance) = 191 (100).

References

[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3133 - 3138
[2] Journal of the American Chemical Society, 1919, vol. 41, p. 460

2,4-Dichloro-5-methoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-5-methoxyaniline Suppliers

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View Lastest Price from 2,4-Dichloro-5-methoxyaniline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2,4-Dichloro-5-methoxyaniline 98446-49-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-24
Jinan Finer Chemical Co., Ltd
Product
2,4-Dichloro-5-methoxyaniline 98446-49-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2019-03-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,4-Dichloro-5-methoxyaniline 98446-49-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

98446-49-2, 2,4-Dichloro-5-methoxyanilineRelated Search:

p-Anisaldehyde Anisole 3-Ethoxyaniline 2,4-Dimethoxyaniline (Trifluoromethoxy)benzene 4-(Trifluoromethoxy)aniline 4-Aminoveratrole p-Anisidine 4-Methoxybenzoic acid 4-Methoxyphenol 4-Methoxybenzylchloride 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Bosutinib Impurity Bosutinib Impurity 15 Bosutinib Impurity 6 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE Bosutinib Impurity 4 1,3-diisopropylurea

  • 2,4-DICHLORO-5-METHOXYANILINE
  • 2,4-Dichloro-5-methoxybenzenamine
  • 4,6-Dichloro-m-anisidine
  • 2,4-dichloro-5-methoxyphenylamine
  • 5-AMINO-4,6-DICHLOROANISOLE
  • BENZENAMINE,2,4-DICHLORO-5-METHOXY-
  • 5-Amino-2,4-dichloroanisole, 4,5-Dichloro-m-anisidine
  • 5-Amino-2,4-dichloroanisole, 4,6-Dichloro-m-anisidine
  • 5-AMino-2,4-dichloroanisole[2,4-Dichloro-5-Methoxyaniline]
  • 5-Amino-2,4-dichloroanisole, 4,5-Dichl
  • 5-Amino-2,4-d
  • Bosutinib Impurity 12
  • 2,4-Dichloro-5-methoxyaniline 4,6-Dichloro-m-anisidine
  • Bosutinib Impurity 25
  • 5-Amino-2,4-dichloroanisole &gt
  • 2,4-Dichloro-5-methoxyaniline (Bosutinib Impurity)
  • 5-Amino-2,4-Dichloroanisole
  • 2,4-Dichloro-5-methhoxyaniline
  • Bosutinib Impurity 12 CRS
  • 98446-49-2
  • 9844-49-2
  • Heterocyclic Compounds
  • Anilines, Amides & Amines
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Chlorine Compounds