2,4-Dichloro-5-methoxyaniline

Product Name: 2,4-Dichloro-5-methoxyaniline
CAS No.: 98446-49-2
Chemical Name: 2,4-Dichloro-5-methoxyaniline
Synonyms: 5-Amino-2,4-d;Bosutinib Impurity 12;Bosutinib Impurity 25;4,6-Dichloro-m-anisidine;Bosutinib Impurity 12 CRS;5-AMINO-4,6-DICHLOROANISOLE;5-Amino-2,4-Dichloroanisole;2,4-DICHLORO-5-METHOXYANILINE;2,4-Dichloro-5-methhoxyaniline;5-Amino-2,4-dichloroanisole >
CBNumber: CB9130874
Molecular Formula: C7H7Cl2NO
Formula Weight: 192.04
MOL File: 98446-49-2.mol

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2,4-Dichloro-5-methoxyaniline Property

Melting point:: 51 °C
Boiling point:: 290.1±35.0 °C(Predicted)
Density: 1.375±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 1.59±0.10(Predicted)
color: Pale Brown
InChIKey: AJROJTARXSATEB-UHFFFAOYSA-N
CAS DataBase Reference: 98446-49-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: UN2810
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2085
Product name: 5-Amino-2,4-dichloroanisole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: A2085
Product name: 5-Amino-2,4-dichloroanisole
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $242
Updated: 2025/07/31

TRC

Product number: D434815
Product name: 2,4-Dichloro-5-methoxyaniline
Packaging: 1g
Price: $70
Updated: 2021/12/16

TRC

Product number: D434815
Product name: 2,4-Dichloro-5-methoxyaniline
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR4527
Product name: 2,4-Dichloro-5-methoxyaniline
Packaging: 100g
Price: $319
Updated: 2021/12/16

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2,4-Dichloro-5-methoxyaniline Chemical Properties,Usage,Production

Uses

2,4-Dichloro-5-methoxyaniline is mainly used to prepare bosutinib intermediate 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(3-chloropropoxy)-3-quinolinecarbonitrile

Synthesis

2,4-Dichloro-5-methoxyaniline is mainly used to prepare bosutinib intermediate 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(3-chloropropoxy)-3-quinolinecarbonitrile

Synthesis

65182-98-1

98446-49-2

General procedure for the synthesis of 2,4-dichloro-5-methoxyaniline from N-(2,4-dichloro-5-methoxyphenyl)acetamide: N-(2,4-dichloro-5-methoxyphenyl)acetamide (100.7 g, 0.43 mol) was suspended in a mixture of ethanol (500 g), water (500 g), and concentrated hydrochloric acid (300 g, 3 mol), stirred and heated to 70 °C and the reaction lasted for 12 h to obtain a brown solution. After completion of the reaction, ethanol (about 200 g) was evaporated under reduced pressure and the remaining mixture was stirred and cooled to room temperature. After standing for 2 h, the precipitated solid was collected by filtration, washed with water (2 x 200 g) and dried under vacuum at 35 °C to afford 2,4-dichloro-5-methoxyaniline (69.4 g, 84% yield) as a light tan solid with a melting point of 49.5-51.1 °C (literature value 50.5-51.5 °C). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (EI): 1H NMR δ= 3.76 (s, 3H), 5.13 (br s, 2H), 6.58 (s, 1H), 7.23 (s, 1H); mass spectrum (EI) m/z (relative abundance) = 191 (100).

References

[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3133 - 3138
[2] Journal of the American Chemical Society, 1919, vol. 41, p. 460

2,4-Dichloro-5-methoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-5-methoxyaniline Suppliers

Americas 1 China 244 Czech Republic 1 Europe 2 Germany 3 India 10 Japan 3 The Netherlands 1 United Kingdom 6 United States 22 Global 293

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INTATRADE GmbH

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from 2,4-Dichloro-5-methoxyaniline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-Dichloro-5-methoxyaniline 98446-49-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-04-24

Jinan Finer Chemical Co., Ltd

Product: 2,4-Dichloro-5-methoxyaniline 98446-49-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2019-03-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,4-Dichloro-5-methoxyaniline 98446-49-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

98446-49-2, 2,4-Dichloro-5-methoxyanilineRelated Search:

p-Anisaldehyde Anisole 3-Ethoxyaniline 2,4-Dimethoxyaniline (Trifluoromethoxy)benzene 4-(Trifluoromethoxy)aniline 4-Aminoveratrole p-Anisidine 4-Methoxybenzoic acid 4-Methoxyphenol 4-Methoxybenzylchloride 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Bosutinib Impurity Bosutinib Impurity 15 Bosutinib Impurity 6 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE Bosutinib Impurity 4 1,3-diisopropylurea

2,4-DICHLORO-5-METHOXYANILINE

2,4-Dichloro-5-methoxybenzenamine

4,6-Dichloro-m-anisidine

2,4-dichloro-5-methoxyphenylamine

5-AMINO-4,6-DICHLOROANISOLE

BENZENAMINE,2,4-DICHLORO-5-METHOXY-

5-Amino-2,4-dichloroanisole, 4,5-Dichloro-m-anisidine

5-Amino-2,4-dichloroanisole, 4,6-Dichloro-m-anisidine

5-AMino-2,4-dichloroanisole[2,4-Dichloro-5-Methoxyaniline]

5-Amino-2,4-dichloroanisole, 4,5-Dichl

5-Amino-2,4-d

Bosutinib Impurity 12

2,4-Dichloro-5-methoxyaniline 4,6-Dichloro-m-anisidine

Bosutinib Impurity 25

5-Amino-2,4-dichloroanisole &gt

2,4-Dichloro-5-methoxyaniline (Bosutinib Impurity)

5-Amino-2,4-Dichloroanisole

2,4-Dichloro-5-methhoxyaniline

Bosutinib Impurity 12 CRS

98446-49-2

9844-49-2

Heterocyclic Compounds

Anilines, Amides & Amines

Anisoles, Alkyloxy Compounds & Phenylacetates

Chlorine Compounds